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Cdc42 Gene Detail
Summary
  • Symbol
    Cdc42
  • Name
    cell division cycle 42
  • Feature Type
    protein coding gene
  • IDs
    MGI:106211
    NCBI Gene: 12540
  • Gene Overview
    MyGene.info: CDC42
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:137319696-137357720 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38025 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.83 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    CDC42, cell division cycle 42
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CDC42, cell division cycle 42
    Orthology source: HGNC
  • Synonyms
    CDC42Hs, G25K, TKS
  • Links
    NCBI Gene ID: 998
    neXtProt AC: NX_P60953
    UniProt: P60953

  • Chr Location
    1p36.12; chr1:22052627-22092943 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cdc42 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    114 phenotypes from 7 alleles in 12 genetic backgrounds
    18 phenotypes from multigenic genotypes
    2 images
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are small, lack primary ectoderm, exhibit disorganized embryonic tissue and die before somite formation. Mice homozygous for a gene trapped allele die at E3.5-E7.5. Mice heterozygous for a targeted allele show reduced ventricle muscle contractility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009829 VEGA Gene Model | MGI Sequence Detail 38025 C57BL/6J ±  kb
    transcript OTTMUST00000022761 VEGA | MGI Sequence Detail 2108 Not Applicable  
    polypeptide OTTMUSP00000010388 VEGA | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      255 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 52
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33903, MGI:2140354, MGI:2140443
    References
    more
    • Summaries
      All 307
      Developmental Gene Expression 69
      Diseases 1
      Gene Ontology 45
      Phenotypes 92
    • Earliest
      J:5848 Johnson DR, Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse. J Embryol Exp Morphol. 1977 Jun;39:279-84
    • Latest
      J:264110 Lavina B, et al., Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations. Development. 2018 Jul 2;145(13)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory