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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp3tm4(YFP/icre)Ayr
targeted mutation 4, Alexander Y Rudensky
MGI:3790499
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Socs1tm1Ayos/Socs1tm1Ayos
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4887825
cn2
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ MGI:5448156
cn3
Foxo1tm1Flv/Foxo1tm1Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:5448157
cn4
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:4943576
cn5
B9d2/Tgfb1tm1Flv/B9d2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:4943575
cn6
Foxo1tm1Flv/Foxo1tm1Flv
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:5448151
cn7
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ MGI:3806256
cn8
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ MGI:3806255
cn9
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
involves: 129S1/Sv * 129X1/SvJ MGI:5547376
cn10
Nr4a2tm1.1Pcn/Nr4a2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ MGI:5547375
cn11
Il10tm1Roer/Il10tm1Roer
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3790650
cn12
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5448149
cn13
Cd28tm1Ltu/Cd28tm1Ltu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5485238
cn14
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5546602
cn15
Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563102
cn16
Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563103
cn17
Myd88tm1.1Medz/Myd88tm1.1Medz
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5616083
cn18
Droshatm1Litt/Droshatm1.1Litt
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3806254
cn19
Droshatm1Litt/Droshatm1.1Litt
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3806253
cn20
Aregtm2c(EUCOMM)Hmgu/Aregtm2c(EUCOMM)Hmgu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N MGI:5806476
cn21
Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5562712
cn22
Cishtm1.1Cdon/Cishtm1.1Cdon
Foxp3tm4(YFP/icre)Ayr/Foxp3+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 MGI:5544440


Genotype
MGI:4887825
cn1
Allelic
Composition
Socs1tm1Ayos/Socs1tm1Ayos
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Socs1tm1Ayos mutation (1 available); any Socs1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• by 6 weeks of age
• by 6 weeks of age
• by 6 weeks of age

integument
• by 6 weeks of age

vision/eye
• by 6 weeks of age
• by 6 weeks of age

hematopoietic system




Genotype
MGI:5448156
cn2
Allelic
Composition
Foxo1tm1Flv/Foxo1tm1Flv
Ifngtm1Ts/Ifngtm1Ts
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (1 available); any Foxo1 mutation (6 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Ifngtm1Ts mutation (18 available); any Ifng mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• the lethal inflammatory phenotype is partially rescued

immune system
N
• regulatory T cells are able to suppress development of colitis in Rag1 null mice receiving naive T cells
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3tm4(YFP/cre)Ayr/Foxp3+ mice
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3tm4(YFP/cre)Ayr/Foxp3+ mice

hematopoietic system
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3tm4(YFP/cre)Ayr/Foxp3+ mice
• elevated numbers in the spleen and peripheral lymph nodes are partially rescued compared to in Foxo1tm1Flv/Foxo1tm1Flv Foxp3tm4(YFP/cre)Ayr/Foxp3+ mice




Genotype
MGI:5448157
cn3
Allelic
Composition
Foxo1tm1Flv/Foxo1tm1Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (1 available); any Foxo1 mutation (6 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

mortality/aging
• moribund within 35 days of birth

immune system
• in the spleen and peripheral lymph node
• in the spleen and peripheral lymph nodes
• in the spleen and peripheral lymph nodes
• in peripheral lymph node at day 20
• however, thymic and splenic regulatory T cell numbers are normal at day 12
• regulatory T cells are not able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells unlike wild-type regulatory T cells
• infiltrate of leukocytes in the salivary glands, lung interstitia, liver sinusoids, pancreas acini, stomach and colon mucosa

behavior/neurological
• lack of mobility associated with hunched posture
• lack of mobility associated with hunched posture

integument
• crusting of the ears, eyelids and tail

limbs/digits/tail
• scurfy tail

hematopoietic system
• in the spleen and peripheral lymph node
• in the spleen and peripheral lymph nodes
• in the spleen and peripheral lymph nodes
• in peripheral lymph node at day 20
• however, thymic and splenic regulatory T cell numbers are normal at day 12
• regulatory T cells are not able to suppress development of colitis in Rag1 null mice receiving na[?]ve T cells unlike wild-type regulatory T cells




Genotype
MGI:4943576
cn4
Allelic
Composition
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any Tgfb1 mutation (22 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Tgfb1tm2Flv mutation (0 available); any Tgfb1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice

hematopoietic system
• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell

immune system
N
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice
• mice exhibit normal susceptibility to experimental autoimmune encephalomyelitis and Th17 cell differentiation
• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell




Genotype
MGI:4943575
cn5
Allelic
Composition
B9d2/Tgfb1tm1Flv/B9d2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (8 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice
• mice exhibit normal susceptibility to experimental autoimmune encephalomyelitis and Th17 cell differentiation
• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell

growth/size/body
N
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice

hematopoietic system
• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell




Genotype
MGI:5448151
cn6
Allelic
Composition
Foxo1tm1Flv/Foxo1tm1Flv
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Flv mutation (1 available); any Foxo1 mutation (6 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli mutation (1 available); any Gt(ROSA)26Sor mutation (510 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• the lethal inflammatory phenotype is completely rescued

immune system
N
• the lethal inflammatory phenotype is completely rescued




Genotype
MGI:3806256
cn7
Allelic
Composition
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (4 available); any Dicer1 mutation (61 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• males become ill at 2-3 weeks, exhibiting 100% mortality at <25 days

immune system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
• large areas are infiltrated by inflammatory cells in moribund mice
• large areas are infiltrated by inflammatory cells in moribund mice

hematopoietic system

cardiovascular system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed

liver/biliary system
• large areas are infiltrated by inflammatory cells in moribund mice

respiratory system
• large areas are infiltrated by inflammatory cells in moribund mice




Genotype
MGI:3806255
cn8
Allelic
Composition
Dicer1tm1Bdh/Dicer1tm1Bdh
Foxp3tm4(YFP/icre)Ayr/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (4 available); any Dicer1 mutation (61 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females become ill at 2-3 weeks, exhibiting 100% mortality at <25 days

immune system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
• large areas are infiltrated by inflammatory cells in moribund mice
• large areas are infiltrated by inflammatory cells in moribund mice

hematopoietic system

cardiovascular system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed

liver/biliary system
• large areas are infiltrated by inflammatory cells in moribund mice

respiratory system
• large areas are infiltrated by inflammatory cells in moribund mice




Genotype
MGI:5547376
cn9
Allelic
Composition
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Nr4a2tm1.1Pcn/Nr4a2tm1.1Pcn
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• regulatory T cells are not properly maintained
• slightly attenuated suppressive activity
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells

hematopoietic system
• regulatory T cells are not properly maintained
• slightly attenuated suppressive activity
• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells




Genotype
MGI:5547375
cn10
Allelic
Composition
Nr4a2tm1.1Pcn/Nr4a2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Nr4a2tm1.1Pcn mutation (0 available); any Nr4a2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Treg cells are not properly maintained

hematopoietic system
• Treg cells are not properly maintained




Genotype
MGI:3790650
cn11
Allelic
Composition
Il10tm1Roer/Il10tm1Roer
Foxp3tm4(YFP/icre)Ayr/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Il10tm1Roer mutation (0 available); any Il10 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• starting at 10 weeks of age, mice present with the gross manifestations of colitis including colonic thickening and substantial increase in the size of mesenteric lymph nodes
• histological examinations reveals prominent mononuclear infiltration of epithelial tissues as well as tissue destruction of the cecum and portions of the colon
• disease is similar to what is observed in Il10tm1Cgn null mice though with less severity and incidence, and a slightly later onset

immune system
• starting at 10 weeks of age, mice present with the gross manifestations of colitis including colonic thickening and substantial increase in the size of mesenteric lymph nodes
• histological examinations reveals prominent mononuclear infiltration of epithelial tissues as well as tissue destruction of the cecum and portions of the colon
• disease is similar to what is observed in Il10tm1Cgn null mice though with less severity and incidence, and a slightly later onset
• Foxp3 expressing regulatory CD4 T cells fail to produce IL-10
• mice exhibit spontaneous colitis and inflammation in the lung that is contributable to defective regulatory T cell responses
• mice also have heightened inflammatory responses when challenged with antigen to the lungs or skin
• there is a substantial increase in ear thickness and inflammation after application of dinitrofluorobenzene (DNFB) on the ear
• T cells infiltrating the site of DNFB application have higher expression of the activation marker CD69
• there is no difference in the number of FoxP3 regulatory T cells found at the site of inflammation when compared to control mice suggesting the inability to make IL-10 is affecting regulator T cell function
• IL-10 producing T cells are greatly diminished by the Foxp3-expressing, but not Foxp3 negative, CD4+ T cell subset
• there is almost a two-fold reduction in the number of lamina propria Foxp3 negative lymphocytes that produce IL-10
• mice have mild perivasculitis and moderate mononuclear infiltration around large airways in the lungs
• inducing lung inflammation by sensitizing and then challenging mice with OVA peptide leads to more pronounced inflammatory response with 2.7 fold increase in leukocytes numbers from bronchoalveolar lavage fluid
• OVA induced inflammation leads to markedly increased mucus production, goblet cell expansion, edema, and increased eosinophilic infiltration around major airways
• OVA treated mice also show a marked increase in airway hyperreactivity to aerosolized methacholine

respiratory system
• mice have mild perivasculitis and moderate mononuclear infiltration around large airways in the lungs
• inducing lung inflammation by sensitizing and then challenging mice with OVA peptide leads to more pronounced inflammatory response with 2.7 fold increase in leukocytes numbers from bronchoalveolar lavage fluid
• OVA induced inflammation leads to markedly increased mucus production, goblet cell expansion, edema, and increased eosinophilic infiltration around major airways
• OVA treated mice also show a marked increase in airway hyperreactivity to aerosolized methacholine

hematopoietic system
• Foxp3 expressing regulatory CD4 T cells fail to produce IL-10
• mice exhibit spontaneous colitis and inflammation in the lung that is contributable to defective regulatory T cell responses
• mice also have heightened inflammatory responses when challenged with antigen to the lungs or skin




Genotype
MGI:5448149
cn12
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Gt(ROSA)26Sortm1(CAG-FOXO1,GFP)Moli mutation (1 available); any Gt(ROSA)26Sor mutation (510 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal regulatory T cell differentiation and homeostasis




Genotype
MGI:5485238
cn13
Allelic
Composition
Cd28tm1Ltu/Cd28tm1Ltu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28tm1Ltu mutation (1 available); any Cd28 mutation (29 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Skin inflammation and enlarged lymph nodes and spleen in Cd28tm1Ltu/Cd28tm1Ltu Foxp3tm4(YFP/icre)Ayr/Foxp3+ mice

cellular
• reduced proliferation of T regulatory cells in the thymus but not spleen or lymph nodes

immune system
• reduced proliferation of T regulatory cells in the thymus but not spleen or lymph nodes
• in the lymph node
• in the thymus but not lymph node or spleens
• in the thymus and periphery of female mice at 3 months
• in the lymph nodes and spleen at 2 to 5 months
• with IFN-gamma expression
• at 2 to 5 months with accumulation of activated T cells
• at 2 to 5 months with accumulation of activated T cells
• by 8 to 12 weeks with crusting eyelids, facial hair loss, which progressed to hair loss on the trunk, skin lesions, an ill appearance, ruffled fur, hunching and reduced movements
• however, CD28-sufficient regulatory T cells prevent the autoimmune disease development
• 20 days after immunization, mice treated with rMOG/CFA plus pertussis toxin exhibit increased clinical score and fail to recover compared with wild-type mice
• at 2 to 5 months

integument
• at 2 to 5 months
• facial hair loss, which progressed to hair loss on the trunk by 8 to 12 weeks
• by 8 to 12 weeks
• by 8 to 12 weeks

behavior/neurological
• by 8 to 12 weeks
• by 8 to 12 weeks

vision/eye
• crusting by 8 to 12 weeks

hematopoietic system
• reduced proliferation of T regulatory cells in the thymus but not spleen or lymph nodes
• in the lymph node
• in the thymus but not lymph node or spleens
• in the thymus and periphery of female mice at 3 months
• in the lymph nodes and spleen at 2 to 5 months
• with IFN-gamma expression
• at 2 to 5 months with accumulation of activated T cells




Genotype
MGI:5546602
cn14
Allelic
Composition
Nr4a1tm1Pcn/Nr4a1tm1Pcn
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Nr4a1tm1Pcn mutation (0 available); any Nr4a1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the ratio of YFP+/YFP- regulatory T cells is normal




Genotype
MGI:5563102
cn15
Allelic
Composition
Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Gt(ROSA)26Sortm1Hjf mutation (4 available); any Gt(ROSA)26Sor mutation (510 available)
Itchtm1.1Alta mutation (0 available); any Itch mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• regulatory T cells exhibit normal suppressive functions and stability




Genotype
MGI:5563103
cn16
Allelic
Composition
Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Itchtm1.1Alta mutation (0 available); any Itch mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• from 6 weeks of age

immune system
N
• mice exhibit normal response to experimental autoimmune encephalomyelitis
• from 6 weeks of age, mice exhibit a lymphoproliferative disorder unlike wild-type mice
• increased when induced by regulatory T cells
• however, anti-IL4 antibody abolishes Th2 instruction
• slightly decreased proportion in the spleen
• in splenic red pulp
• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
• modestly
• ovalbumin-specific IgE in ovalbumin-treated mice
• CD4+ T cells and anti-CD3-stimulated splenocytes produce more Th2 cytokines (IL4, IL5 and IL10) compared with wild-type mice
• when injected into ovalbumin-immunized wild-type mice, regulatory T cells exacerbate Th2 immune responses in allergic reaction compared with wild-type cells
• however, regulatory T cells exhibit normal suppressive functions and stability
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells
• from 6 weeks of age, mice exhibit larger size and cellularity of peripheral lymphoid organs compared with wild-type mice
• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
• from anti-CD3-stimulated splenocytes
• from CD4+ T cells in the lungs
• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
• massive infiltration in the lungs, stomach, skin and liver
• however, no lesions are observed in the kidney and colon
• from 6 weeks of age
• more severe when induced by ovalbumin with increased total cells and eosinophils in the bronchoalveolar lavage fluid
• severe at 16 weeks

integument
• severe at 16 weeks
• from 6 weeks of age

respiratory system
• from 6 weeks of age
• more severe when induced by ovalbumin with increased total cells and eosinophils in the bronchoalveolar lavage fluid

growth/size/body
• from 6 weeks of age

cellular
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells

hematopoietic system
• from 6 weeks of age, mice exhibit a lymphoproliferative disorder unlike wild-type mice
• increased when induced by regulatory T cells
• however, anti-IL4 antibody abolishes Th2 instruction
• slightly decreased proportion in the spleen
• in splenic red pulp
• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
• modestly
• ovalbumin-specific IgE in ovalbumin-treated mice
• CD4+ T cells and anti-CD3-stimulated splenocytes produce more Th2 cytokines (IL4, IL5 and IL10) compared with wild-type mice
• when injected into ovalbumin-immunized wild-type mice, regulatory T cells exacerbate Th2 immune responses in allergic reaction compared with wild-type cells
• however, regulatory T cells exhibit normal suppressive functions and stability
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells




Genotype
MGI:5616083
cn17
Allelic
Composition
Myd88tm1.1Medz/Myd88tm1.1Medz
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
Myd88tm1.1Medz mutation (0 available); any Myd88 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice mount CD4+ T cell responses in response to immunization with OVA and LPS that are indistinguishable from wild-type mice




