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Sftpc
Gene Detail
 Symbol
Name
ID
Sftpc
surfactant associated protein C
MGI:109517
STS D14Mit32, D14Mit33
Synonyms Bricd6, pro-SpC, Sftp2, Sftp-2, SPC, SP-C
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:70520941-70524081 bp, - strand
From NCBI annotation of GRCm38

  3141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: pulmonary surfactant protein C
Gene Tree: Sftpc

Human
homologs
Human Homolog SFTPC, surfactant protein C
NCBI Gene ID 6440
neXtProt AC  NX_P11686
Human Synonyms  BRICD6, PSP-C, SFTP2, SMDP2, SP-C
Human Chr (Location)  8p21; chr8:22158721-22164479 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SFTPC
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display respiratory abnormalities similar to emphysema.
 
Human Diseases Modeled Using Mouse Sftpc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(6)
Interactions
Sftpc interacts with 30 markers (Mir153, Mir181d, Mir302c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process protein homooligomerization
Component alveolar lamellar body, cytoplasm, ...
Function protein homodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (204 records)
Data Summary: Results (178)    Tissues (44)    Images (70)
Theiler Stages: 14, 15, 16, 18, 19, 21, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 35
RNA in situ 49
Northern blot 24
Western blot 28
RT-PCR 36
Nuclease S1 6
cDNA source data(903)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(925) Genomic(1) cDNA(908) Primer pair(9) Other(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022097 (Evidence)
Entrez Gene20389 (Evidence)
UniGene24040
DFCITC1573873
DoTSDT.101406767, DT.101406775
NIA Mouse Gene IndexU035749
Consensus CDS ProjectCCDS27254.1
International Mouse Knockout Project StatusSftpc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20389 NCBI Gene Model | MGI Sequence Detail 3141 C57BL/6J ±  kb
transcript NM_011359 RefSeq | MGI Sequence Detail 804 C57BL/6 
polypeptide NP_035489 RefSeq | MGI Sequence Detail 193 C57BL/6 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007084 BRICHOS domain
InterPro IPR001729 Surfactant-associated polypeptide
InterPro IPR018051 Surfactant-associated polypeptide, palmitoylation site
InterPro IPR015091 Surfactant protein C, N-terminal propeptide
Protein Ontology PR:000014774 pulmonary surfactant-associated protein C
References (Earliest) J:10878 Glasser SW, et al., Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem. 1990 Dec 15;265(35):21986-91
(Latest) J:211356 Watanabe-Takano H, et al., DA-Raf-dependent inhibition of the Ras-ERK signaling pathway in type 2 alveolar epithelial cells controls alveolar formation. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2291-300
All references(247)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14378, MGD-MRK-14381, MGD-MRK-39516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory