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Cdc42
Gene Detail
 Symbol
Name
ID
Cdc42
cell division cycle 42
MGI:106211
Feature Type protein coding gene
Genetic Map
Chromosome 4
69.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:137319696-137357720 bp, - strand
From VEGA annotation of GRCm38

  38025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Cdc42

Human
homologs
Human Homolog CDC42, cell division cycle 42
NCBI Gene ID 998
neXtProt AC  NX_P60953
Human Synonyms  CDC42Hs, G25K
Human Chr (Location)  1p36.1; chr1:22052627-22092943 (+)  GRCh38
Alleles
and
phenotypes
All alleles(82) : Targeted(9) Gene trapped(73)
 
Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.
 
Human Diseases Modeled Using Mouse Cdc42 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (111 annotations)
Process actin cytoskeleton organization, actin filament branching, ...
Component apical part of cell, cell, ...
Function apolipoprotein A-I receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (174)    Tissues (118)    Images (26)
Theiler Stages: 2, 3, 4, 5, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 88
Western blot 19
RT-PCR 58
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000009829 (Evidence)
Ensembl Gene ModelENSMUSG00000006699 (Evidence)
Entrez Gene12540 (Evidence)
NIA Mouse Gene IndexU025678, U112227
PDB3EG5
Consensus CDS ProjectCCDS18816.1, CCDS57305.1
International Mouse Knockout Project StatusCdc42
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009829 VEGA Gene Model | MGI Sequence Detail 38025 C57BL/6J ±  kb
transcript OTTMUST00000022761 VEGA | MGI Sequence Detail 2108 Not Applicable 
polypeptide OTTMUSP00000010388 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000005204 cell division control protein 42
References (Earliest) J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39:279-84
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(200)
Other
accession IDs
MGD-MRK-33903, MGI:2140354, MGI:2140443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory