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H2-Ab1
Gene Detail
 Symbol
Name
ID
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
MGI:103070
Synonyms Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-A, I-Abeta, Rmcs1
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr17:34263209-34269418 bp, + strand
From VEGA annotation of GRCm38

  6210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 2 dog

Gene Tree: H2-Ab1

Human
homologs
Human Homolog HLA-DQB1, major histocompatibility complex, class II, DQ beta 1
NCBI Gene ID 3119
neXtProt AC  NX_P01920
Human Synonyms  CELIAC1, HLA-DQB, IDDM1
Human Chr (Location)  6p21.3; chr6:32659464-32666689 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human HLA-DQB1
Alleles
and
phenotypes
All alleles(12) : Targeted(11) Spontaneous(1)
 
Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, ...
Component cell surface, early endosome, ...
Function peptide antigen binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (17)    Tissues (11)    Images (9)
Theiler Stages: 17, 20, 23, 26
Assay TypeResults
RNA in situ 15
RT-PCR 2
cDNA source data(153)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(190) Genomic(30) cDNA(154) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037120 (Evidence)
Ensembl Gene ModelENSMUSG00000073421 (Evidence)
Entrez Gene14961 (Evidence)
UniGene254067
DoTSDT.101125647, DT.101382213, DT.533732, DT.94191527
NIA Mouse Gene IndexU017850
PDB1D9K, 1F3J, 1IAK, 1IAO, 1LNU, 1MUJ, 2IAD, 3C5Z, 3C6L, 3CUP, 3MBE, 3RDT, 1JL4, 3C60
Consensus CDS ProjectCCDS37583.1
International Mouse Knockout Project StatusH2-Ab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037120 VEGA Gene Model | MGI Sequence Detail 6210 C57BL/6J ±  kb
transcript OTTMUST00000095573 VEGA | MGI Sequence Detail 1211 Not Applicable 
polypeptide OTTMUSP00000053328 VEGA | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(2) UniProt(21)
Polymorphisms All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR014745 MHC class II, alpha/beta chain, N-terminal
InterPro IPR000353 MHC class II, beta chain, N-terminal
Protein Ontology PR:000002017 MHC class II histocompatibility antigen beta chain HLA-DQB1
References (Earliest) J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
(Latest) J:207134 Mollo SB, et al., Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol. 2013 Dec 15;191(12):6052-9
All references(617)
Other
accession IDs
MGD-MRK-10378, MGD-MRK-10491, MGD-MRK-11045, MGD-MRK-11050, MGD-MRK-23932, MGI:1890696, MGI:2146934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory