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Rbfox3 Gene Detail
Summary
  • Symbol
    Rbfox3
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 3
  • Synonyms
    D11Bwg0517e, Hrnbp3, NeuN, Neuna60
  • Feature Type
    protein coding gene
  • IDs
    MGI:106368
    NCBI Gene: 52897
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:118489762-118911597 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      421836 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.22 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RBFOX3, RNA binding fox-1 homolog 3
  • Vertebrate Orthologs
    4
  • Human Ortholog
    RBFOX3, RNA binding fox-1 homolog 3
    Orthology source: HGNC
  • Synonyms
    FOX3, FOX-3, HRNBP3, NEUN
  • Links
    NCBI Gene ID: 146713
    neXtProt AC: NX_A6NFN3
    UniProt: A6NFN3

  • Chr Location
    17q25.3; chr17:79089345-79611101 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced brain weight, increased susceptibility kainic acid-induced seizures, decreased anxiety-related behaviors, and deficits in synaptic transmission and plasticity in the dentate gyrus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003975 VEGA Gene Model | MGI Sequence Detail 421836 C57BL/6J ±  kb
    transcript OTTMUST00000008832 VEGA | MGI Sequence Detail 3150 Not Applicable  
    polypeptide OTTMUSP00000004303 VEGA | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1702 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 24
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34061, MGI:1929613
    References
    more
    • Summaries
      All 642
      Developmental Gene Expression 585
      Gene Ontology 23
      Phenotypes 7
    • Earliest
      J:31592 Mullen RJ, et al., NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992 Sep;116(1):201-11
    • Latest
      J:260444 Hayashi M, et al., Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control. Neuron. 2018 Feb 21;97(4):869-884.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/19/2018
    MGI 6.12
    The Jackson Laboratory