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Prkar1a Gene Detail
Summary
  • Symbol
    Prkar1a
  • Name
    protein kinase, cAMP dependent regulatory, type I, alpha
  • Synonyms
    1300018C22Rik, RIalpha, Tse1, Tse-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104878
    NCBI Gene: 19084
  • Gene Overview
    MyGene.info: PRKAR1A
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109540231-109560482 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 72.33 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104878
protein coding gene Chr11:109539849-109560489 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019337
protein coding gene Chr11:113224045-113244304 (+)
A/J MGP_AJ_G0019305
protein coding gene Chr11:108322282-108343277 (+)
AKR/J MGP_AKRJ_G0019274
protein coding gene Chr11:111580977-111603197 (+)
BALB/cJ MGP_BALBcJ_G0019279
protein coding gene Chr11:108754318-108774555 (+)
C3H/HeJ MGP_C3HHeJ_G0019088
protein coding gene Chr11:111876670-111896924 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019729
protein coding gene Chr11:116651040-116672394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017352
protein coding gene Chr11:105545365-105565812 (+)
CAST/EiJ MGP_CASTEiJ_G0018641
protein coding gene Chr11:113016131-113036361 (+)
CBA/J MGP_CBAJ_G0019057
protein coding gene Chr11:121468471-121489110 (+)
DBA/2J MGP_DBA2J_G0019169
protein coding gene Chr11:107801485-107822928 (+)
FVB/NJ MGP_FVBNJ_G0019160
protein coding gene Chr11:107288129-107308379 (+)
LP/J MGP_LPJ_G0019239
protein coding gene Chr11:113635846-113655735 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019191
protein coding gene Chr11:120607004-120629612 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019766
protein coding gene Chr11:112140437-112160693 (+)
PWK/PhJ MGP_PWKPhJ_G0018406
protein coding gene Chr11:108967931-108988895 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018198
protein coding gene Chr11:111924286-111944414 (+)
WSB/EiJ MGP_WSBEiJ_G0018693
protein coding gene Chr11:112063622-112083538 (+)



Homology
more
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
  • Synonyms
    ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
  • Links
    NCBI Gene ID: 5573
    neXtProt AC: NX_P10644
    UniProt: P10644

  • Chr Location
    17q24.2; chr17:68413623-68551316 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Prkar1a mouse models; 3 with human PRKAR1A associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 4 models
IDs
View 1 model
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    94 phenotypes from 6 alleles in 12 genetic backgrounds
    22 phenotypes from multigenic genotypes
    9 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020612 Ensembl Gene Model | MGI Sequence Detail 20252 C57BL/6J ±  kb
    transcript ENSMUST00000049527 Ensembl | MGI Sequence Detail 3359 Not Applicable  
    polypeptide ENSMUSP00000056500 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013228 cAMP-dependent protein kinase type I-alpha regulatory subunit
    • InterPro Domains
      IPR012198 cAMP-dependent protein kinase regulatory subunit
      IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 36
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15266, MGD-MRK-15269, MGD-MRK-29031, MGI:1914726
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 17
      Diseases 8
      Gene Ontology 16
      Phenotypes 69
    • Earliest
      J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
    • Latest
      J:307300 Liu Y, et al., Loss of PKA regulatory subunit 1alpha aggravates cardiomyocyte necrosis and myocardial ischemia/reperfusion injury. J Biol Chem. 2021 Jun 1;297(1):100850

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/14/2021
    MGI 6.17
    The Jackson Laboratory