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Cdc42 Gene Detail
Summary
  • Symbol
    Cdc42
  • Name
    cell division cycle 42
  • Feature Type
    protein coding gene
  • IDs
    MGI:106211
    NCBI Gene: 12540
Location & Maps
more
  • Sequence Map
    Chr4:137319696-137357720 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38025 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.83 cM
  • Mapping Data
    9 experiments
Homology
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Human Diseases
more
  • Diseases
    2 with Cdc42 mouse models

Human Disease Mouse Models
       Diarrhea 2, with Microvillus Atrophy; DIAR2   OMIM: 251850 View 1 model
Takenouchi-Kosaki Syndrome; TKS   OMIM: 616737 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    114 phenotypes from 7 alleles in 12 genetic backgrounds
    16 phenotypes from multigenic genotypes
    2 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    86
  • Chemically induced (other)
    2
  • Gene trapped
    73
  • Targeted
    11
  • Genomic Mutations
    3 involving Cdc42
Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009829 VEGA Gene Model | MGI Sequence Detail 38025 C57BL/6J ±  kb
transcript OTTMUST00000022761 VEGA | MGI Sequence Detail 2108 Not Applicable  
polypeptide OTTMUSP00000010388 VEGA | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    255 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005204 cell division control protein 42
  • PDB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 55
    Genomic 1
    cDNA 51
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-33903, MGI:2140354, MGI:2140443
References
more
  • Summaries
    All 233
    Developmental Gene Expression 62
    Diseases 2
    Gene Ontology 40
    Phenotypes 77
  • Earliest
    J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39:279-84
  • Latest
    J:233715 Druso JE, et al., An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland. J Biol Chem. 2016 Apr 22;291(17):8886-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory