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Sftpc Gene Detail
Summary
  • Symbol
    Sftpc
  • Name
    surfactant associated protein C
  • Synonyms
    Bricd6, pro-SpC, Sftp2, Sftp-2, SPC, SP-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:109517
    NCBI Gene: 20389
Location & Maps
more
  • Sequence Map
    Chr14:70520941-70524081 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3141 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    SFTPC, surfactant protein C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SFTPC, surfactant protein C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRICD6, PSP-C, SFTP2, SMDP2, SP-C
  • Links
    NCBI Gene ID: 6440
    neXtProt AC: NX_P11686

  • Chr Location
    8p21; chr8:22161671-22164479 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Sftpc mouse models; 2 with human SFTPC associations

Human Disease Mouse Models
       Interstitial Pneumonitis, Desquamative, Familial; DIP   OMIM: 263000 View 1 model
       Pulmonary Fibrosis, Idiopathic; IPF   OMIM: 178500
Surfactant Metabolism Dysfunction, Pulmonary, 2; SMDP2   OMIM: 610913
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    1 involving Sftpc
  • Incidental Mutations
Mice homozygous for disruptions in this gene display respiratory abnormalities similar to emphysema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20389 NCBI Gene Model | MGI Sequence Detail 3141 C57BL/6J ±  kb
transcript NM_011359 RefSeq | MGI Sequence Detail 804 C57BL/6  
polypeptide NP_035489 RefSeq | MGI Sequence Detail 193 C57BL/6  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014774 pulmonary surfactant-associated protein C
  • InterPro Domains
    IPR007084 BRICHOS domain
    IPR001729 Pulmonary surfactant-associated protein C
    IPR018051 Surfactant-associated polypeptide, palmitoylation site
    IPR015091 Surfactant protein C, N-terminal propeptide
Molecular
Reagents
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  • All nucleic 930
    Genomic 1
    cDNA 908
    Primer pair 13
    Other 8

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14378, MGD-MRK-14381, MGD-MRK-39516
References
more
  • Summaries
    All 278
    Developmental Gene Expression 238
    Diseases 1
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:10878 Glasser SW, et al., Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem. 1990 Dec 15;265(35):21986-91
  • Latest
    J:228894 Coles GL, et al., KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet. 2015 Oct;11(10):e1005525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory