Analysis Tools
mortality/aging
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• survival rate at 8 weeks of age is 4%
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• half of mice die within 1 day of birth
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• mice usually do not survive beyond weaning
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integument
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• newborn epidermis shows increased paracellular permeability through tight junctions
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dermatitis
(
J:234330
)
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• severe skin defects in infancy that improve with age, similar to infantile eczema in human atopic dermatitis patients
• a substantial number of Gr-1+ neutrophils are seen in the skin at 2 weeks of age but not at 8 weeks of age
• F4/80+ macrophages are detected in the epidermis at 2 and 8 weeks of age
• skin shows increased expression of proinflammatory marker IL-beta by 1 week of age, which is later decreased in adults by 8 weeks of age
• neutrophil chemoattractant KC and macrophage chemoattractant MCP-1 expression in the skin is increased at 1 week of age but these levels decrease by 8 weeks of age
• skin of 2-week-old mice shows higher levels of IL-12p35, IL-12p40, IFN-gamma, and IL-10, but not IL-4
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• mice show age-dependent changes in skin appearance, with severe desquamation and wrinkled skin at 2 weeks, which improves but is still apparent at 8 weeks such that they still exhibit a different severity of skin lesion from wild-type by dermatitis score
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• 2-week-old mice show ectopic proliferation in the subapical basal layer
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• newborns show abnormal differentiation of the stratum corneum
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• orthohyperkeratotic stratum corneum
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acanthosis
(
J:234330
)
|
• mice show desquamination at 2 weeks and severe desquamation at 8 weeks of age
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• epidermis is thickened at 2 weeks of age but not at 8 weeks of age
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• mice show wrinkled skin at 1 and 2 weeks of age
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• abnormal skin differentiation in infant stages, especially in the proliferation layers, with skin mimic the changes seen in atopic dermatitis
• newborns show abnormal differentiation of the stratum corneum
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immune system
|
• mice exhibit lower IgE serum levels
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dermatitis
(
J:234330
)
|
• severe skin defects in infancy that improve with age, similar to infantile eczema in human atopic dermatitis patients
• a substantial number of Gr-1+ neutrophils are seen in the skin at 2 weeks of age but not at 8 weeks of age
• F4/80+ macrophages are detected in the epidermis at 2 and 8 weeks of age
• skin shows increased expression of proinflammatory marker IL-beta by 1 week of age, which is later decreased in adults by 8 weeks of age
• neutrophil chemoattractant KC and macrophage chemoattractant MCP-1 expression in the skin is increased at 1 week of age but these levels decrease by 8 weeks of age
• skin of 2-week-old mice shows higher levels of IL-12p35, IL-12p40, IFN-gamma, and IL-10, but not IL-4
|
homeostasis/metabolism
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• newborn epidermis shows increased paracellular permeability through tight junctions
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hematopoietic system
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• mice exhibit lower IgE serum levels
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cellular
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• 2-week-old mice show ectopic proliferation in the subapical basal layer
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| atopic dermatitis | DOID:3310 |
OMIM:603165 OMIM:PS603165 |
J:234330 | |
