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Rbfox3 Gene Detail
Summary
  • Symbol
    Rbfox3
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 3
  • Synonyms
    D11Bwg0517e, Hrnbp3, NeuN, Neuna60
  • Feature Type
    protein coding gene
  • IDs
    MGI:106368
    NCBI Gene: 52897
Location & Maps
more
  • Sequence Map
    Chr11:118489762-118911597 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      421836 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.22 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RBFOX3, RNA binding protein, fox-1 homolog 3
  • Vertebrate Orthologs
    4
  • Human Ortholog
    RBFOX3, RNA binding protein, fox-1 homolog 3
    Orthology source: HGNC
  • Synonyms
    FOX3, FOX-3, HRNBP3, NEUN
  • Links
    NCBI Gene ID: 146713
    neXtProt AC: NX_A6NFN3

  • Chr Location
    17q25.3; chr17:79089345-79611101 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003975 VEGA Gene Model | MGI Sequence Detail 421836 C57BL/6J ±  kb
transcript OTTMUST00000008832 VEGA | MGI Sequence Detail 3150 Not Applicable  
polypeptide OTTMUSP00000004303 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1702 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006252 RNA binding protein fox-1 homolog 3
  • InterPro Domains
    IPR025670 Fox-1 C-terminal domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR017325 RNA binding protein Fox-1
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-34061, MGI:1929613
References
more
  • Summaries
    All 531
    Developmental Gene Expression 480
    Gene Ontology 23
    Phenotypes 4
  • Earliest
    J:31592 Mullen RJ, et al., NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992 Sep;116(1):201-11
  • Latest
    J:231951 Nakamura A, et al., Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors. J Neurosci. 2016 May 18;36(20):5448-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory