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Targeted Allele Detail
Symbol: Prkar1atm1Gsm
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight
MGI ID: MGI:2183602
Gene: Prkar1a  Location: Chr11:109540231-109560482 bp, + strand  Genetic Position: Chr11, 72.33 cM
Alliance: Prkar1atm1Gsm page
Tumors in Prkar1atm1Gsm/Prkar1a+ mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:78010
Parent Cell Line:  REK2 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 3 was disrupted by the insertion of a neomycin selection cassette. The absence of endcoded protein in homozygous mutant mice was confirmed via Western blot analysis. (J:78010)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkar1a Mutation:  16 strains or lines available
Original:  J:78010 Amieux PS, et al., Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem. 2002 Jul 26;277(30):27294-304
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory