95 phenotypes from 6 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prkar1atm1.1Geno/Prkar1a+ involves: C57BL/6J	abnormal craniofacial bone morphology	J:303060
	abnormal craniofacial morphology	J:303060
	abnormal long bone diaphysis morphology	J:303060
	abnormal long bone epiphyseal plate morphology	J:303060
	abnormal long bone epiphyseal plate proliferative zone	J:303060
	abnormal long bone metaphysis morphology	J:303060
	abnormal skeleton development	J:303060
	abnormal trabecular bone morphology	J:303060
	abnormal urine homeostasis	J:303060
	brachydactyly	J:303060
	chondrodystrophy	J:303060
	decreased body length	J:303060
	decreased bone mineral density	J:303060
	decreased bone volume	J:303060
	decreased length of long bones	J:303060
	decreased width of hypertrophic chondrocyte zone	J:303060
	delayed endochondral bone ossification	J:303060
	female infertility	J:303060
	increased circulating parathyroid hormone level	J:303060
	postnatal growth retardation	J:303060
	short limbs	J:303060
	short snout	J:303060
	short tail	J:303060
Prkar1atm1.1Geno/Prkar1atm1.1Geno involves: C57BL/6J	prenatal lethality, complete penetrance	J:303060
Prkar1atm1.1Lsk/Prkar1a+ either: (involves: 129S1/Sv * 129X1/SvJ * C3H) or (involves: 129S1/Sv * 129X1/SvJ * A/J)	infertility	J:98799
Prkar1atm1.1Lsk/Prkar1a+ involves: 129S1/Sv * 129X1/SvJ	increased thyroid tumor incidence	J:98799
	increased tumor incidence	J:98799
Prkar1atm1.1Lsk/Prkar1a+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal bone mineralization	J:160299
	decreased bone mineral density	J:160299
	increased osteosarcoma incidence	J:160299
	increased Schwannoma incidence	J:160299
	increased skeletal tumor incidence	J:160299
	increased thyroid tumor incidence	J:160299
Prkar1atm1.1Lsk/Prkar1atm1.1Lsk involves: 129S1/Sv * 129X1/SvJ	embryonic lethality during organogenesis, complete penetrance	J:98799
Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal bone remodeling	J:165282
	increased skeletal tumor incidence	J:165282
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk Tg(Col1a1-cre)1Kry/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	neonatal lethality, complete penetrance	J:165282
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk Tg(Ghrhr-cre)3242Lsk/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	increased circulating growth hormone level	J:130264
	increased pituitary gland tumor incidence	J:130264
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk Tg(TPO-cre)1Shk/0 involves: 129S1/Sv * 129X1/SvJ * FVB/NCr	abnormal thyroid gland morphology	J:241066
	decreased thyroid-stimulating hormone level	J:241066
	enlarged thyroid gland	J:241066
	increased activity of thyroid gland	J:241066
	increased thyroid carcinoma incidence	J:225245, J:241066
	increased thyroxine level	J:241066
Prkar1atm1.2Lsk/Prkar1atm1.2Lsk Tg(Tyr-cre)3Gfk/0 either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	increased facial tumor incidence	J:98799
	increased Schwannoma incidence	J:98799
Prkar1atm1Gsm/Prkar1a+ involves: 129X1/SvJ	decreased heart rate variability	J:93393
	increased fibrosarcoma incidence	J:93393
	increased hemangiosarcoma incidence	J:93393
	increased hepatocellular carcinoma incidence	J:93393
	increased sarcoma incidence	J:93393
	increased tumor incidence	J:93393
	normal pigmentation phenotype	J:93393
	reduced male fertility	J:93393
Prkar1atm1Gsm/Prkar1atm1Gsm involves: 129X1/SvJ * C57BL/6	abnormal cardiogenic plate morphology	J:78010
	abnormal cell morphology	J:78010
	abnormal developmental patterning	J:78010
	abnormal embryo size	J:78010
	abnormal embryonic tissue morphology	J:78010
	abnormal foregut morphology	J:78010
	abnormal primitive streak morphology	J:78010
	abnormal somite shape	J:78010
	absent heart tube	J:78010
	decreased axial mesoderm size	J:78010
	decreased embryo size	J:78010
	decreased paraxial mesoderm size	J:78010
	decreased somite size	J:78010
	embryonic growth retardation	J:78010
	embryonic lethality during organogenesis, complete penetrance	J:78010
	enhanced wound healing	J:78010
	excessive folding of visceral yolk sac	J:78010
	failure of initiation of embryo turning	J:78010
Prkar1atm1Lsk/Prkar1atm1Lsk involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:98799
Prkar1atm1Lsk/Prkar1atm1Lsk Tg(Akr1b7-cre)1Anm/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	abnormal adipose tissue distribution	J:161521
	abnormal adrenal cortex morphology	J:161521
	abnormal adrenal gland physiology	J:161521
	abnormal adrenal gland zona glomerulosa morphology	J:161521
	adrenal cortical hyperplasia	J:161521
	decreased adrenal gland zona fasciculata size	J:161521
	decreased physiological sensitivity to xenobiotic	J:161521
	disorganized adrenal gland zona fasciculata	J:161521
	increased adrenal gland apoptosis	J:161521
	increased circulating corticosterone level	J:161521
	retention of the adrenal gland x-zone	J:161521
Prkar1atm2Gsm/Prkar1atm2Gsm Tg(Cr2-cre)3Cgn/0 involves: 129X1/SvJ * C57BL/6	abnormal class switch recombination	J:147785
Prkar1atm2Gsm/Prkar1atm2Gsm Tg(Plp1-cre)1Bzal/0 involves: 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2	abnormal nose morphology	J:148464
	abnormal small intestinal transit time	J:148464
	abnormal small intestine morphology	J:148464
	blepharoptosis	J:148464
	decreased body weight	J:148464
	decreased white adipose tissue amount	J:148464
	distended abdomen	J:148464
	dry eyes	J:148464
	muscular atrophy	J:148464
	premature death	J:148464
	short snout	J:148464
Prkar1atm2Gsm/Prkar1atm2Gsm Tlx2tm1.1(cre)Rpk/Tlx2+ involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/6N * DBA/2	abnormal small intestinal transit time	J:148464
	normal craniofacial phenotype	J:148464
	normal digestive/alimentary phenotype	J:148464
	distended duodenum	J:148464
	intestinal hypoperistalsis	J:148464
	intestinal obstruction	J:148464