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Sftpc Gene Detail
Summary
  • Symbol
    Sftpc
  • Name
    surfactant associated protein C
  • Synonyms
    Bricd6, pro-SpC, Sftp2, Sftp-2, SPC, SP-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:109517
    NCBI Gene: 20389
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:70520949-70524081 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3133 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.32 cM
  • Mapping Data
    4 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    SFTPC, surfactant protein C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SFTPC, surfactant protein C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRICD6, PSP-C, SFTP2, SMDP2, SP-C
  • Links
    NCBI Gene ID: 6440
    neXtProt AC: NX_P11686
    UniProt: P11686

  • Chr Location
    8p21.3; chr8:22161671-22164479 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Sftpc mouse models; 1 with human SFTPC associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display respiratory abnormalities similar to emphysema.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022097 Ensembl Gene Model | MGI Sequence Detail 3133 C57BL/6J ±  kb
    transcript ENSMUST00000022692 Ensembl | MGI Sequence Detail 792 Not Applicable  
    polypeptide ENSMUSP00000022692 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      57 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007084 BRICHOS domain
      IPR001729 Pulmonary surfactant-associated protein C
      IPR018051 Surfactant-associated polypeptide, palmitoylation site
      IPR015091 Surfactant protein C, N-terminal propeptide
    Molecular
    Reagents
    less
    • All nucleic 932
      Genomic 1
      cDNA 908
      Primer pair 14
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14378, MGD-MRK-14381, MGD-MRK-39516
    References
    more
    • Summaries
      All 353
      Developmental Gene Expression 284
      Diseases 1
      Gene Ontology 5
      Phenotypes 39
    • Earliest
      J:10878 Glasser SW, et al., Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem. 1990 Dec 15;265(35):21986-91
    • Latest
      J:261368 Jin H, et al., Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L882-L892

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory