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Gck Gene Detail
Summary
  • Symbol
    Gck
  • Name
    glucokinase
  • Synonyms
    Gls006, hexokinase 4, HK4, Hlb62, MODY2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270854
    NCBI Gene: 103988
  • Gene Overview
    MyGene.info: GCK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:5900820-5950081 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.88 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    GCK, glucokinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GCK, glucokinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
  • Links
    NCBI Gene ID: 2645
    neXtProt AC: NX_P35557
    UniProt: P35557

  • Chr Location
    7p13; chr7:44143213-44189439 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55440
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GCK
  • Protein SuperFamily
  • Gene Tree
    Gck
Human Diseases
more
  • Diseases
    3 with Gck mouse models; 4 with human GCK associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 29 models
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    21 with disease annotations
  • References
    10 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 28 alleles in 21 genetic backgrounds
    16 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted disruption of this gene causes mild hyperglycemia in heterozygous mice and extreme hyperglycemia and embryonic to postnatal lethality in homozygous mice. Hyperglycemic knock-out or ENU-induced mutants may show reduced body weight and liver glycogen level, hepatic steatosis, and glucosuria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006327 VEGA Gene Model | MGI Sequence Detail 49262 C57BL/6J ±  kb
    transcript OTTMUST00000014370 VEGA | MGI Sequence Detail 2361 Not Applicable  
    polypeptide OTTMUSP00000006664 VEGA | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      97 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 21
      cDNA 21
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2678682, MGI:4357923
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 32
      Diseases 10
      Gene Ontology 25
      Phenotypes 49
    • Earliest
      J:5824 Coleman DL, Genetic control of glucokinase activity in mice. Biochem Genet. 1977 Apr;15(3-4):297-305
    • Latest
      J:257792 Basco D, et al., alpha-cell glucokinase suppresses glucose-regulated glucagon secretion. Nat Commun. 2018 Feb 7;9(1):546

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory