Sftpc
Gene Detail

Symbol Name ID

Sftpc surfactant associated protein C MGI:109517

STS

D14Mit32, D14Mit33

Synonyms

Bricd6, pro-SpC, Sftp2, Sftp-2, SP-C

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:70520941-70524081 bp, - strand From NCBI annotation of GRCm38   3141 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: pulmonary surfactant protein C
Gene Tree: Sftpc

Human homologs

Human Homolog		SFTPC, surfactant protein C
NCBI Gene ID		6440
neXtProt AC		NX_P11686
Human Synonyms		BRICD6, PSP-C, SFTP2, SMDP2, SP-C
Human Chr (Location)		8p21; chr8:22019184-22021992 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SFTPC

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene display respiratory abnormalities similar to emphysema.

 
Human Diseases Modeled Using Mouse Sftpc (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	protein homooligomerization
Component	alveolar lamellar body, cytoplasm, ...
Function	protein homodimerization activity

External Resources: FuncBase

Expression

Literature Summary: (182 records)
Data Summary: Results (151)    Tissues (39)    Images (57)
Theiler Stages: 14, 15, 16, 18, 19, 21, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	48
Northern blot	20
Western blot	28
RT-PCR	26
Nuclease S1	6

cDNA source data(902)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(919) Genomic(1) cDNA(907) Primer pair(5) Other(6)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022097 (Evidence)
Entrez Gene	20389 (Evidence)
UniGene	24040
DFCI	TC1573873
DoTS	DT.101406767, DT.101406775
NIA Mouse Gene Index	U035749
Consensus CDS Project	CCDS27254.1
International Mouse Knockout Project Status	Sftpc

Sequences

Length	Strain/Species
genomic	20389	NCBI Gene Model | MGI Sequence Detail	3141	C57BL/6J
transcript	NM_011359	RefSeq | MGI Sequence Detail	804	C57BL/6
polypeptide	NP_035489	RefSeq | MGI Sequence Detail	193	C57BL/6

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007084	BRICHOS domain
InterPro	IPR001729	Surfactant-associated polypeptide
InterPro	IPR018051	Surfactant-associated polypeptide, palmitoylation site
InterPro	IPR015091	Surfactant protein C, N-terminal propeptide
Protein Ontology	PR:000014774	pulmonary surfactant-associated protein C

References

(Earliest) J:10878 Glasser SW, et al., Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse. J Biol Chem. 1990 Dec 15;265(35):21986-91
(Latest) J:192804 Yates LL, et al., Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol. 2013 Jan 15;373(2):267-80
All references(220)

Other accession IDs

MGD-MRK-14378, MGD-MRK-14381, MGD-MRK-39516