Prkar1a
Gene Detail

Symbol Name ID

Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha MGI:104878

Synonyms

1300018C22Rik, RIalpha, Tse1, Tse-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

72.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:109649405-109669656 bp, + strand From VEGA annotation of GRCm38   20252 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Prkar1a ± 2 cM)

Protein SuperFamily: cAMP-dependent protein kinase, regulatory subunit
Gene Tree: Prkar1a

Human ortholog

PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha NCBI Gene ID 5573
Human Synonyms: ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, TSE1
Human Chr17:66508110-66528911 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PRKAR1A (5)

Alleles and phenotypes

All alleles(13) : Targeted(8) Gene trapped(5)
 

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence.

 
Human Diseases Modeled Using Mouse Prkar1a (3)    Alleles Annotated to Human Diseases(4)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cardiac muscle cell proliferation, cell proliferation, ...
Component	cAMP-dependent protein kinase complex, cytoplasm, ...
Function	cAMP binding, cAMP-dependent protein kinase regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (73)    Tissues (25)    Images (21)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	69
Northern blot	4

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(29) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003351 (Evidence)
Ensembl Gene Model	ENSMUSG00000020612 (Evidence)
Entrez Gene	19084 (Evidence)
DFCI	TC1573773
DoTS	DT.101181443, DT.101213189, DT.101244388, DT.101248214, DT.101405600, DT.94151093, DT.94217353, DT.99866343
NIA Mouse Gene Index	U013499
Consensus CDS Project	CCDS25583.1
International Mouse Knockout Project Status	Prkar1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003351	VEGA Gene Model | MGI Sequence Detail	20252	C57BL/6J
transcript	OTTMUST00000007044	VEGA | MGI Sequence Detail	3513	Not Applicable
polypeptide	OTTMUSP00000003354	VEGA | MGI Sequence Detail	381	Not Applicable

All sequences(71) RefSeq(2) UniProt(8)

Polymorphisms

RFLP(1) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002373	cAMP/cGMP-dependent protein kinase
InterPro	IPR012198	cAMP-dependent protein kinase regulatory subunit
InterPro	IPR003117	cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000013228	cAMP-dependent protein kinase type I-alpha regulatory subunit

References

(Earliest) J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
(Latest) J:188520 Ilouz R, et al., Localization and quaternary structure of the PKA RIbeta holoenzyme. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12443-8
All references(88)

Other accession IDs

MGD-MRK-15266, MGD-MRK-15269, MGD-MRK-29031, MGI:1914726