About   Help   FAQ
Dusp1
Gene Detail
 Symbol
Name
ID
Dusp1
dual specificity phosphatase 1
MGI:105120
Synonyms 3CH134, erp, mkp-1, MKP1, Ptpn16
Feature Type protein coding gene
Genetic Map
Chromosome 17
13.28 cM, cytoband A2-C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:26505590-26508519 bp, - strand
From VEGA annotation of GRCm38

  2930 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dual specificity protein phosphatase (MAP kinase phosphatase)
Gene Tree: Dusp1

Human
homologs
Human Homolog DUSP1, dual specificity phosphatase 1
NCBI Gene ID 1843
neXtProt AC  NX_P28562
Human Synonyms  CL100, HVH1, MKP1, MKP-1, PTPN10
Human Chr (Location)  5q34; chr5:172768090-172771200 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(2) Targeted(3)
Genomic Mutations involving Dusp1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice were viable, fertile, and showed no apparent morphological defects.
 
Interactions
Dusp1 interacts with 154 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell cycle, dephosphorylation, ...
Component cytoplasm, nucleus
Function hydrolase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (223)    Tissues (142)    Images (55)
Theiler Stages: 19, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 217
RT-PCR 6
cDNA source data(86)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(90) Genomic(1) cDNA(86) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020083 (Evidence)
Ensembl Gene ModelENSMUSG00000024190 (Evidence)
Entrez Gene19252 (Evidence)
UniGene239041
DFCITC1574874
DoTSDT.110565107, DT.490733
NIA Mouse Gene IndexU037581
EC3.1.3.16, 3.1.3.48
Consensus CDS ProjectCCDS28552.1
International Mouse Knockout Project StatusDusp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020083 VEGA Gene Model | MGI Sequence Detail 2930 C57BL/6J ±  kb
transcript OTTMUST00000047766 VEGA | MGI Sequence Detail 1990 Not Applicable 
polypeptide OTTMUSP00000021701 VEGA | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020417 Atypical dual specificity phosphatase
InterPro IPR020420 Atypical dual specificity phosphatase, subfamily B
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR001763 Rhodanese-like domain
Protein Ontology PR:000006736 dual specificity protein phosphatase 1
References (Earliest) J:2300 Charles CH, et al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992 Jan;7(1):187-90
(Latest) J:203050 Negishi H, et al., Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19884-9
All references(105)
Other
accession IDs
MGD-MRK-32161, MGI:2147160

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory