Cldn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cldn1
claudin 1
MGI:1276109

26 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cldn1^tm1.2Sats/Cldn1^tm1.2Sats B6JSlc.Cg-Cldn1^tm1.2Sats	abnormal epidermis stratum corneum morphology	J:234330
	abnormal skin development	J:234330
	impaired skin barrier function	J:234330
	neonatal lethality, complete penetrance	J:234330
Cldn1^{tm1b(NCOM)Mfgc}/Cldn1^{tm1b(NCOM)Mfgc} C57BL/6N-Cldn1^{tm1b(NCOM)Mfgc}/Tcp	preweaning lethality, complete penetrance	J:211773
Cldn1^tm1Sats/Cldn1^tm1.2Sats B6JSlc.Cg-Cldn1^tm1Sats/Cldn1^tm1.2Sats	abnormal epidermis stratum basale morphology	J:234330
	abnormal epidermis stratum corneum morphology	J:234330
	abnormal skin development	J:234330
	abnormal skin morphology	J:234330
	acanthosis	J:234330
	decreased IgE level	J:234330
	decreased survivor rate	J:234330
	dermatitis	J:234330
	dry hair	J:234330
	epidermal desquamation	J:234330
	hyperkeratosis	J:234330
	impaired skin barrier function	J:234330
	increased cell proliferation	J:234330
	increased hair follicle number	J:234330
	neonatal lethality, incomplete penetrance	J:234330
	orthokeratosis	J:234330
	postnatal lethality, incomplete penetrance	J:234330
	thick epidermis	J:234330
	wrinkled skin	J:234330
Cldn1^tm1Sats/Cldn1^tm1Sats B6JSlc.Cg-Cldn1^tm1Sats	abnormal epidermis stratum corneum morphology	J:234330
	abnormal skin development	J:234330
	acanthosis	J:234330
	dermatitis	J:234330
	dry hair	J:234330
	hyperkeratosis	J:234330
	increased hair follicle number	J:234330
	increased susceptibility to chemically induced skin inflammation	J:234330
	normal mortality/aging	J:234330
	thick epidermis	J:234330
	wrinkled skin	J:234330
Cldn1^tm1Sts/Cldn1^tm1Sts involves: 129S4/SvJae * C57BL/6	abnormal hair growth	J:75447
	dehydration	J:75447
	hyperkeratosis	J:75447
	impaired skin barrier function	J:75447
	neonatal lethality, complete penetrance	J:75447
	thick epidermis	J:75447
	weight loss	J:75447
	wrinkled skin	J:75447

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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