Cldn1^tm1Sats
Targeted Allele Detail

Summary

• Symbol: Cldn1^tm1Sats
• Name: claudin 1; targeted mutation 1, Sachiko Tsukita
• MGI ID: MGI:8399712
• Synonyms: Cldn1^delta, flox-neo, KD, neo-flox
• Gene: Cldn1 Location: Chr16:26175395-26190589 bp, - strand Genetic Position: Chr16, 18.0 cM
• Alliance: Cldn1^tm1Sats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234330
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details:

  A loxP site and a FRT-flanked neomycin cassette were inserted upstream of exon 1 and a second loxP site was inserted downstream of exon 1. RT-PCR and immunoblotting show a reduction in mRNA expression and protein levels, respectively. (J:234330)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn1 Mutation: 31 strains or lines available

References

• Original: J:234330 Tokumasu R, et al., Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4061-8
• All: 1 reference(s)