About   Help   FAQ
Crebbp
Gene Detail
 Symbol
Name
ID
Crebbp
CREB binding protein
MGI:1098280
Synonyms CBP, KAT3A
Feature Type protein coding gene
Genetic Map
Chromosome 16
2.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:4084048-4213404 bp, - strand
From NCBI annotation of GRCm38

  129357 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: transcription coactivator CREB-binding protein
Gene Tree: Crebbp

Human
homologs
Human Homolog CREBBP, CREB binding protein
NCBI Gene ID 1387
neXtProt AC  NX_Q92793
Human Synonyms  CBP, KAT3A, RSTS
Human Chr (Location)  16p13.3; chr16:3725054-3880120 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CREBBP
Alleles
and
phenotypes
All alleles(32) : Gene trapped(20) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null or altered alleles die around midgestation with defects in hemopoiesis, blood vessel formation, and neural tube closure. Heterozygotes may exhibit skeletal, cardiac, and hematopoietic defects, retarded growth, and hematologic tumors.
 
Human Diseases Modeled Using Mouse Crebbp (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process cell proliferation, germ-line stem cell maintenance, ...
Component condensed chromosome outer kinetochore, cytoplasm, ...
Function acetyltransferase activity, activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (45)    Tissues (42)    Images (8)
Theiler Stages: 5, 12, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 30
Western blot 4
RT-PCR 11
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022521 (Evidence)
Entrez Gene12914 (Evidence)
DFCITC1597060, TC1636155
DoTSDT.103585853, DT.94131253
NIA Mouse Gene IndexU036730, U036732
EC2.3.1.48
PDB1JJS, 1KBH, 1KDX, 1L8C, 1R8U, 1TOT, 1U2N, 2AGH, 2KKJ, 2LQH, 2LQI, 2LWW, 4I9O, 1F81, 1SB0, 2C52, 2KA4, 2KA6, 2L14
Consensus CDS ProjectCCDS27915.1
International Mouse Knockout Project StatusCrebbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12914 NCBI Gene Model | MGI Sequence Detail 129357 C57BL/6J ±  kb
transcript NM_001025432 RefSeq | MGI Sequence Detail 7507 C57BL/6 
polypeptide P45481 UniProt | EBI | MGI Sequence Detail 2441 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(303 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR003101 Coactivator CBP, KIX domain
InterPro IPR010303 Domain of unknown function DUF902, CREBbp
InterPro IPR013178 Histone H3-K56 acetyltransferase, RTT109
InterPro IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR000197 Zinc finger, TAZ-type
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000000090 creb-binding protein
Graphical View of Protein Domain Structure
References (Earliest) J:34578 Chrivia JC, et al., Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9
(Latest) J:205332 Tsui D, et al., CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. Dev Biol. 2014 Jan 15;385(2):230-41
All references(180)
Other
accession IDs
MGI:2146668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory