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H2-Ab1
Gene Detail
Symbol

Name
ID
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
MGI:103070
Synonyms
Abeta, A beta, H-2Ab, H2-Ab, Ia2, Ia-2, IAb, I-Ab, I-Abeta, Rmcs1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr17:34263209-34269418 bp, + strand
From VEGA annotation of GRCm38

  6210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 2 dog; 1 western clawed frog

HCOP human homology predictions: HLA-DQB1
Gene Tree: H2-Ab1

Human
homologs
HLA-DQB1, major histocompatibility complex, class II, DQ beta 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3119
neXtProt AC: NX_P01920

Human Synonyms: CELIAC1, HLA-DQB, IDDM1

Human Chr (Location): 6p21.3; chr6:32659464-32666689 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human HLA-DQB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Endonuclease-mediated(1) Spontaneous(1) Targeted(11) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.
 
Mutations Annotated to Human Diseases (1)   
Interactions
H2-Ab1 interacts with 30 markers (Mir92-2, Mir139, Mir200c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (17)    Tissues (11)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 2
cDNA source data(153)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(190) Genomic(30) cDNA(154) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000037120 (Evidence)
Ensembl Gene Model ENSMUSG00000073421 (Evidence)
Entrez Gene 14961 (Evidence)
UniGene 254067
DoTS DT.101125647, DT.101382213, DT.533732, DT.94191527
NIA Mouse Gene Index U017850
PDB 1D9K, 1F3J, 1IAK, 1IAO, 1JL4, 1LNU, 1MUJ, 2IAD, 3C5Z, 3C60, 3C6L, 3CUP, 3MBE, 3RDT, 4P23, 4P46, 4P5T
Consensus CDS Project CCDS37583.1
International Mouse Phenotyping Consortium Status H2-Ab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037120 VEGA Gene Model | MGI Sequence Detail 6210 C57BL/6J ±  kb
transcript OTTMUST00000095573 VEGA | MGI Sequence Detail 1211 Not Applicable 
polypeptide OTTMUSP00000053328 VEGA | MGI Sequence Detail 265 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(2) UniProt(21)
Polymorphisms
All PCR and RFLP(10) : PCR(1) RFLP(9) SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR014745 MHC class II, alpha/beta chain, N-terminal
InterPro IPR000353 MHC class II, beta chain, N-terminal
Protein Ontology PR:000002017 MHC class II histocompatibility antigen beta chain HLA-DQB1
References
(Earliest) J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
(Latest) J:222732 Rouhani SJ, et al., Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015;6:6771
All references(639)
Other
accession IDs
MGD-MRK-10378, MGD-MRK-10491, MGD-MRK-11045, MGD-MRK-11050, MGD-MRK-23932, MGI:1890696, MGI:2146934

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory