Tfam
Gene Detail

Symbol Name ID

Tfam transcription factor A, mitochondrial MGI:107810

Synonyms

Hmgts, mtTFA, tsHMG

Feature Type

protein coding gene

Genetic Map

Chromosome 10

36.83 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr10:71225464-71238280 bp, - strand From VEGA annotation of GRCm38   12817 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tfam

Human homologs

Human Homolog		TFAM, transcription factor A, mitochondrial
NCBI Gene ID		7019
neXtProt AC		NX_Q00059
Human Synonyms		MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3
Human Chr (Location)		10q21; chr10:60144903-60158990 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

Homozygous null mutants exhibit retarded growth, abnormal somite development, lack of optic discs, cardiac defects and delayed neural development. Mutants die by embryonic day 10.5.

 
Human Diseases Modeled Using Mouse Tfam (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	mitochondrial respiratory chain complex assembly, positive regulation of transcription, DNA-dependent, ...
Component	mitochondrial nucleoid, mitochondrion, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (166)    Tissues (82)    Images (33)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 21, 23, 25, 26, 28

Assay Type	Results
RNA in situ	136
Northern blot	6
RT-PCR	24

cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(139) Genomic(9) cDNA(127) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031039 (Evidence)
Ensembl Gene Model	ENSMUSG00000003923 (Evidence)
Entrez Gene	21780 (Evidence)
UniGene	229292
DFCI	TC1573066, TC1595177, TC1598773
DoTS	DT.101378580, DT.110591065, DT.534131
NIA Mouse Gene Index	U031911
Consensus CDS Project	CCDS23916.1
International Mouse Knockout Project Status	Tfam

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031039	VEGA Gene Model | MGI Sequence Detail	12817	C57BL/6J
transcript	OTTMUST00000076898	VEGA | MGI Sequence Detail	4167	Not Applicable
polypeptide	OTTMUSP00000040542	VEGA | MGI Sequence Detail	243	Not Applicable

All sequences(75) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
Protein Ontology	PR:000016262	transcription factor A, mitochondrial

References

(Earliest) J:34089 Parisi MA, et al., Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science. 1991 May 17;252(5008):965-9
(Latest) J:194082 Vernochet C, et al., Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metab. 2012 Dec 5;16(6):765-76
All references(93)

Other accession IDs

MGD-MRK-29055, MGD-MRK-36387, MGI:2143662