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Symbol
Name
ID
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Frontal bossing
Brachycephaly
Calvarial hyperostosis
Mandibular prognathia
Trismus
Hypoplasia of the maxilla
Paranasal sinus neoplasm
Malar flattening
Abnormal diaphysis morphology
Bowing of the long bones
Genu varum
Cone-shaped epiphyses of the phalanges of the hand
Short phalanx of finger
Long hallux
Short toe
Brachydactyly
Cone-shaped metacarpal epiphyses
Abnormal femur morphology
Coxa valga
Short metatarsal
Abnormal metaphysis morphology
Abnormal morphology of the radius
Dislocated radial head
Hypoplasia of the radius
Abnormal morphology of ulna
Hypoplasia of the ulna
Abnormal metacarpal morphology
Short metacarpal
Short palm
Advanced ossification of carpal bones
Micromelia
Distal arthrogryposis
Accelerated skeletal maturation
Cone-shaped epiphysis
Epiphyseal stippling
Neonatal epiphyseal stippling
Kyphosis
Scoliosis
Abnormal form of the vertebral bodies
Hypoplastic vertebral bodies
Narrow vertebral interpedicular distance
Spinal canal stenosis
Osteopenia
Osteoporosis
Joint dislocation
Enchondroma
Disease(s) Associated with PRKAR1A
acrodysostosis
Carney complex
primary pigmented nodular adrenocortical disease

Mouse Phenotypes
abnormal craniofacial bone morphology
increased osteosarcoma incidence
increased skeletal tumor incidence
abnormal long bone diaphysis morphology
abnormal long bone epiphyseal plate morphology
abnormal long bone epiphyseal plate proliferative zone
decreased width of hypertrophic chondrocyte zone
abnormal long bone metaphysis morphology
decreased length of long bones
decreased bone mineral density
decreased bone volume
abnormal trabecular bone morphology
abnormal skeleton development
chondrodystrophy
abnormal bone mineralization
delayed endochondral bone ossification
abnormal bone remodeling
Availability Mouse Genotype
Prkar1atm1.1Geno/Prkar1a+
Prkar1atm1.1Lsk/Prkar1a+
Prkar1atm1.2Lsk/Prkar1a+
Tg(Col1a1-cre)1Kry/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory