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Gck Gene Detail
Summary
  • Symbol
    Gck
  • Name
    glucokinase
  • Synonyms
    Gls006, hexokinase 4, HK4, Hlb62, MODY2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270854
    NCBI Gene: 103988
  • Gene Overview
    MyGene.info: GCK
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5900820-5950081 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270854
protein coding gene Chr11:5900816-5950081 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018012
protein coding gene Chr11:2987565-3044533 (-)
A/J MGP_AJ_G0017985
protein coding gene Chr11:2870713-2922435 (-)
AKR/J MGP_AKRJ_G0017949
protein coding gene Chr11:3020092-3070946 (-)
BALB/cJ MGP_BALBcJ_G0017953
protein coding gene Chr11:2863091-2910994 (-)
C3H/HeJ MGP_C3HHeJ_G0017766
protein coding gene Chr11:2893851-2946268 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018405
protein coding gene Chr11:3070972-3123012 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016063
protein coding gene Chr11:2770872-2820234 (-)
CAST/EiJ MGP_CASTEiJ_G0017328
protein coding gene Chr11:2862845-2919185 (-)
CBA/J MGP_CBAJ_G0017741
protein coding gene Chr11:3440853-3505866 (-)
DBA/2J MGP_DBA2J_G0017851
protein coding gene Chr11:2777101-2827113 (-)
FVB/NJ MGP_FVBNJ_G0017843
protein coding gene Chr11:2802183-2854053 (-)
LP/J MGP_LPJ_G0017922
protein coding gene Chr11:3067041-3119602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017869
protein coding gene Chr11:3038253-3104463 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018445
protein coding gene Chr11:3026120-3086654 (-)
PWK/PhJ MGP_PWKPhJ_G0017108
protein coding gene Chr11:2802229-2851425 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016905
protein coding gene Chr11:2992503-3043524 (-)
WSB/EiJ MGP_WSBEiJ_G0017382
protein coding gene Chr11:2866759-2919047 (-)



Homology
more
  • Human Ortholog
    GCK, glucokinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GCK, glucokinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
  • Links
    NCBI Gene ID: 2645
    neXtProt AC: NX_P35557
    UniProt: P35557

  • Chr Location
    7p13; chr7:44143213-44189439 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55440
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GCK
  • Protein SuperFamily
  • Gene Tree
    Gck
Human Diseases
more
  • Diseases
    3 with Gck mouse models; 3 with human GCK associations

Human Disease Mouse Models
      
IDs
View 29 models
IDs
View 2 models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    21 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 29 alleles in 22 genetic backgrounds
    16 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041798 Ensembl Gene Model | MGI Sequence Detail 49262 C57BL/6J ±  kb
    transcript ENSMUST00000109823 Ensembl | MGI Sequence Detail 2361 Not Applicable  
    polypeptide ENSMUSP00000105448 Ensembl | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 21
      cDNA 21
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2678682, MGI:4357923
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 32
      Diseases 10
      Gene Ontology 26
      Phenotypes 50
    • Earliest
      J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
    • Latest
      J:257792 Basco D, et al., alpha-cell glucokinase suppresses glucose-regulated glucagon secretion. Nat Commun. 2018 Feb 7;9(1):546

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory