Prom1^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Prom1^tm1Pec
• Name: prominin 1; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:3838534
• Gene: Prom1 Location: Chr5:44150962-44259374 bp, - strand Genetic Position: Chr5, 23.97 cM
• Alliance: Prom1^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146585
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.6 kb fragment encompassing exon 2 was replaced with a floxed neo cassette via homologous recombination. In situ hybridization analysis confirmed the absence of mRNA expression in retinas from homozygous mice. (J:146585)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prom1 Mutation: 75 strains or lines available

References

• Original: J:146585 Zacchigna S, et al., Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci. 2009 Feb 18;29(7):2297-308
• All: 6 reference(s)