Analysis Tools
vision/eye
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• retinal gliosis is detected at P20
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• by 6 months of age the diameters of large vessels and the capillary density are reduced
• however, no differences in retinal vasculature are detected in mice at 1 month of age
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• degeneration of both rod and cone outer segments occurs simultaneously
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• disorganized distribution of cone opsin with abnormal accumulation in the outer nuclear layer
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• at P12 disk membranes are underdeveloped and morphologically abnormal
• after P20 disorganization of disk membranes becomes progressively worse
• by 7 months of age virtually no normal outer segments are present
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• at P20 the outer segment is shorter than normal
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• ectopic localization of rhodosin at P20
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• at P12 disk membranes are underdeveloped and morphologically abnormal
• after P20 disorganization of disk membranes becomes progressively worse
• by 7 months of age virtually no normal outer segments are present
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• by P15 increased apoptosis is seen in the outer nuclear layer with most photoreceptors in the outer nuclear layer apoptotic by P20
• increase in apoptosis is independent of light exposure
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• at 6 months of age retinal pigment epithelial cells are slightly abnormal but present
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• loss of retinal pigmentation is seen in several areas of the retina at 6 months of age
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• progressive degeneration of the outer nuclear layer starting after P15
• by 6 months of age only 2 or 3 rows of photoreceptors remain in the outer nuclear layer
• by 12 months of age the outer nuclear layer is absent
• no significant changes are seen in any layer of the retina other than the outer nuclear layer
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• at 1 month of age the amplitude of the cone responses is reduced by about 50% compared to controls and the sensitivity of these responses is also reduced
• at 6 months of age cone responses are almost completely absent
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• at 1 month of age at low light intensities the amplitude of rod response is reduced by about 50% compared to controls and the amplitude peak is shifted to the right indicating decreased sensitivity of the rods
• at 1 month of age at higher light intensities the regular a-wave is absent and the oscillatory potentials are reduced
• at 6 months of age rod responses are almost completely absent
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cardiovascular system
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• by 6 months of age the diameters of large vessels and the capillary density are reduced
• however, no differences in retinal vasculature are detected in mice at 1 month of age
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nervous system
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• degeneration of both rod and cone outer segments occurs simultaneously
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• disorganized distribution of cone opsin with abnormal accumulation in the outer nuclear layer
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• after P20 disorganization of disk membranes becomes progressively worse
• by 7 months of age virtually no normal outer segments are present
• at P12 disk membranes are underdeveloped and morphologically abnormal
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• at P20 the outer segment is shorter than normal
|
|
• ectopic localization of rhodosin at P20
|
|
• at P12 disk membranes are underdeveloped and morphologically abnormal
• after P20 disorganization of disk membranes becomes progressively worse
• by 7 months of age virtually no normal outer segments are present
|
|
• by P15 increased apoptosis is seen in the outer nuclear layer with most photoreceptors in the outer nuclear layer apoptotic by P20
• increase in apoptosis is independent of light exposure
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pigmentation
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• at 6 months of age retinal pigment epithelial cells are slightly abnormal but present
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• loss of retinal pigmentation is seen in several areas of the retina at 6 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 41 | DOID:0110376 |
OMIM:612095 |
J:146585 | |
