About   Help   FAQ
Prkar1atm1Gsm
Targeted Allele Detail
Summary
Symbol: Prkar1atm1Gsm
Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight
MGI ID: MGI:2183602
Gene: Prkar1a  Location: Chr11:109540231-109560482 bp, + strand  Genetic Position: Chr11, 72.33 cM
Alliance: Prkar1atm1Gsm page
Tumors in Prkar1atm1Gsm/Prkar1a+ mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78010
Parent Cell Line:  REK2 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 3 was disrupted by the insertion of a neomycin selection cassette. The absence of endcoded protein in homozygous mutant mice was confirmed via Western blot analysis. (J:78010)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkar1a Mutation:  19 strains or lines available
References
Original:  J:78010 Amieux PS, et al., Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem. 2002 Jul 26;277(30):27294-304
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
09/24/2024
MGI 6.24
The Jackson Laboratory