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Prom1
Gene Detail
 Symbol
Name
ID
Prom1
prominin 1
MGI:1100886
STS D5Dmo7
Synonyms 4932416E19Rik, AC133, CD133, Prom, Prom-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
23.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:43993622-44101736 bp, - strand
From NCBI annotation of GRCm38

  108115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4390  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prominin
Gene Tree: Prom1

Human
homologs
Human Homolog PROM1, prominin 1
NCBI Gene ID 8842
neXtProt AC  NX_O43490
Human Synonyms  AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4
Human Chr (Location)  4p15.32; chr4:15968226-16084059 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human PROM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(5)
Genomic Mutations involving Prom1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal retina morphology, vasculature, and electrophysiology.
 
Human Diseases Modeled Using Mouse Prom1 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Prom1 interacts with 185 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process camera-type eye photoreceptor cell differentiation, glomerular parietal epithelial cell differentiation, ...
Component apical plasma membrane, brush border, ...
Function actinin binding, cadherin binding
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (30)    Tissues (23)    Images (12)
Theiler Stages: 11, 13, 14, 16, 20, 24, 28
Assay TypeResults
Immunohistochemistry 19
RNA in situ 5
Northern blot 2
Western blot 4
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029086 (Evidence)
Entrez Gene19126 (Evidence)
DFCITC1579311, TC1589026, TC1589739, TC1594227, TC1628278
DoTSDT.101177403, DT.101382432, DT.101382433, DT.101735416, DT.101735417, DT.40144739, DT.94136818, DT.99842816
Consensus CDS ProjectCCDS39082.1, CCDS51491.1, CCDS51492.1, CCDS51493.1, CCDS51494.1, CCDS51495.1
International Mouse Knockout Project StatusProm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19126 NCBI Gene Model | MGI Sequence Detail 108115 C57BL/6J ±  kb
transcript NM_001163577 RefSeq | MGI Sequence Detail 3766 C57BL/6 
polypeptide O54990 UniProt | EBI | MGI Sequence Detail 867 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(41) UniProt(7)
Polymorphisms SNPs within 2kb(832 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008795 Prominin
Protein Ontology PR:000001786 prominin-1
Graphical View of Protein Domain Structure
References (Earliest) J:44182 Weigmann A, et al., Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12425-30
(Latest) J:202344 Lesko MH, et al., Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol. 2013 Oct 1;382(1):15-26
All references(75)
Disease annotation references (1)
Other
accession IDs
MGI:2444952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory