70 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cnptm1(cre)Kan/Cnp+ Tfamtm1Lrsn/Tfamtm1Lrsn involves: 129S1/Sv * 129X1/SvJ	abnormal colon morphology	J:228933
	abnormal enteric neuron morphology	J:228933
	abnormal PNS glial cell morphology	J:228933
	abnormal small intestine morphology	J:228933
	axon degeneration	J:228933
	decreased body size	J:228933
	decreased mitochondrial DNA content	J:228933
	decreased neuron mitochondrial DNA content	J:228933
	decreased neuron number	J:228933
	distended abdomen	J:228933
	neurodegeneration	J:228933
	postnatal growth retardation	J:228933
	premature death	J:228933
Myl1tm1(cre)Sjb/Myl1+ Tfamtm1Lrsn/Tfamtm1Lrsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal respiratory electron transport chain	J:81561
	bradykinesia	J:81561
	impaired skeletal muscle contractility	J:81561
	increased skeletal muscle fiber size	J:81561
	premature death	J:81561
	weight loss	J:81561
Slc6a3tm1(cre)Lrsn/Slc6a3+ Tfamtm1Lrsn/Tfamtm1Lrsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal dopaminergic neuron morphology	J:119515
	abnormal limb posture	J:119515
	decreased dopamine level	J:119515
	decreased exploration in new environment	J:119515
	decreased locomotor activity	J:119515
	loss of dopaminergic neurons	J:119515
	muscle spasm	J:119515
	neuronal intranuclear inclusions	J:119515
	premature death	J:119515
	tremors	J:119515
Tfamtm1.1Lrsn/Tfamtm1.1Lrsn involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal heart development	J:46387
	abnormal mitochondrial ATP synthesis coupled electron transport	J:125471
	abnormal nervous system physiology	J:46387
	abnormal somite development	J:46387
	absent optic nerve	J:46387
	decreased body size	J:46387
	decreased mitochondrial DNA content	J:46387
	disorganized mitochondrial cristae	J:46387
	embryonic lethality during organogenesis, complete penetrance	J:46387
	increased apoptosis	J:125471
	increased mitochondrial size	J:46387
Tfamtm1.1Ncdl/Tfamtm1.1Ncdl Tg(KRT14-cre)1Amc/0 involves: C57BL/6 * CBA	abnormal hair cycle catagen phase	J:213840
	abnormal keratinocyte differentiation	J:213840
	abnormal keratinocyte physiology	J:213840
	abnormal mitochondrial physiology	J:213840
	abnormal redox activity	J:213840
	absent sebaceous gland	J:213840
	decreased hair follicle number	J:213840
	decreased subcutaneous adipose tissue amount	J:213840
	increased keratinocyte proliferation	J:213840
	premature death	J:213840
	progressive hair loss	J:213840
	slow postnatal weight gain	J:213840
	thick epidermis	J:213840
Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Camk2a-cre)1Lfr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal respiratory electron transport chain	J:72037
	axon degeneration	J:72037
	gliosis	J:72037
	neurodegeneration	J:72037
	neuron degeneration	J:72037
	premature death	J:72037
Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Ckmm-cre)1Lrsn/0 involves: 129S1/Sv * 129X1/SvJ	abnormal blood flow velocity	J:51964
	abnormal cardiovascular system physiology	J:51964
	abnormal enzyme/coenzyme level	J:125471
	abnormal respiratory electron transport chain	J:125471
	bradykinesia	J:51964
	dilated cardiomyopathy	J:51964
	dilated heart left ventricle	J:51964
	enlarged heart	J:51964
	increased cardiomyocyte apoptosis	J:125471
	increased glutathione peroxidase activity	J:125471
	increased heart weight	J:51964
	increased physiological sensitivity to xenobiotic	J:51964
	postnatal growth retardation	J:51964
	postnatal lethality, complete penetrance	J:51964
Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Ins2-cre)25Mgn/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	abnormal circulating insulin level	J:65522
	abnormal mitochondrial morphology	J:65522
	abnormal respiratory electron transport chain	J:65522
	absent pancreatic beta cells	J:65522
	decreased insulin secretion	J:65522
	decreased mitochondrial DNA content	J:65522
	increased insulin sensitivity	J:65522
Tfamtm1Lrsn/Tfamtm1Lrsn Tg(Myhca-cre)1Lrsn/0 involves: 129S1/Sv * 129X1/SvJ * FVB	abnormal respiratory electron transport chain	J:61372
	dilated heart atrium	J:61372
	dilated heart left ventricle	J:61372
	dilated heart right ventricle	J:61372
	increased heart weight	J:61372
	neonatal lethality, incomplete penetrance	J:61372
	premature death	J:61372
Tg(Prm1-Tfam)4Lrsn/? involves: FVB/N	normal cellular phenotype	J:95207