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Prom1
Gene Detail
Symbol

Name
ID
Prom1
prominin 1
MGI:1100886
STS
Synonyms
4932416E19Rik, AC133, CD133, Prom, Prom-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
23.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:43993625-44102032 bp, - strand
From Ensembl annotation of GRCm38

  108408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prominin
Gene Tree: Prom1

Human
homologs
Human Homolog   PROM1, prominin 1
NCBI Gene ID 8842
neXtProt AC  NX_O43490
Human Synonyms  AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4
Human Chr (Location)  4p15.32; chr4:15968226-16084059 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human PROM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Radiation induced(2) Spontaneous(1) Targeted(5)
Genomic Mutations involving Prom1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal retina morphology, vasculature, and electrophysiology.
 
Human Diseases Modeled in Mice Using Prom1 (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Prom1 interacts with 185 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (43 records)
Data Summary: Results (30)    Tissues (23)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 5
Northern blot 2
Western blot 4
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Other(1)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029086 Ensembl Gene Model | MGI Sequence Detail 108408 C57BL/6J ±  kb
transcript ENSMUST00000074113 Ensembl | MGI Sequence Detail 3743 Not Applicable 
polypeptide ENSMUSP00000073751 Ensembl | MGI Sequence Detail 867 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(36) UniProt(6)
Polymorphisms
SNPs within 2kb(836 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008795 Prominin
Protein Ontology PR:000001786 prominin-1
References
(Earliest) J:44182 Weigmann A, et al., Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12425-30
(Latest) J:215591 Chang B, et al., A New Mouse Model of Retinal Degeneration (RD19). 2014;
All references(79)
Disease annotation references (2)
Other
accession IDs
MGI:2444952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory