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Rbfox3 Gene Detail
Summary
  • Symbol
    Rbfox3
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 3
  • Synonyms
    D11Bwg0517e, Hrnbp3, NeuN, Neuna60
  • Feature Type
    protein coding gene
  • IDs
    MGI:106368
    NCBI Gene: 52897
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118489762-118911597 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1702 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106368
protein coding gene Chr11:118489760-118911597 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019470
protein coding gene Chr11:122814789-123253315 (-)
A/J MGP_AJ_G0019438
protein coding gene Chr11:117377110-117804474 (-)
AKR/J MGP_AKRJ_G0019408
protein coding gene Chr11:120935566-121364193 (-)
BALB/cJ MGP_BALBcJ_G0019413
protein coding gene Chr11:117738624-118165077 (-)
C3H/HeJ MGP_C3HHeJ_G0019219
protein coding gene Chr11:121243515-121674703 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019862
protein coding gene Chr11:126577557-127017805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017487
protein coding gene Chr11:114375468-114802892 (-)
CAST/EiJ MGP_CASTEiJ_G0018773
protein coding gene Chr11:122669842-123108097 (-)
CBA/J MGP_CBAJ_G0019190
protein coding gene Chr11:131491707-131946552 (-)
DBA/2J MGP_DBA2J_G0019302
protein coding gene Chr11:116757726-117182838 (-)
FVB/NJ MGP_FVBNJ_G0019294
protein coding gene Chr11:116406651-116839959 (-)
LP/J MGP_LPJ_G0019372
protein coding gene Chr11:123137534-123571955 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019327
protein coding gene Chr11:130484320-130923495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019901
protein coding gene Chr11:121598875-122029223 (-)
PWK/PhJ MGP_PWKPhJ_G0018539
protein coding gene Chr11:118146301-118575995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018331
protein coding gene Chr11:121318425-121768900 (-)
WSB/EiJ MGP_WSBEiJ_G0018825
protein coding gene Chr11:121554750-121993946 (-)



Homology
more
  • Human Ortholog
    RBFOX3, RNA binding fox-1 homolog 3
  • Vertebrate Orthologs
    4
  • Human Ortholog
    RBFOX3, RNA binding fox-1 homolog 3
    Orthology source: HGNC
  • Synonyms
    FOX3, FOX-3, HRNBP3, NEUN
  • Links
    NCBI Gene ID: 146713
    neXtProt AC: NX_A6NFN3
    UniProt: A6NFN3

  • Chr Location
    17q25.3; chr17:79089345-79611101 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced brain weight, increased susceptibility kainic acid-induced seizures, decreased anxiety-related behaviors, and deficits in synaptic transmission and plasticity in the dentate gyrus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025576 Ensembl Gene Model | MGI Sequence Detail 421836 C57BL/6J ±  kb
    transcript ENSMUST00000017576 Ensembl | MGI Sequence Detail 3150 Not Applicable  
    polypeptide ENSMUSP00000017576 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34061, MGI:1929613
    References
    more
    • Summaries
      All 700
      Developmental Gene Expression 639
      Gene Ontology 24
      Phenotypes 7
    • Earliest
      J:31592 Mullen RJ, et al., NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992 Sep;116(1):201-11
    • Latest
      J:276133 Yang CY, et al., Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation. J Neurosci. 2019 Jun 19;39(25):4959-4975

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory