Rbfox3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rbfox3
RNA binding protein, fox-1 homolog (C. elegans) 3
MGI:106368

30 phenotypes from 1 allele in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rbfox3^{tm1a(EUCOMM)Hmgu}/Rbfox3^{tm1a(EUCOMM)Hmgu} B6Dnk;B6N-Rbfox3^{tm1a(EUCOMM)Hmgu}/H	abnormal brain white matter morphology	J:234043
	abnormal CNS synaptic transmission	J:234043
	abnormal dentate gyrus neuron dendrite morphology	J:234043
	abnormal excitatory postsynaptic potential	J:234043, J:240501
	abnormal excitatory synapse morphology	J:240501
	abnormal hippocampus granule cell morphology	J:234043
	abnormal hippocampus neuron morphology	J:234043
	abnormal hippocampus physiology	J:234043
	abnormal miniature inhibitory postsynaptic currents	J:234043
	abnormal neuron differentiation	J:240501
	abnormal object recognition memory	J:240501
	abnormal thermal nociception	J:240501
	normal behavior/neurological phenotype	J:240501
	decreased anxiety-related response	J:234043
	decreased brain weight	J:234043
	decreased neuronal precursor cell number	J:240501
	decreased neuronal precursor proliferation	J:240501
	decreased paired-pulse facilitation	J:234043
	impaired spatial learning	J:234043
	impaired synaptic plasticity	J:234043, J:240501
	increased dendritic spine density	J:234043
	increased locomotor activity	J:234043
	increased miniature inhibitory postsynaptic current frequency	J:234043
	increased neurotransmitter release	J:234043
	increased susceptibility to pharmacologically induced seizures	J:234043
	increased susceptibility to xenobiotic induced morbidity/mortality	J:234043
	normal nervous system phenotype	J:234043, J:240501
	reduced long-term depression	J:234043, J:240501
Rbfox3^{tm1a(EUCOMM)Hmgu}/Rbfox3^{tm1a(EUCOMM)Hmgu} Not Specified	decreased circulating alkaline phosphatase level	J:165965
	decreased grip strength	J:165965

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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