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Prkar1a
Gene Detail
Symbol

Name
ID
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878
Synonyms
1300018C22Rik, RIalpha, Tse1, Tse-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
72.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:109649405-109669656 bp, + strand
From VEGA annotation of GRCm38

  20252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: cAMP-dependent protein kinase, regulatory subunit
Gene Tree: Prkar1a

Human
homologs
Human Homolog PRKAR1A, protein kinase, cAMP-dependent, regulatory, type I, alpha
NCBI Gene ID 5573
neXtProt AC  NX_P10644
Human Synonyms  ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
Human Chr (Location)  17q24.2; chr17:68511780-68551316 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human PRKAR1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(5) Targeted(8)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence.
 
Human Diseases Modeled Using Mouse Prkar1a (2)    Alleles Annotated to Human Diseases(4)    Phenotype Images(4)
Interactions
Prkar1a interacts with 279 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (73)    Tissues (25)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
Northern blot 4
cDNA source data(29)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(29) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003351 (Evidence)
Ensembl Gene ModelENSMUSG00000020612 (Evidence)
Entrez Gene19084 (Evidence)
DFCITC1573773
DoTSDT.94151093, DT.101181443, DT.101213189, DT.101244388, DT.101248214, DT.101405600, DT.94217353, DT.99866343
NIA Mouse Gene IndexU013499
Consensus CDS ProjectCCDS25583.1
International Mouse Knockout Project StatusPrkar1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003351 VEGA Gene Model | MGI Sequence Detail 20252 C57BL/6J ±  kb
transcript OTTMUST00000007044 VEGA | MGI Sequence Detail 3513 Not Applicable 
polypeptide OTTMUSP00000003354 VEGA | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(8) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR012198 cAMP-dependent protein kinase regulatory subunit
InterPro IPR003117 cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013228 cAMP-dependent protein kinase type I-alpha regulatory subunit
References
(Earliest) J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
(Latest) J:208122 Yang L, et al., Selective Expression of a Dominant-Negative Type Ialpha PKA Regulatory Subunit in Striatal Medium Spiny Neurons Impairs Gene Expression and Leads to Reduced Feeding and Locomotor Activity. J Neurosci. 2014 Apr 2;34(14):4896-904
All references(96)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-15266, MGD-MRK-15269, MGD-MRK-29031, MGI:1914726

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory