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Tfam
Gene Detail
Symbol

Name
ID
Tfam
transcription factor A, mitochondrial
MGI:107810
Synonyms
Hmgts, mtTFA, tsHMG
Feature Type
protein coding gene
Genetic Map
Chromosome 10
36.83 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr10:71225464-71238280 bp, - strand
From VEGA annotation of GRCm38

  12817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFAM
Gene Tree: Tfam

Human
homologs
TFAM, transcription factor A, mitochondrial
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7019
neXtProt AC: NX_Q00059

Human Synonyms: MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3

Human Chr (Location): 10q21; chr10:58385143-58399230 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mutants exhibit retarded growth, abnormal somite development, lack of optic discs, cardiac defects and delayed neural development. Mutants die by embryonic day 10.5.
 
Human Diseases Modeled in Mice Using Tfam (2)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Tfam interacts with 360 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process chromatin remodeling, mitochondrial respiratory chain complex assembly, ...
Component mitochondrial nucleoid, mitochondrion, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (155)    Tissues (78)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
Northern blot 6
RT-PCR 13
cDNA source data(127)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tfam ; ZFIN tfam    NEW 
Molecular
reagents
All nucleic(139) Genomic(9) cDNA(127) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031039 (Evidence)
Ensembl Gene Model ENSMUSG00000003923 (Evidence)
Entrez Gene 21780 (Evidence)
UniGene 229292
DFCI TC1598773, TC1595177, TC1573066
DoTS DT.101378580, DT.534131, DT.110591065
NIA Mouse Gene Index U031911
Consensus CDS Project CCDS23916.1
International Mouse Phenotyping Consortium Status Tfam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031039 VEGA Gene Model | MGI Sequence Detail 12817 C57BL/6J ±  kb
transcript OTTMUST00000076898 VEGA | MGI Sequence Detail 4167 Not Applicable 
polypeptide OTTMUSP00000040542 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000016262 transcription factor A, mitochondrial
References
(Earliest) J:12755 Boissonneault G, et al., A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids. Mol Cell Biol. 1993 Jul;13(7):4323-30
(Latest) J:218614 Kloepper JE, et al., Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions. J Invest Dermatol. 2015 Mar;135(3):679-89
All references(103)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-29055, MGD-MRK-36387, MGI:2143662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory