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Phenotype Images associated with this Transgene
Nomenclature
Symbol: Tg(CAG-cre/Esr1*)5Amc
Name: transgene insertion 5, Andrew P McMahon
MGI ID: MGI:2182767
Synonyms: CAG-CreEr, CAGG-Cre, CaggCreER, CAGGCre-ER, CAGGCre-ERTM, CAGGCre-ERtm line 5.8, CAGGS-CreER, CAGGS-CreErT, CMV-creERT, Cre-ER, Cre-ERTM, CreESRT, ER-cre, Tg:Cag-Cre/Esr1, Tg(CAG-cre/Esr1)5Amc, TgCAGGCreER, TgCreER, Tg(cre/Esr1)5Amc, uCreERT
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
VEGF-C-and galectin-8-induced lymphangiogenesis is diminished in Pdpntm2.1Mlkn/Pdpntm2.1Mlkn Tg(CAG-cre/Esr1*)5Amc/0 micePdpntm2.1Mlkn/Pdpntm2.1Mlkn
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129 * C57BL/6
Exocrine pancreatic insufficiency in Sel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0 miceSel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi
Tg(CAG-cre/Esr1*)5Amc/0		involves: C57BL/6 * C57BL/6N * CBA * SJL
Dilated endoplasmic reticulum and smaller zymogen granules in the exocrine pancreas of Sel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0 miceSel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi
Tg(CAG-cre/Esr1*)5Amc/0		involves: C57BL/6 * C57BL/6N * CBA * SJL
Sel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0 mice develop exocrine pancreatic insufficiency and nutrient malabsorptionSel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi
Tg(CAG-cre/Esr1*)5Amc/0		involves: C57BL/6 * C57BL/6N * CBA * SJL
Decreased cell proliferation in the exocrine pancreas in Sel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0 miceSel1ltm1c(KOMP)Wtsi/Sel1ltm1c(KOMP)Wtsi
Tg(CAG-cre/Esr1*)5Amc/0		involves: C57BL/6 * C57BL/6N * CBA * SJL
Impaired lung morphology in Edn2tm1Ywa/Edn2tm1Ywa mice and tamoxifen-treated Edn2tm1.1Nat/Edn2tm1.1Nat Tg(CAG-cre/Esr1*)5Amc/0 miceEdn2tm1.1Nat/Edn2tm1.1Nat
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Edn2tm1Ywa/Edn2tm1Ywainvolves: 129S6/SvEvTac
Obesity in Pomctm2Low/Pomctm2Low Tg(CAG-cre/Esr1*)5Amc/0 females and weight loss following tamoxifen treatmentPomctm2Low/Pomctm2Low
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S4/SvJae * C57BL/6 * CBA
Adult rods are reprogrammed into cone-like cells in Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 miceNrltm1Jcco/Nrltm1Jcco
Tg(CAG-cre/Esr1*)5Amc/0		involves: C57BL/6 * CBA
Rod reprogramming prevents retinal degeneration in tamoxifen treated Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 miceNrltm1Jcco/Nrltm1Jcco
Rhotm1Jlem/Rhotm1Jlem
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S4/SvJae * C57BL/6 * CBA
Outer nuclear layer of the retina is preserved in tamoxifen treated Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 miceNrltm1Jcco/Nrltm1Jcco
Rhotm1Jlem/Rhotm1Jlem
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S4/SvJae * C57BL/6 * CBA
Hair loss and dry skin in tamoxifen treated Mcattm1.1Ssmi/Mcattm1.1Ssmi Tg(CAG-cre/Esr1*)5Amc/0 miceMcattm1.1Ssmi/Mcattm1.1Ssmi
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Abnormal skin morphology in tamoxifen-treated Mcattm1.1Ssmi/Mcattm1.1Ssmi Tg(CAG-cre/Esr1*)5Amc/0 miceMcattm1.1Ssmi/Mcattm1.1Ssmi
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Presence of enlarged red blood cells and codocytes in the blood of tamoxifen-treated anemic Mcattm1.1Ssmi/Mcattm1.1Ssmi Tg(CAG-cre/Esr1*)5Amc/0 miceMcattm1.1Ssmi/Mcattm1.1Ssmi
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Representative images of grossly deformed, nonviable Trpm7tm1Clph/Trpm7tm1Clph Tg(CAG-cre/Esr1*)5Amc/0 embryos at E9.5 and E10.5Trpm7tm1Clph/Trpm7tm1Clph
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S4/SvJae * C57BL/6 * CBA
Atrioventricular block in tamoxifen treated Tbx3tm3.1Moon/Tbx3tm3.1Moon Tg(CAG-cre/Esr1*)5Amc/0 miceTbx3tm3.1Moon/Tbx3tm3.1Moon
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129 * C57BL/6
Thymic atrophy in tamoxifen treated Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 miceFoxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129/Sv * C57BL/6 * CBA * SJL
Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0		involves: 129/Sv * C57BL/6 * SJL
Hair follicles of tamoxifen-treated Lhx2tm1.1Lcar/Lhx2tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaftLhx2tm1.1Lcar/Lhx2tm1Dra
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S4/SvJae * C57BL/6 * CBA
Small and lean phenotype of Ate1tm1Avar/Ate1tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 miceAte1tm1Avar/Ate1tm2.1Avar
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * C57BL/6 * CBA
Kyphoid posture of an Ate1tm1Avar/Ate1tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 mouseAte1tm1Avar/Ate1tm2.1Avar
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * C57BL/6 * CBA
Enlarged brains of Ate1tm1Avar/Ate1tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 miceAte1tm1Avar/Ate1tm2.1Avar
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * C57BL/6 * CBA
Sperm tails in the lumens of Ate1tm1Avar/Ate1tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 seminiferous tubules are sparseAte1tm1Avar/Ate1tm2.1Avar
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * C57BL/6 * CBA
Decreased lipid content of Ate1tm2.1Avar/Ate1tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 adipocytesAte1tm1Avar/Ate1tm2.1Avar
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * C57BL/6 * CBA
Spindle defects in primay Numa1tm1.1Dwc/Numa1tm1.1Dwc Tg(CAG-cre/Esr1*)5Amc/0 fibroblastsNuma1tm1.1Dwc/Numa1tm1.1Dwc
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Reduced spindle tension and efficiency of chromosome alignment in Numa1tm1.1Dwc/Numa1tm1.1Dwc Tg(CAG-cre/Esr1*)5Amc/0 fibroblastsNuma1tm1.1Dwc/Numa1tm1.1Dwc
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Thymic atrophy in Supv3l1tm2.1Jkl/Supv3l1tm2.2Jkl Tg(CAG-cre/Esr1*)5Amc/0 miceSupv3l1tm2.1Jkl/Supv3l1tm2.2Jkl
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Kyphosis and scaling on feet develop in Supv3l1tm2Jkl/Supv3l1tm2Jkl Tg(CAG-cre/Esr1*)5Amc/0 mice following tamoxifen treatmentSupv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * C57BL/6
Skin abnormalities in various conditional Supv3l1 mutantsSupv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(Mx1-cre)1Cgn/0		involves: 129P2/OlaHsd * C57BL/6 * CBA
Supv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * C57BL/6
Supv3l1tm2.1Jkl/Supv3l1tm2.2Jkl
Tg(KRT14-cre/ERT)20Efu/0		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CD-1 * FVB/N
Lung, spleen, and duodenum abnormalities in conditional Supv3l1 mutantsSupv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(Mx1-cre)1Cgn/0		involves: 129P2/OlaHsd * C57BL/6 * CBA
Supv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(CAG-cre/Esr1*)5Amc/0		involves: 129P2/OlaHsd * C57BL/6
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory