Crebbp
Gene Detail

Symbol Name ID

Crebbp CREB binding protein MGI:1098280

Synonyms

CBP, KAT3A

Feature Type

protein coding gene

Genetic Map

Chromosome 16

2.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:4084048-4213404 bp, - strand From NCBI annotation of GRCm38   129357 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: transcription coactivator CREB-binding protein
Gene Tree: Crebbp

Human homologs

Human Homolog		CREBBP, CREB binding protein
NCBI Gene ID		1387
neXtProt AC		NX_Q92793
Human Synonyms		CBP, KAT3A, RSTS
Human Chr (Location)		16p13.3; chr16:3775055-3930121 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CREBBP

Alleles and phenotypes

All alleles(32) : Targeted(12) Gene trapped(20)
 

Homozygotes for null or altered alleles die around midgestation with defects in hemopoiesis, blood vessel formation, and neural tube closure. Heterozygotes may exhibit skeletal, cardiac, and hematopoietic defects, retarded growth, and hematologic tumors.

 
Human Diseases Modeled Using Mouse Crebbp (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (81 annotations)

Process	cell proliferation, germ-line stem cell maintenance, ...
Component	condensed chromosome outer kinetochore, cytoplasm, ...
Function	acetyltransferase activity, activating transcription factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)
Data Summary: Results (45)    Tissues (43)    Images (8)
Theiler Stages: 5, 12, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	30
Western blot	4
RT-PCR	11

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022521 (Evidence)
Entrez Gene	12914 (Evidence)
DFCI	TC1597060, TC1636155
DoTS	DT.103585853, DT.94131253
NIA Mouse Gene Index	U036730, U036732
EC	2.3.1.48
PDB	1JJS, 1KBH, 1KDX, 1L8C, 1R8U, 1TOT, 1U2N, 2AGH, 2KKJ, 2LQH, 2LQI, 4I9O, 1F81, 1SB0, 2C52, 2KA4, 2KA6, 2L14
Consensus CDS Project	CCDS27915.1
International Mouse Knockout Project Status	Crebbp

Sequences

Length	Strain/Species
genomic	12914	NCBI Gene Model | MGI Sequence Detail	129357	C57BL/6J
transcript	NM_001025432	RefSeq | MGI Sequence Detail	7507	C57BL/6
polypeptide	P45481	UniProt | EBI | MGI Sequence Detail	2441	Not Applicable

All sequences(34) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(243 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR003101	Coactivator CBP, KIX domain
InterPro	IPR010303	Domain of unknown function DUF902, CREBbp
InterPro	IPR013178	Histone H3-K56 acetyltransferase, RTT109
InterPro	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking
InterPro	IPR009110	Nuclear receptor coactivator, interlocking
InterPro	IPR000197	Zinc finger, TAZ-type
InterPro	IPR000433	Zinc finger, ZZ-type
Protein Ontology	PR:000000090	creb-binding protein
Protein Ontology	PR:000027107	creb-binding protein (mouse)

Graphical View of Protein Domain Structure

References

(Earliest) J:34578 Chrivia JC, et al., Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9
(Latest) J:192675 Wang J, et al., Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell. 2012 Jul 6;11(1):23-35
All references(171)

Other accession IDs

MGI:2146668