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Gck
Gene Detail
 Symbol
Name
ID
Gck
glucokinase
MGI:1270854
Synonyms Gk, Gls006, hexokinase 4, HK4, MODY2
Feature Type protein coding gene
Genetic Map
Chromosome 11
3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:5900820-5950081 bp, - strand
From VEGA annotation of GRCm38

  49262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: hexokinase
Gene Tree: Gck

Human
homologs
Human Homolog GCK, glucokinase (hexokinase 4)
NCBI Gene ID 2645
neXtProt AC  NX_P35557
Human Synonyms  FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Human Chr (Location)  7p15.3-p15.1; chr7:44144271-44189423 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human GCK
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Chemically induced (ENU)(17) Gene trapped(5) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.
 
Human Diseases Modeled Using Mouse Gck (3)    Alleles Annotated to Human Diseases(21)   
Interactions
Gck interacts with 124 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (78 annotations)
Process calcium ion import, carbohydrate metabolic process, ...
Component actin filament, basal cortex, ...
Function ADP binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (317)    Tissues (146)    Images (25)
Theiler Stages: 15, 22, 23, 24, 28
Assay TypeResults
RNA in situ 219
Western blot 2
RT-PCR 96
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(21) cDNA(20) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006327 (Evidence)
Ensembl Gene ModelENSMUSG00000041798 (Evidence)
Entrez Gene103988 (Evidence)
UniGene220358
DFCITC1585582, TC1641456
DoTSDT.489489, DT.94187311
NIA Mouse Gene IndexU032478
EC2.7.1.2
Consensus CDS ProjectCCDS24409.1, CCDS70135.1
International Mouse Knockout Project StatusGck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006327 VEGA Gene Model | MGI Sequence Detail 49262 C57BL/6J ±  kb
transcript OTTMUST00000014370 VEGA | MGI Sequence Detail 2361 Not Applicable 
polypeptide OTTMUSP00000006664 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(9) UniProt(5)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001312 Hexokinase
InterPro IPR019807 Hexokinase, conserved site
InterPro IPR022673 Hexokinase, C-terminal
InterPro IPR022672 Hexokinase, N-terminal
Protein Ontology PR:000007895 glucokinase
References (Earliest) J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
(Latest) J:210651 Gimenez-Cassina A, et al., Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 2014 Feb 4;19(2):272-84
All references(110)
Disease annotation references (9)
Other
accession IDs
MGI:4357923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory