Phenotypes Associated with This Genotype

Genotype
MGI:8399729

• Allelic Composition: Cldn1^tm1Sats/Cldn1^tm1Sats
• Genetic Background: B6JSlc.Cg-Cldn1^tm1Sats

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:234330 )

N • survival rate at 8 weeks is over 80%, similar to that seen in wild-type mice

integument

dermatitis ( J:234330 )

• a substantial number of Gr-1+ neutrophils are seen in the skin at 2 weeks of age but not at 8 weeks of age

• F4/80+ macrophages are detected in the epidermis at 2 weeks, but not at 8 weeks of age

• however, similar levels of inflammatory markers are seen in newborn skin as in wild-type

increased susceptibility to chemically induced skin inflammation ( J:234330 )

• mice exhibit increased skin thickness and show more severe edema and inflammation in response to hapten-induced contact hypersensitivity

dry hair ( J:234330 )

• mice show age-dependent changes in skin appearance, showing wrinkled skin at 1 week of age, abnormal dry hair at 2 weeks, and are nearly normal at 8 weeks

increased hair follicle number ( J:234330 )

abnormal epidermis stratum corneum morphology ( J:234330 )

• newborns show abnormal differentiation of the stratum corneum

hyperkeratosis ( J:234330 )

• orthohyperkeratotic stratum corneum

acanthosis ( J:234330 )

thick epidermis ( J:234330 )

• epidermis is thickened at 2 weeks of age, but not at 8 weeks of age

wrinkled skin ( J:234330 )

• mice show age-dependent changes in skin appearance, showing wrinkled skin at 1 week of age, abnormal dry hair at 2 weeks, and are nearly normal at 8 weeks

abnormal skin development ( J:234330 )

• newborns show abnormal differentiation of the stratum corneum

immune system

dermatitis ( J:234330 )

• a substantial number of Gr-1+ neutrophils are seen in the skin at 2 weeks of age but not at 8 weeks of age

• F4/80+ macrophages are detected in the epidermis at 2 weeks, but not at 8 weeks of age

• however, similar levels of inflammatory markers are seen in newborn skin as in wild-type

increased susceptibility to chemically induced skin inflammation ( J:234330 )

• mice exhibit increased skin thickness and show more severe edema and inflammation in response to hapten-induced contact hypersensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:234330