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Prkar1a Gene Detail
Summary
  • Symbol
    Prkar1a
  • Name
    protein kinase, cAMP dependent regulatory, type I, alpha
  • Synonyms
    1300018C22Rik, RIalpha, Tse1, Tse-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104878
    NCBI Gene: 19084
  • Gene Overview
    MyGene.info: PRKAR1A
Location & Maps
more
  • Sequence Map
    Chr11:109649405-109669656 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20252 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 72.33 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
  • Links
    NCBI Gene ID: 5573
    neXtProt AC: NX_P10644

  • Chr Location
    17q24.2; chr17:68413623-68551316 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Prkar1a mouse models; 5 with human PRKAR1A associations

Human Disease Mouse Models
       Carney Complex, Type 1; CNC1   OMIM: 160980 View 4 models
Pigmented Nodular Adrenocortical Disease, Primary, 1; PPNAD1   OMIM: 610489 View 1 model
       Acrodysostosis 1 with or without Hormone Resistance; ACRDYS1   OMIM: 101800
Myxoma, Intracardiac   OMIM: 255960
Thyroid Cancer, Nonmedullary, 1; NMTC1   OMIM: 188550
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 5 alleles in 10 genetic backgrounds
    9 phenotypes from multigenic genotypes
    4 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    5
  • Targeted
    9
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003351 VEGA Gene Model | MGI Sequence Detail 20252 C57BL/6J ±  kb
transcript OTTMUST00000007044 VEGA | MGI Sequence Detail 3513 Not Applicable  
polypeptide OTTMUSP00000003354 VEGA | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    42 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013228 cAMP-dependent protein kinase type I-alpha regulatory subunit
  • InterPro Domains
    IPR012198 cAMP-dependent protein kinase regulatory subunit
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 33
    cDNA 31
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15266, MGD-MRK-15269, MGD-MRK-29031, MGI:1914726
References
more
  • Summaries
    All 101
    Developmental Gene Expression 14
    Diseases 7
    Gene Ontology 10
    Phenotypes 43
  • Earliest
    J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
  • Latest
    J:228307 Zhou T, et al., Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory