Lhx2tm1Dra
Targeted Allele Detail
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Symbol: |
Lhx2tm1Dra |
Name: |
LIM homeobox protein 2; targeted mutation 1, John Drago |
MGI ID: |
MGI:1890208 |
Synonyms: |
Lh2sKO, Lhx - |
Gene: |
Lhx2 Location: Chr2:38229293-38259745 bp, + strand Genetic Position: Chr2, 24.31 cM, cytoband B
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Alliance: |
Lhx2tm1Dra page
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Hair follicles of tamoxifen-treated Lhx2tm1.1Lcar/Lhx2tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaft
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:64676
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced exons 2 and 3, which encode the LIM domains, the domain linking these two, and the homeodomains of the protein.
(J:64676)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lhx2 Mutation: |
12 strains or lines available
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Original: |
J:64676 Porter FD, et al., Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. 1997 Aug;124(15):2935-44 |
All: |
40 reference(s) |
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