Gck
Gene Detail

Symbol Name ID

Gck glucokinase MGI:1270854

Synonyms

Gk, Gls006, hexokinase 4, HK4, MODY2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:5900820-5950081 bp, - strand From VEGA annotation of GRCm38   49262 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: hexokinase
Gene Tree: Gck

Human homologs

Human Homolog		GCK, glucokinase (hexokinase 4)
NCBI Gene ID		2645
neXtProt AC		NX_P35557
Human Synonyms		FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Human Chr (Location)		7p15.3-p15.1; chr7:44183870-44229022 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human GCK

Alleles and phenotypes

All alleles(30) : Targeted(10) Gene trapped(5) Chemically induced(15)
 

Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.

 
Human Diseases Modeled Using Mouse Gck (3)    Alleles Annotated to Human Diseases(21)   

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	calcium ion import, carbohydrate metabolic process, ...
Component	actin filament, cell cortex, ...
Function	ADP binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (317)    Tissues (146)    Images (25)
Theiler Stages: 15, 22, 23, 24, 28

Assay Type	Results
RNA in situ	219
Western blot	2
RT-PCR	96

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(21) cDNA(20) Primer pair(5) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006327 (Evidence)
Ensembl Gene Model	ENSMUSG00000041798 (Evidence)
Entrez Gene	103988 (Evidence)
UniGene	220358
DFCI	TC1585582, TC1641456
DoTS	DT.489489, DT.94187311
NIA Mouse Gene Index	U032478
EC	2.7.1.2
Consensus CDS Project	CCDS24409.1
International Mouse Knockout Project Status	Gck

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006327	VEGA Gene Model | MGI Sequence Detail	49262	C57BL/6J
transcript	OTTMUST00000014370	VEGA | MGI Sequence Detail	2361	Not Applicable
polypeptide	OTTMUSP00000006664	VEGA | MGI Sequence Detail	465	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001312	Hexokinase
InterPro	IPR019807	Hexokinase, conserved site
InterPro	IPR022673	Hexokinase, C-terminal
InterPro	IPR022672	Hexokinase, N-terminal
Protein Ontology	PR:000007895	glucokinase

References

(Earliest) J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
(Latest) J:194286 Wang R, et al., Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice. Gene. 2013 Mar 10;516(2):248-54
All references(102)

Other accession IDs

MGI:4357923