Symbol Name ID |
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha MGI:104878 |
Darker colors indicate more annotations |
Human Phenotypes | Frontal bossing |
Brachycephaly |
Calvarial hyperostosis |
Mandibular prognathia |
Trismus |
Hypoplasia of the maxilla |
Paranasal sinus neoplasm |
Malar flattening |
Abnormal diaphysis morphology |
Bowing of the long bones |
Genu varum |
Cone-shaped epiphyses of the phalanges of the hand |
Short phalanx of finger |
Long hallux |
Short toe |
Brachydactyly |
Cone-shaped metacarpal epiphyses |
Abnormal femur morphology |
Coxa valga |
Short metatarsal |
Abnormal metaphysis morphology |
Abnormal morphology of the radius |
Dislocated radial head |
Hypoplasia of the radius |
Abnormal morphology of ulna |
Hypoplasia of the ulna |
Abnormal metacarpal morphology |
Short metacarpal |
Short palm |
Advanced ossification of carpal bones |
Micromelia |
Distal arthrogryposis |
Accelerated skeletal maturation |
Cone-shaped epiphysis |
Epiphyseal stippling |
Neonatal epiphyseal stippling |
Kyphosis |
Scoliosis |
Abnormal form of the vertebral bodies |
Hypoplastic vertebral bodies |
Narrow vertebral interpedicular distance |
Spinal canal stenosis |
Osteopenia |
Osteoporosis |
Joint dislocation |
Enchondroma |
Disease(s) Associated with PRKAR1A | ||||||||||||||||||||||||||||||||||||||||||||||
acrodysostosis | ||||||||||||||||||||||||||||||||||||||||||||||
Carney complex | ||||||||||||||||||||||||||||||||||||||||||||||
primary pigmented nodular adrenocortical disease |
Mouse Phenotypes | abnormal craniofacial bone morphology |
increased osteosarcoma incidence |
increased skeletal tumor incidence |
abnormal long bone diaphysis morphology |
abnormal long bone epiphyseal plate morphology |
abnormal long bone epiphyseal plate proliferative zone |
decreased width of hypertrophic chondrocyte zone |
abnormal long bone metaphysis morphology |
decreased length of long bones |
decreased bone mineral density |
decreased bone volume |
abnormal trabecular bone morphology |
abnormal skeleton development |
chondrodystrophy |
abnormal bone mineralization |
delayed endochondral bone ossification |
abnormal bone remodeling |
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Availability | Mouse Genotype | |||||||||||||||||
Prkar1atm1.1Geno/Prkar1a+ | ||||||||||||||||||
Prkar1atm1.1Lsk/Prkar1a+ | ||||||||||||||||||
Prkar1atm1.2Lsk/Prkar1a+ Tg(Col1a1-cre)1Kry/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/19/2024 MGI 6.23 |
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