Phenotype Image Detail

Image

Caption

Dilated endoplasmic reticulum (ER) and smaller zymogen granules in the exocrine pancreas of Sel1l^{tm1c(KOMP)Wtsi}/Sel1l^{tm1c(KOMP)Wtsi} Tg(CAG-cre/Esr1*)5Amc/0 (IKO) mice. Pancreas was harvested at day 12. (A) Representative transmission electron microscopy (TEM) images of exocrine pancreas of wild-type (WT) and mutant mice showing a profound dilation of the ER. (B) Representative TEM images of exocrine pancreas of WT and mutant mice showing smaller secretory granules. Asterisks indicate the acinar lumen; N, nucleus; M, mitochondrion; ZG, zymogen granules; ER, endoplasmic reticulum; and Mv, Microvillus. Scale bar shown. (C) Quantitation of granule sizes in 100 granules each genotype in histogram (Left) and Whiskers plot (Right). In the Whiskers plot, the medium, the 25th to 75th percentiles and the minimum to maximum range of granule sizes are shown. n = 3 mice each group. Data are mean +/- SEM. ***P < 0.001 by Student t test.

Copyright

This image is from Sun S, Proc Natl Acad Sci U S A 2014 Feb 4;111(5):E582-91. Copyright 2014 National Academy of Sciences, U.S.A. J:206568

Associated Alleles

Symbol	Name
Sel1l^tm1c(KOMP)Wtsi	sel-1 suppressor of lin-12-like (C. elegans); targeted mutation 1c, Welcome Trust Sanger Institute
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon

Associated Genotypes

Allelic Composition	Genetic Background
Sel1l^tm1c(KOMP)Wtsi/Sel1l^tm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * C57BL/6N * CBA * SJL