Symbol
Name
ID

Tfam
transcription factor A, mitochondrial
MGI:107810

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Hypertyrosinemia

Hypermethioninemia

Hyperbilirubinemia

Conjugated hyperbilirubinemia

Hypoalbuminemia

Elevated circulating hepatic transaminase concentration

Elevated circulating alkaline phosphatase concentration

Hypoglycemia

Microvesicular hepatic steatosis

4-hydroxyphenylacetic aciduria

4-Hydroxyphenylpyruvic aciduria

Ascites

Disease(s) Associated with TFAM

mitochondrial DNA depletion syndrome 15

Mouse Phenotypes		decreased insulin secretion	abnormal circulating insulin level	decreased dopamine level	abnormal enzyme/coenzyme level	increased insulin sensitivity	increased glutathione peroxidase activity	increased physiological sensitivity to xenobiotic
Availability	Mouse Genotype	decreased insulin secretion	abnormal circulating insulin level	decreased dopamine level	abnormal enzyme/coenzyme level	increased insulin sensitivity	increased glutathione peroxidase activity	increased physiological sensitivity to xenobiotic
	Tfam^tm1Lrsn/Tfam^tm1Lrsn Tg(Ckmm-cre)1Lrsn/0 (conditional)
	Tfam^tm1Lrsn/Tfam^tm1Lrsn Tg(Ins2-cre)25Mgn/0 (conditional)
	Slc6a3^tm1(cre)Lrsn/Slc6a3⁺ Tfam^tm1Lrsn/Tfam^tm1Lrsn (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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