About   Help   FAQ
Cdc42
Gene Detail
 Symbol
Name
ID
Cdc42
cell division cycle 42
MGI:106211
Feature Type protein coding gene
Genetic Map
Chromosome 4
69.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:137319696-137357720 bp, - strand
From VEGA annotation of GRCm38

  38025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137230  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Cdc42

Mutations,
alleles, and
phenotypes
All mutations/alleles(82) : Gene trapped(73) Targeted(9)
 
Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.
 
Human Diseases Modeled Using Mouse Cdc42 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Cdc42 interacts with 284 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (94 annotations)
Process actin filament branching, actin filament bundle assembly, ...
Component apical part of cell, cell, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (168)    Tissues (115)    Images (26)
Theiler Stages: 2, 3, 4, 5, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 88
Western blot 19
RT-PCR 52
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(51) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000009829 (Evidence)
Ensembl Gene ModelENSMUSG00000006699 (Evidence)
Entrez Gene12540 (Evidence)
NIA Mouse Gene IndexU025678, U112227
PDB3EG5
Consensus CDS ProjectCCDS18816.1, CCDS57305.1
International Mouse Knockout Project StatusCdc42
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009829 VEGA Gene Model | MGI Sequence Detail 38025 C57BL/6J ±  kb
transcript OTTMUST00000022762 VEGA | MGI Sequence Detail 1448 Not Applicable 
polypeptide OTTMUSP00000010389 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000005204 cell division control protein 42
References (Earliest) J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39:279-84
(Latest) J:208799 Afshordel S, et al., Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain. J Neurochem. 2014 May;129(4):732-42
All references(206)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33903, MGI:2140354, MGI:2140443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory