About   Help   FAQ
Tfam
Gene Detail
Symbol

Name
ID
Tfam
transcription factor A, mitochondrial
MGI:107810
Synonyms
Hmgts, mtTFA, tsHMG
Feature Type
protein coding gene
Genetic Map
Chromosome 10
36.83 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr10:71225464-71238280 bp, - strand
From VEGA annotation of GRCm38

  12817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tfam

Human
homologs
Human Homolog TFAM, transcription factor A, mitochondrial
NCBI Gene ID 7019
neXtProt AC  NX_Q00059
Human Synonyms  MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3
Human Chr (Location)  10q21; chr10:58385143-58399230 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mutants exhibit retarded growth, abnormal somite development, lack of optic discs, cardiac defects and delayed neural development. Mutants die by embryonic day 10.5.
 
Human Diseases Modeled Using Mouse Tfam (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Tfam interacts with 360 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process chromatin remodeling, mitochondrial respiratory chain complex assembly, ...
Component mitochondrial nucleoid, mitochondrion, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (155)    Tissues (78)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
Northern blot 6
RT-PCR 13
cDNA source data(127)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) Genomic(9) cDNA(127) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031039 (Evidence)
Ensembl Gene ModelENSMUSG00000003923 (Evidence)
Entrez Gene21780 (Evidence)
UniGene229292
DFCITC1595177, TC1573066, TC1598773
DoTSDT.534131, DT.110591065, DT.101378580
NIA Mouse Gene IndexU031911
Consensus CDS ProjectCCDS23916.1
International Mouse Knockout Project StatusTfam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031039 VEGA Gene Model | MGI Sequence Detail 12817 C57BL/6J ±  kb
transcript OTTMUST00000076898 VEGA | MGI Sequence Detail 4167 Not Applicable 
polypeptide OTTMUSP00000040542 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
Protein Ontology PR:000016262 transcription factor A, mitochondrial
References
(Earliest) J:34089 Parisi MA, et al., Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science. 1991 May 17;252(5008):965-9
(Latest) J:213840 Hamanaka RB, et al., Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal. 2013 Feb 5;6(261):ra8
All references(102)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-29055, MGD-MRK-36387, MGI:2143662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory