Cdc42
Gene Detail

Symbol Name ID

Cdc42 cell division cycle 42 MGI:106211

Feature Type

protein coding gene

Genetic Map

Chromosome 4

69.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr4:137319696-137357720 bp, - strand From VEGA annotation of GRCm38   38025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:123986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Cdc42

Human homologs

Human Homolog		CDC42, cell division cycle 42
NCBI Gene ID		998
neXtProt AC		NX_P60953
Human Synonyms		CDC42Hs, G25K
Human Chr (Location)		1p36.1; chr1:22379120-22419436 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(81) : Targeted(8) Gene trapped(73)
 

Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.

 
Human Diseases Modeled Using Mouse Cdc42 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (108 annotations)

Process	actin cytoskeleton organization, actin filament branching, ...
Component	apical part of cell, cell periphery, ...
Function	apolipoprotein A-I receptor binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (47 records)
Data Summary: Results (173)    Tissues (118)    Images (25)
Theiler Stages: 2, 3, 4, 5, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	88
Western blot	19
RT-PCR	58

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000009829 (Evidence)
Ensembl Gene Model	ENSMUSG00000006699 (Evidence)
Entrez Gene	12540 (Evidence)
NIA Mouse Gene Index	U025678, U112227
PDB	3EG5
Consensus CDS Project	CCDS18816.1, CCDS57305.1
International Mouse Knockout Project Status	Cdc42

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009829	VEGA Gene Model | MGI Sequence Detail	38025	C57BL/6J
transcript	OTTMUST00000022761	VEGA | MGI Sequence Detail	2108	Not Applicable
polypeptide	OTTMUSP00000010388	VEGA | MGI Sequence Detail	191	Not Applicable

All sequences(70) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(91 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003578	Small GTPase superfamily, Rho type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000005204	cell division control protein 42

References

(Earliest) J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39:279-84
(Latest) J:195797 Heynen SR, et al., CDC42 is required for tissue lamination and cell survival in the mouse retina. PLoS One. 2013;8(1):e53806
All references(182)

Other accession IDs

MGD-MRK-33903, MGI:2140354, MGI:2140443