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Crebbp
Gene Detail
 Symbol
Name
ID
Crebbp
CREB binding protein
MGI:1098280
Synonyms CBP, KAT3A
Feature Type protein coding gene
Genetic Map
Chromosome 16
2.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:4081328-4213407 bp, - strand
From VEGA annotation of GRCm38

  132080 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: transcription coactivator CREB-binding protein
Gene Tree: Crebbp

Human
homologs
Human Homolog CREBBP, CREB binding protein
NCBI Gene ID 1387
neXtProt AC  NX_Q92793
Human Synonyms  CBP, KAT3A, RSTS
Human Chr (Location)  16p13.3; chr16:3725054-3880120 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CREBBP
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(20) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null or altered alleles die around midgestation with defects in hemopoiesis, blood vessel formation, and neural tube closure. Heterozygotes may exhibit skeletal, cardiac, and hematopoietic defects, retarded growth, and hematologic tumors.
 
Human Diseases Modeled Using Mouse Crebbp (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (93 annotations)
Process cell proliferation, germ-line stem cell maintenance, ...
Component condensed chromosome outer kinetochore, cytoplasm, ...
Function acetyltransferase activity, activating transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (45)    Tissues (42)    Images (8)
Theiler Stages: 5, 12, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 30
Western blot 4
RT-PCR 11
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048175 (Evidence)
Ensembl Gene ModelENSMUSG00000022521 (Evidence)
Entrez Gene12914 (Evidence)
DFCITC1597060, TC1636155
DoTSDT.103585853, DT.94131253
NIA Mouse Gene IndexU036730, U036732
EC2.3.1.48
PDB1JJS, 1KBH, 1KDX, 1L8C, 1R8U, 1TOT, 1U2N, 2AGH, 2KKJ, 2LQH, 2LQI, 2LWW, 4I9O, 1F81, 1SB0, 2C52, 2KA4, 2KA6, 2L14
Consensus CDS ProjectCCDS27915.1
International Mouse Knockout Project StatusCrebbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048175 VEGA Gene Model | MGI Sequence Detail 132080 C57BL/6J ±  kb
transcript OTTMUST00000123704 VEGA | MGI Sequence Detail 10230 Not Applicable 
polypeptide OTTMUSP00000067477 VEGA | MGI Sequence Detail 2441 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(308 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR003101 Coactivator CBP, KIX domain
InterPro IPR010303 Domain of unknown function DUF902, CREBbp
InterPro IPR013178 Histone H3-K56 acetyltransferase, RTT109
InterPro IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR000197 Zinc finger, TAZ-type
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000000090 creb-binding protein
References (Earliest) J:34578 Chrivia JC, et al., Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9
(Latest) J:205332 Tsui D, et al., CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. Dev Biol. 2014 Jan 15;385(2):230-41
All references(182)
Disease annotation references (5)
Other
accession IDs
MGI:2146668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory