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Prom1
Gene Detail
Symbol

Name
ID
Prom1
prominin 1
MGI:1100886
STS
Synonyms
4932416E19Rik, AC133, CD133, Prom, Prom-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
23.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:43993625-44102032 bp, - strand
From Ensembl annotation of GRCm38

  108408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prominin
Gene Tree: Prom1

Human
homologs
Human Homolog PROM1, prominin 1
NCBI Gene ID 8842
neXtProt AC  NX_O43490
Human Synonyms  AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4
Human Chr (Location)  4p15.32; chr4:15968226-16084059 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human PROM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Radiation induced(1) Spontaneous(1) Targeted(5)
Genomic Mutations involving Prom1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal retina morphology, vasculature, and electrophysiology.
 
Human Diseases Modeled Using Mouse Prom1 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Prom1 interacts with 185 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (42 records)
Data Summary: Results (30)    Tissues (23)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 5
Northern blot 2
Western blot 4
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Other(1)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029086 Ensembl Gene Model | MGI Sequence Detail 108408 C57BL/6J ±  kb
transcript ENSMUST00000074113 Ensembl | MGI Sequence Detail 3743 Not Applicable 
polypeptide ENSMUSP00000073751 Ensembl | MGI Sequence Detail 867 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(41) UniProt(11)
Polymorphisms
SNPs within 2kb(836 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008795 Prominin
Protein Ontology PR:000001786 prominin-1
References
(Earliest) J:44182 Weigmann A, et al., Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12425-30
(Latest) J:215591 Chang B, et al., A New Mouse Model of Retinal Degeneration (RD19). 2014;
All references(78)
Disease annotation references (2)
Other
accession IDs
MGI:2444952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory