H2-Ab1
Gene Detail

Symbol Name ID

H2-Ab1 histocompatibility 2, class II antigen A, beta 1 MGI:103070

Synonyms

Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-A, I-Abeta, Rmcs1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

Chr17:34263209-34269418 bp, + strand From VEGA annotation of GRCm38   6210 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 2 dog

Gene Tree: H2-Ab1

Human homologs

Human Homolog		HLA-DQB1, major histocompatibility complex, class II, DQ beta 1
NCBI Gene ID		3119
neXtProt AC		NX_P01920
Human Synonyms		CELIAC1, HLA-DQB, IDDM1
Human Chr (Location)		6p21.3; chr6:32627241-32634466 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human HLA-DQB1

Alleles and phenotypes

All alleles(10) : Targeted(9) Spontaneous(1)
 

Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, ...
Component	cell surface, early endosome, ...
Function	peptide antigen binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (17)    Tissues (11)    Images (9)
Theiler Stages: 17, 20, 23, 26

Assay Type	Results
RNA in situ	15
RT-PCR	2

cDNA source data(153)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(190) Genomic(30) cDNA(154) Primer pair(4) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037120 (Evidence)
Ensembl Gene Model	ENSMUSG00000073421 (Evidence)
Entrez Gene	14961 (Evidence)
UniGene	254067
DoTS	DT.101125647, DT.101382213, DT.533732, DT.94191527
NIA Mouse Gene Index	U017850
PDB	1D9K, 1F3J, 1IAK, 1IAO, 1LNU, 1MUJ, 2IAD, 3C5Z, 3C6L, 3CUP, 3MBE, 3RDT, 1JL4, 3C60
Consensus CDS Project	CCDS37583.1
International Mouse Knockout Project Status	H2-Ab1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037120	VEGA Gene Model | MGI Sequence Detail	6210	C57BL/6J
transcript	OTTMUST00000095573	VEGA | MGI Sequence Detail	1211	Not Applicable
polypeptide	OTTMUSP00000053328	VEGA | MGI Sequence Detail	265	Not Applicable

All sequences(78) RefSeq(2) UniProt(21)

Polymorphisms

All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003597	Immunoglobulin C1-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
InterPro	IPR011162	MHC classes I/II-like antigen recognition protein
InterPro	IPR014745	MHC class II, alpha/beta chain, N-terminal
InterPro	IPR000353	MHC class II, beta chain, N-terminal
Protein Ontology	PR:000002017	MHC class II histocompatibility antigen beta chain HLA-DQB1

References

(Earliest) J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
(Latest) J:195439 Geng S, et al., Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice. Blood. 2013 Mar 7;121(10):1690-700
All references(597)

Other accession IDs

MGD-MRK-10378, MGD-MRK-10491, MGD-MRK-11045, MGD-MRK-11050, MGD-MRK-23932, MGI:1890696, MGI:2146934