Genotype
MGI:3806254
cn18
Allelic
Composition
Droshatm1Litt/Droshatm1.1Litt
Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1.1Litt mutation (0 available); any Drosha mutation (24 available)
Droshatm1Litt mutation (1 available); any Drosha mutation (24 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• females become ill at 2-3 weeks, exhibiting 100% mortality at <25 days

immune system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
• decrease in Foxp3+ CD25lo population
• moribund mice display splenomegaly
• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation
• moribund mice display massive lymphadenopathy at 2.5-3 weeks of age
• hyper-Ifng secretion by CD4+ and CD8+ T cells is observed
• hyper-Il-4 secretion by CD4+ T cells is observed
• large areas are infiltrated by inflammatory cells in moribund mice
• large areas are infiltrated by inflammatory cells in moribund mice

hematopoietic system
• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
• decrease in Foxp3+ CD25lo population
• moribund mice display splenomegaly
• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation

cardiovascular system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed

liver/biliary system
• large areas are infiltrated by inflammatory cells in moribund mice

respiratory system
• large areas are infiltrated by inflammatory cells in moribund mice




Genotype
MGI:3806253
cn19
Allelic
Composition
Droshatm1Litt/Droshatm1.1Litt
Foxp3tm4(YFP/icre)Ayr/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Droshatm1.1Litt mutation (0 available); any Drosha mutation (24 available)
Droshatm1Litt mutation (1 available); any Drosha mutation (24 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• males become ill at 2-3 weeks, exhibiting 100% mortality at <25 days

cardiovascular system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed

hematopoietic system
• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
• moribund mice display splenomegaly
• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation

immune system
• cuffing around blood vessels by inflammatory cells in pancreas, kidney and skeletal muscle is observed
• all leukocyte populations are expanded equally, except for consistent increase observed in CD8+ T cell number
• moribund mice display splenomegaly
• increased frequencies of CD62Llo44hi CD4+ and CD8+ T cells are observed, indicating aberrant activation
• moribund mice display massive lymphadenopathy at 2.5-3 weeks of age
• hyper-Ifng secretion by CD4+ and CD8+ T cells is observed
• hyper-IL-4 secretion by CD4+ T cells is observed
• large areas are infiltrated by inflammatory cells in moribund mice
• large areas are infiltrated by inflammatory cells in moribund mice

liver/biliary system
• large areas are infiltrated by inflammatory cells in moribund mice

respiratory system
• large areas are infiltrated by inflammatory cells in moribund mice




Genotype
MGI:5806476
cn20
Allelic
Composition
Aregtm2c(EUCOMM)Hmgu/Aregtm2c(EUCOMM)Hmgu
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aregtm2c(EUCOMM)Hmgu mutation (0 available); any Areg mutation (7 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• contrary to germ line deletion, mice are born in Mendelian ratios with no gender bias

immune system
N
• mice exhibit normal frequencies and numbers of B and T cells and activated T cells
• unchallenged mice exhibit no heightened inflammatory response and normal T regulator cell suppressor function
• flu-infected mice exhibit a greater decrease in average blood oxygen saturation, overall lung tissue damage and decreased surface temperature compared with wild-type mice
• however, flu-infected mice exhibit normal T cell activation and T regulatory cell mediated suppression of anti-vial immunity

homeostasis/metabolism
• flu-infected mice exhibit a greater decrease in average blood oxygen saturation compared with wild-type mice
• however, mice do not exhibit anemia
• however, core body temperature is normal
• in flu-infected mice




Genotype
MGI:5562712
cn21
Allelic
Composition
Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm6.1Boui mutation (0 available); any Bcl2l11 mutation (15 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased frequency at 2 months that may be due to increased thymic output
• further increase at 6 months as in Bcl2l11tm1.1Ast homozygotes

immune system
• increased frequency at 2 months that may be due to increased thymic output
• further increase at 6 months as in Bcl2l11tm1.1Ast homozygotes




Genotype
MGI:5544440
cn22
Allelic
Composition
Cishtm1.1Cdon/Cishtm1.1Cdon
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background
involves: 129S/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cishtm1.1Cdon mutation (0 available); any Cish mutation (7 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal asthmatic response





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory