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Gck Gene Detail
Summary
  • Symbol
    Gck
  • Name
    glucokinase
  • Synonyms
    Gls006, hexokinase 4, HK4, Hlb62, MODY2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270854
    NCBI Gene: 103988
  • Gene Overview
    MyGene.info: GCK
Location & Maps
more
  • Sequence Map
    Chr11:5900820-5950081 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    GCK, glucokinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GCK, glucokinase
    Orthology source: HomoloGene
  • Synonyms
    FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
  • Links
    NCBI Gene ID: 2645
    neXtProt AC: NX_P35557

  • Chr Location
    7p15.3-p15.1; chr7:44144271-44189423 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Gck mouse models; 4 with human GCK associations

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 2 models
Maturity-Onset Diabetes of the Young, Type 2; MODY2   OMIM: 125851 View 29 models
       Hyperinsulinemic Hypoglycemia, Familial, 2; HHF2   OMIM: 601820 View 1 model
       Diabetes Mellitus, Permanent Neonatal; PNDM   OMIM: 606176
Hyperinsulinemic Hypoglycemia, Familial, 3; HHF3   OMIM: 602485
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    21 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 28 alleles in 21 genetic backgrounds
    16 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (ENU)
    19
  • Gene trapped
    5
  • Targeted
    11
  • Incidental Mutations
Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006327 VEGA Gene Model | MGI Sequence Detail 49262 C57BL/6J ±  kb
transcript OTTMUST00000014373 VEGA | MGI Sequence Detail 2727 Not Applicable  
polypeptide OTTMUSP00000006667 VEGA | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    97 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    Genomic 21
    cDNA 20
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2678682, MGI:4357923
References
more
  • Summaries
    All 118
    Developmental Gene Expression 25
    Diseases 10
    Gene Ontology 26
    Phenotypes 45
  • Earliest
    J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
  • Latest
    J:233745 Ferrell JM, et al., Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016 Jul;57(7):1144-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory