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Prkar1a Gene Detail
Summary
  • Symbol
    Prkar1a
  • Name
    protein kinase, cAMP dependent regulatory, type I, alpha
  • Synonyms
    1300018C22Rik, RIalpha, Tse1, Tse-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104878
    NCBI Gene: 19084
  • Gene Overview
    MyGene.info: PRKAR1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:109649405-109669656 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20252 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 72.33 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
  • Links
    NCBI Gene ID: 5573
    neXtProt AC: NX_P10644
    UniProt: P10644

  • Chr Location
    17q24.2; chr17:68413623-68551316 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Prkar1a mouse models; 3 with human PRKAR1A associations

Human Disease Mouse Models
      
IDs
View 4 models
IDs
View 1 model
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    72 phenotypes from 5 alleles in 11 genetic backgrounds
    22 phenotypes from multigenic genotypes
    9 images
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003351 VEGA Gene Model | MGI Sequence Detail 20252 C57BL/6J ±  kb
    transcript OTTMUST00000007043 VEGA | MGI Sequence Detail 3359 Not Applicable  
    polypeptide OTTMUSP00000003353 VEGA | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      42 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013228 cAMP-dependent protein kinase type I-alpha regulatory subunit
    • InterPro Domains
      IPR012198 cAMP-dependent protein kinase regulatory subunit
      IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 34
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15266, MGD-MRK-15269, MGD-MRK-29031, MGI:1914726
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 16
      Diseases 7
      Gene Ontology 11
      Phenotypes 57
    • Earliest
      J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
    • Latest
      J:244906 Berthon A, et al., Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum Mol Genet. 2017 Sep 15;26(18):3495-3507

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory