About   Help   FAQ
Gck
Gene Detail
Symbol

Name
ID
Gck
glucokinase
MGI:1270854
Synonyms
Gk, Gls006, hexokinase 4, HK4, Hlb62, MODY2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:5900820-5950081 bp, - strand
From VEGA annotation of GRCm38

  49262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55440  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GCK
Protein SuperFamily: hexokinase
Gene Tree: Gck

Human
homologs
GCK, glucokinase (hexokinase 4)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2645
neXtProt AC: NX_P35557

Human Synonyms: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2

Human Chr (Location): 7p15.3-p15.1; chr7:44144271-44189423 (-)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human GCK

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Chemically induced (ENU)(19) Gene trapped(5) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.
 
Human Diseases Modeled in Mice Using Gck (3)    Mutations Annotated to Human Diseases (21)   
Interactions
Gck interacts with 123 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process calcium ion import, carbohydrate metabolic process, ...
Component actin filament, basal cortex, ...
Function ADP binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (317)    Tissues (146)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 219
Western blot 2
RT-PCR 96
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gck    NEW 
Molecular
reagents
All nucleic(47) Genomic(21) cDNA(20) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006327 (Evidence)
Ensembl Gene Model ENSMUSG00000041798 (Evidence)
Entrez Gene 103988 (Evidence)
UniGene 220358
DFCI TC1585582, TC1641456
DoTS DT.94187311, DT.489489
NIA Mouse Gene Index U032478
EC 2.7.1.1, 2.7.1.2
Consensus CDS Project CCDS24409.1, CCDS70135.1
International Mouse Phenotyping Consortium Status Gck
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006327 VEGA Gene Model | MGI Sequence Detail 49262 C57BL/6J ±  kb
transcript OTTMUST00000014370 VEGA | MGI Sequence Detail 2361 Not Applicable 
polypeptide OTTMUSP00000006664 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(5)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001312 Hexokinase
InterPro IPR019807 Hexokinase, conserved site
InterPro IPR022673 Hexokinase, C-terminal
InterPro IPR022672 Hexokinase, N-terminal
Protein Ontology PR:000007895 glucokinase
References
(Earliest) J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
(Latest) J:214141 Ciciotte SL, et al., 3-Dimensional histological reconstruction and imaging of the murine pancreas. Mamm Genome. 2014 Oct;25(9-10):539-48
All references(119)
Disease annotation references (9)
Other
accession IDs
MGI:2678682, MGI:4357923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory