Gene Expression Literature Summary

• Symbol: Cldn1
• Name: claudin 1
• ID: MGI:1276109

58 matching records from 58 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E4.5	E5	E8	E8.5	E9	E10	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)	1	1	1	2	1		1	1	3		2	1	5	5	3	5	5		2	12
In situ RNA (section)								1	1		1		3	2		1				3
Western blot									1	1	1		1		1	2	3	1	2	8
RT-PCR						1	1	2	3				3	2	5		3			13

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cldn1  claudin 1
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:327336 Bertol JW, Johnston S, Ahmed R, Xie VK, Hubka KM, Cruz L, Nitschke L, Stetsiv M, Goering JP, Nistor P, Lowell S, Hoskens H, Claes P, Weinberg SM, Saadi I, Farach-Carson MC, Fakhouri WD, TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068
1	J:190582 Bondow BJ, Faber ML, Wojta KJ, Walker EM, Battle MA, E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012 Nov 1;371(1):1-12
1	J:338915 Cazorla-Vazquez S, Kosters P, Bertz S, Pfister F, Daniel C, Dedden M, Zundler S, Jobst-Schwan T, Amann K, Engel FB, Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney. Cells. 2023 Aug 2;12(15)
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*	J:228856 DiTommaso T, Cottle DL, Pearson HB, Schluter H, Kaur P, Humbert PO, Smyth IM, Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet. 2014 Oct;10(10):e1004706
1*	J:173636 Dravis C, Henkemeyer M, Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues. Dev Biol. 2011 Jul 1;355(1):138-51
2	J:198889 El-Hashash AH, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D, Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 1;125(Pt 17):4036-48
1	J:183190 Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser S, Michels C, Gunschmann C, Sandhoff K, Niessen CM, Niemann C, TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function. J Invest Dermatol. 2012 Feb;132(2):337-45
2	J:306457 Fiorentino A, Christophorou A, Massa F, Garbay S, Chiral M, Ramsing M, Rasmussen M, Gubler MC, Bessieres B, Heidet L, Fischer E, Pontoglio M, Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease. Cell Rep. 2020 Oct 27;33(4):108304
1	J:166833 Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI, The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell. 2010 Nov 16;19(5):727-39
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5*	J:93085 Hashizume A, Ueno T, Furuse M, Tsukita S, Nakanishi Y, Hieda Y, Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland. Dev Dyn. 2004 Oct;231(2):425-31
1	J:194051 Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyrylainen R, Shan J, Vainio S, Umbhauer M, Cereghini S, HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85
2	J:78912 Hellstrom M, Gerhardt H, Kalen M, Li X, Eriksson U, Wolburg H, Betsholtz C, Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001 Apr 30;153(3):543-53
2	J:307816 Heymans C, Delcorte O, Spourquet C, Villacorte-Tabelin M, Dupasquier S, Achouri Y, Mahibullah S, Lemoine P, Balda MS, Matter K, Pierreux CE, Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function. Sci Rep. 2021 Jul 15;11(1):14519
1	J:313345 Higashi AY, Higashi T, Furuse K, Ozeki K, Furuse M, Chiba H, Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. Sci Rep. 2021 Nov 4;11(1):21642
1	J:250152 Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z, Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12;5:12982
1*	J:97304 Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD, Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005 Mar 25;120(6):843-56
1	J:101729 Indra AK, Dupe V, Bornert JM, Messaddeq N, Yaniv M, Mark M, Chambon P, Metzger D, Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation. Development. 2005 Oct;132(20):4533-44
1	J:294228 Kalailingam P, Wang KQ, Toh XR, Nguyen TQ, Chandrakanthan M, Hasan Z, Habib C, Schif A, Radio FC, Dallapiccola B, Weiss K, Nguyen LN, Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. J Clin Invest. 2020 Aug 3;130(8):4081-4093
5	J:180837 Kirschner N, Haftek M, Niessen CM, Behne MJ, Furuse M, Moll I, Brandner JM, CD44 regulates tight-junction assembly and barrier function. J Invest Dermatol. 2011 Apr;131(4):932-43
1	J:167016 Kobayashi K, Yasui M, Cellular and subcellular localization of aquaporins 1, 3, 8, and 9 in amniotic membranes during pregnancy in mice. Cell Tissue Res. 2010 Nov;342(2):307-16
3	J:208053 Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ, Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering. J Pathol. 2014 Apr;232(5):541-52
2	J:71581 Kostka G, Giltay R, Bloch W, Addicks K, Timpl R, Fassler R, Chu ML, Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001 Oct;21(20):7025-34
1	J:168590 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE, Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010 Dec 14;19(6):807-18
1	J:277726 Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C, Epidermal development requires ninein for spindle orientation and cortical microtubule organization. Life Sci Alliance. 2019 Apr;2(2)
1*	J:255485 Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK, Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427
1	J:194053 Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y, Xu GL, Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
2	J:296151 Liu J, Chanumolu SK, White KM, Albahrani M, Otu HH, Nawshad A, Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
2	J:267455 Liu XD, Zhu XN, Halford MM, Xu TL, Henkemeyer M, Xu NJ, Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1. J Cell Biol. 2018 Nov 5;217(11):4007-4024
4	J:138245 Lopardo T, Lo Iacono N, Marinari B, Giustizieri ML, Cyr DG, Merlo G, Crosti F, Costanzo A, Guerrini L, Claudin-1 is a p63 target gene with a crucial role in epithelial development. PLoS One. 2008;3(7):e2715
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2	J:345312 Mak S, Hammes A, Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)
1*	J:341326 Nag P, Inubushi T, Sasaki JI, Murotani T, Kusano S, Nakanishi Y, Shiraishi Y, Kurosaka H, Imazato S, Yamaguchi Y, Yamashiro T, Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse. J Dent Res. 2023 Sep;102(10):1162-1171
4	J:309378 Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD, Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Nov;32(11):2219-2231
1*	J:72106 Niimi T, Nagashima K, Ward JM, Minoo P, Zimonjic DB, Popescu NC, Kimura S, claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
1	J:170867 Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP, p120-Catenin is required for mouse vascular development. Circ Res. 2010 Mar 19;106(5):941-51
4*	J:116647 Ohazama A, Sharpe PT, Expression of claudins in murine tooth development. Dev Dyn. 2007 Jan;236(1):290-4
5*	J:107229 Ohta H, Adachi H, Inaba M, Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J Vet Med Sci. 2006 Feb;68(2):149-55
1	J:180511 Patel RM, Myers LS, Kurundkar AR, Maheshwari A, Nusrat A, Lin PW, Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol. 2012 Feb;180(2):626-35
1	J:200244 Roth W, Kumar V, Beer HD, Richter M, Wohlenberg C, Reuter U, Thiering S, Staratschek-Jox A, Hofmann A, Kreusch F, Schultze JL, Vogl T, Roth J, Reichelt J, Hausser I, Magin TM, Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci. 2012 Nov 15;125(Pt 22):5269-79
1	J:265031 Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM, Immunomodulatory role of Keratin 76 in oral and gastric cancer. Nat Commun. 2018 Aug 24;9(1):3437
2	J:218919 Sumigray K, Zhou K, Lechler T, Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. PLoS One. 2014;9(7):e101824
3	J:261068 Szabo R, Bugge TH, Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy. PLoS One. 2018;13(4):e0194660
3	J:221394 Szabo R, Peters DE, Kosa P, Camerer E, Bugge TH, Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014 Jul;10(7):e1004470
1	J:144091 Tinkle CL, Pasolli HA, Stokes N, Fuchs E, New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15405-10
1*	J:75463 Traweger A, Fang D, Liu YC, Stelzhammer W, Krizbai IA, Fresser F, Bauer HC, Bauer H, The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch. J Biol Chem. 2002 Mar 22;277(12):10201-8
6*	J:117802 Troy TC, Li Y, O'malley L, Turksen K, The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice. Gene Expr Patterns. 2007 Feb;7(4):423-30
2	J:97223 Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM, E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005 Mar 23;24(6):1146-56
3	J:268062 Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessey BA, Spencer TE, Lydon JP, DeMayo FJ, FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS Genet. 2018 Nov;14(11):e1007787
1	J:302296 Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, Hui JHL, Jiang L, Kwan KM, SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2009568118
8*	J:181271 Westmoreland JJ, Drosos Y, Kelly J, Ye J, Means AL, Washington MK, Sosa-Pineda B, Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
1	J:183127 Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B, Pancreas-specific deletion of prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology. 2012 Apr;142(4):999-1009.e6
2	J:199582 Youssef G, Gerner L, Naeem AS, Ralph O, Ono M, O'Neill CA, O'Shaughnessy RF, Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition. Dev Biol. 2013 Aug 15;380(2):274-85
1	J:321983 Yu Y, Zhang B, Ji P, Zuo Z, Huang Y, Wang N, Liu C, Liu SJ, Zhao F, Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. Nat Commun. 2022 Mar 3;13(1):1151
2	J:114626 Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN, Roop DR, Wertz P, Andersen B, The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol. 2006 Nov 1;299(1):122-36
1	J:243534 Zhang Y, Xie S, Zhou Y, Xie Y, Liu P, Sun M, Xiao H, Jin Y, Sun X, Chen Z, Huang Q, Chen S, H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm. Cell Rep. 2014 Sep 25;8(6):1989-2002