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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pax6-cre,GFP)2Pgr
transgene insertion 2, Peter Gruss
MGI:3052661
Summary 32 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 MGI:5705506
cn2
Pou4f1tm1Nat/Pou4f1tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 * 129S7/SvEvBrd MGI:3842429
cn3
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 * C57BL/6 * FVB/N MGI:4437797
cn4
E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722927
cn5
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722928
cn6
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Nphp1tm1Jgg/Nphp1+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:4437798
cn7
E2f2tm1Zubi/E2f2tm1Zubi
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722916
cn8
E2f1tm1Meg/E2f1+
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722917
cn9
E2f1tm1Meg/E2f1tm1Meg
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722918
cn10
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722920
cn11
Atrxtm1Rjg/Y
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3834848
cn12
Kdrtm2Sato/Kdrtm2Sato
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv MGI:5705505
cn13
Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+
Ngfrtm1Klee/Ngfrtm1Klee
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv MGI:3835510
cn14
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 MGI:5705503
cn15
Kdrtm1Ykub/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ MGI:5705499
cn16
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ MGI:5705500
cn17
Pax6tm2Pgr/Pax6+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ MGI:4821787
cn18
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5544088
cn19
Dscamtm1Pfu/Dscamtm1Pfu
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5305027
cn20
Ednrbtm1.1Nat/Ednrbtm1.2Nat
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5544090
cn21
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/SvImJ * C57BL/6 MGI:5705502
cn22
Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N MGI:3707433
cn23
Vhltm1Jae/Vhltm1Jae
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S4/SvJae MGI:5705504
cn24
Pcdhgtm2Xzw/Pcdhgtm2Xzw
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S7/SvEvBrd * C57BL/6J MGI:3821863
cn25
Sox2tm1Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv MGI:3625926
cn26
Sox2tm2Lpev/Sox2tm2.1Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv MGI:3713886
cn27
Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv MGI:3625927
cn28
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3707434
cn29
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3707432
cn30
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Not Specified MGI:3783526
cn31
Pax6tm1.1Zkoz/Pax6tm1.1Zkoz
Tg(Pax6-cre,GFP)2Pgr/0
Not Specified MGI:5567086
cx32
Pou4f2tm1Nat/Pou4f2tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S7/SvEvBrd MGI:3842430


Genotype
MGI:5705506
cn1
Allelic
Composition
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
Vegfatm2Gne mutation (0 available); any Vegfa mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• some arteriovenous crossings is observed

vision/eye
• some arteriovenous crossings is observed




Genotype
MGI:3842429
cn2
Allelic
Composition
Pou4f1tm1Nat/Pou4f1tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1Nat mutation (0 available); any Pou4f1 mutation (6 available)
Pou4f1tm2.1Nat mutation (1 available); any Pou4f1 mutation (6 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated

vision/eye
• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated




Genotype
MGI:4437797
cn3
Allelic
Composition
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (31 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (31 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:3722927
cn4
Allelic
Composition
E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (14 available)
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (17 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• bipolar and ganglion cell death, starburst amacrine cell (SAC) differentiation, and SAC track disorder observed in Rbl1 null, Rbl1/E2f3 null or Rbl1/E2f1 null mice are rescued




Genotype
MGI:3722928
cn5
Allelic
Composition
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the optic nerve is thin due to the loss of retinal ganglion cells
• retinal transition (RTC) undergo ectopic DNA synthesis and increased apoptosis
• at P8 or P18 when cell division is completed in the wild-type retina, ectopic RTC divisions are detected
• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina
• apoptosis eliminates most retinal ganglion cells
• apoptosis eliminates many rod cells
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer
• Slc18a3 staining of mature SACs is absent from the peripheral retina
• however, SAC survival and process outgrowth is normal
• as markers of differentiation are detected early in the cell body if at all, synthesis or stability and transport of SAC markers is defective
• 5.6% of Camk2+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 3.7% in Rbl1/E2f1 null mice and 91% in Rbl1/E2f3 null mice
• apoptosis eliminates most bipolar cells
• after P8, mice exhibit a reduction in Callb2+ starburst amacrine ccell bodies, indicative of amacrine cells
• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer
• the outer nuclear layer is thin due to the loss of rods
• light-adapted (photopic) response is defective
• the response to dim light in dark-adapted (scotopic) conditions is defective

nervous system
• apoptosis eliminates most retinal ganglion cells
• apoptosis eliminates many rod cells
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer
• Slc18a3 staining of mature SACs is absent from the peripheral retina
• however, SAC survival and process outgrowth is normal
• as markers of differentiation are detected early in the cell body if at all, synthesis or stability and transport of SAC markers is defective
• 5.6% of Camk2+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 3.7% in Rbl1/E2f1 null mice and 91% in Rbl1/E2f3 null mice
• apoptosis eliminates most bipolar cells
• the optic nerve is thin due to the loss of retinal ganglion cells




Genotype
MGI:4437798
cn6
Allelic
Composition
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Nphp1tm1Jgg/Nphp1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (31 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (31 available)
Nphp1tm1Jgg mutation (1 available); any Nphp1 mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:3722916
cn7
Allelic
Composition
E2f2tm1Zubi/E2f2tm1Zubi
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2tm1Zubi mutation (1 available); any E2f2 mutation (15 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice
• apoptosis eliminates many rod cells as in Rbl1 null mice
• apoptosis eliminates most bipolar cells as in Rbl1 null mice
• retinal transition cells (RTC) undergo ectopic cell divisions as in Rbl1 null mice

nervous system
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice
• apoptosis eliminates many rod cells as in Rbl1 null mice
• apoptosis eliminates most bipolar cells as in Rbl1 null mice




Genotype
MGI:3722917
cn8
Allelic
Composition
E2f1tm1Meg/E2f1+
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (14 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• ectopic retinal transition cell division observed in Rbl1 null mice is partially suppressed




Genotype
MGI:3722918
cn9
Allelic
Composition
E2f1tm1Meg/E2f1tm1Meg
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (14 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina
• however, retinal transition cell division, rod cell numbers, retinal differentiation and rod function are normal
• mice have slightly fewer ganglion cells at P0
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer
• Slc18a3 staining of mature SACs is absent from the peripheral retina
• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice
• mice have slightly fewer bipolar cells at P18 or P30
• however, the proportion of bipolar cells is normal
• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer
• the retinal outer nuclear layer is slightly reduced in thickness at P18 or P30
• photopic response is very slightly reduced

nervous system
• mice have slightly fewer ganglion cells at P0
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer
• Slc18a3 staining of mature SACs is absent from the peripheral retina
• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice
• mice have slightly fewer bipolar cells at P18 or P30
• however, the proportion of bipolar cells is normal




Genotype
MGI:3722920
cn10
Allelic
Composition
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (17 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• apoptosis eliminates most retinal ganglion cells
• apoptosis eliminates many rod cells
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells
• however, markers of SAC differentiation are restored
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis
• apoptosis eliminates most bipolar cells
• retinal transition cells (RTC) undergo ectopic cell divisions
• however, markers of starburst amacrine cell differentiation are restored

nervous system
• apoptosis eliminates most retinal ganglion cells
• apoptosis eliminates many rod cells
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells
• however, markers of SAC differentiation are restored
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis
• apoptosis eliminates most bipolar cells




Genotype
MGI:3834848
cn11
Allelic
Composition
Atrxtm1Rjg/Y
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (75 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• pericellular varicosities in the retina are significantly reduced compared to in wild-type mice indicating a disturbance in the dopaminergic network
• between P10 and P17, mice exhibit a loss of amacrine cells
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice
• however, embryonic development of amacrine cells is normal
• loss of horizontal cells after P5
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas
• cellularity is reduced 15% while the number of ganglion cells is normal
• cellularity is reduced 25% with the numbers of Muller, bipolar and photoreceptor cells are normal
• the b-wave is reduced 30% at the five highest light intensities tested compared to in wild-type mice
• oscillatory potentials are reduced in amplitude at multiple light intensities compared to in wild-type mice
• however, the a-wave is normal

nervous system
• between P10 and P17, mice exhibit a loss of amacrine cells
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice
• however, embryonic development of amacrine cells is normal
• loss of horizontal cells after P5
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas




Genotype
MGI:5705505
cn12
Allelic
Composition
Kdrtm2Sato/Kdrtm2Sato
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm2Sato mutation (1 available); any Kdr mutation (34 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
Vegfatm2Gne mutation (0 available); any Vegfa mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• some arteriovenous crossings is observed
• however, mice do not exhibit early vertical vascular branching in the retina observed in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice

vision/eye
• some arteriovenous crossings is observed
• however, mice do not exhibit early vertical vascular branching in the retina observed in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice




Genotype
MGI:3835510
cn13
Allelic
Composition
Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+
Ngfrtm1Klee/Ngfrtm1Klee
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(GAP43)Gld mutation (0 available); any Gt(ROSA)26Sor mutation (310 available)
Ngfrtm1Klee mutation (0 available); any Ngfr mutation (13 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice

vision/eye
N
• retinal development, size, and patterning are normal
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice




Genotype
MGI:5705503
cn14
Allelic
Composition
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (13 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (72 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (34 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected

vision/eye
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice
• however, no misdirected angiogenesis is detected




Genotype
MGI:5705499
cn15
Allelic
Composition
Kdrtm1Ykub/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Ykub mutation (0 available); any Kdr mutation (34 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (34 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no misdirected angiogenesis is detected in the retina

vision/eye
N
• no misdirected angiogenesis is detected in the retina




Genotype
MGI:5705500
cn16
Allelic
Composition
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (34 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice
• misdirected vascular growth
• at P9, deep and intermediate plexuses have already formed unlike in control mice
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice
• however, no additional angiogenesis is observed

vision/eye
N
• retinas exhibit normal neuronal thickness, morphology, proliferation and survival and vertical sprouts extend between normal ganglion cells
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice
• misdirected vascular growth
• at P9, deep and intermediate plexuses have already formed unlike in control mice
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice
• however, no additional angiogenesis is observed




Genotype
MGI:4821787
cn17
Allelic
Composition
Pax6tm2Pgr/Pax6+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (54 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice exhibit no defects in the iridocorneal angle, trabecular meshwork and Schlemm's canal
• the stroma of the iris is thinner




Genotype
MGI:5544088
cn18
Allelic
Composition
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Spatially localized Edn2 expression results in local inhibition of retinal vascular development in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pax6-cre,GFP)2Pgr/0 mice

vision/eye
• regional thinning of all three layers in the peripheral retina
• intraretinal capillaries are rarely seen in the peripheral retina
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina
• in the peripheral retina
• in the peripheral retina
• in the peripheral retina

homeostasis/metabolism
• in the peripheral retina

cardiovascular system
• intraretinal capillaries are rarely seen in the peripheral retina
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina




Genotype
MGI:5305027
cn19
Allelic
Composition
Dscamtm1Pfu/Dscamtm1Pfu
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (0 available); any Dscam mutation (42 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dopaminergic amacrine cells and neurites are clumped
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina

nervous system
• of retinal dopaminergic and bNOS positive amacrine cell neurites
• dopaminergic amacrine cells and neurites are clumped
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina

cellular
• of retinal dopaminergic and bNOS positive amacrine cell neurites




Genotype
MGI:5544090
cn20
Allelic
Composition
Ednrbtm1.1Nat/Ednrbtm1.2Nat
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1.1Nat mutation (1 available); any Ednrb mutation (72 available)
Ednrbtm1.2Nat mutation (0 available); any Ednrb mutation (72 available)
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination

cardiovascular system
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination




Genotype
MGI:5705502
cn21
Allelic
Composition
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (13 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (72 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice

vision/eye
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice
• insufficient separation of the inner and outer nuclear layers with fewer Pax6+ cells




Genotype
MGI:3707433
cn22
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (59 available)
Rbl1tm1Tyj mutation (1 available); any Rbl1 mutation (36 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in 61% of mice visible unilateral retinoblastoma develop with delayed and variable kinetics appearing on average by 208 +/- 17 days relative to mice lacking Rbl2
• unlike mice lacking Rbl2, bilateral visible retinoblastomas are rare
• however, 3 of 11 retinas from mice with unilateral tumors in the opposite eye contain early retinoblastomas with mitotic figures and Homer-Wright rosettes
• at P60 4 of 14 eyes have retinoblastomas at level of the optic nerve head in the extreme periphery of the retina

vision/eye
• in 61% of mice visible unilateral retinoblastoma develop with delayed and variable kinetics appearing on average by 208 +/- 17 days relative to mice lacking Rbl2
• unlike mice lacking Rbl2, bilateral visible retinoblastomas are rare
• however, 3 of 11 retinas from mice with unilateral tumors in the opposite eye contain early retinoblastomas with mitotic figures and Homer-Wright rosettes
• at P60 4 of 14 eyes have retinoblastomas at level of the optic nerve head in the extreme periphery of the retina
• in 11 of 11 mice with unilateral tumors, the retina in the tumor free eye is disorganized and degenerated
• at P31 6 of 24 retinas have dysplastic lesions containing Homer-Wright rosettes at the level of the optic nerve in the extreme periphery and increased proliferation in the periphery without histological evidence of retinoblastoma

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinoblastoma; RB1 180200 J:119919




Genotype
MGI:5705504
cn23
Allelic
Composition
Vhltm1Jae/Vhltm1Jae
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
Vhltm1Jae mutation (2 available); any Vhl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• early vertical branching from primary vascular plexuses in the retina

vision/eye
• early vertical branching from primary vascular plexuses in the retina




Genotype
MGI:3821863
cn24
Allelic
Composition
Pcdhgtm2Xzw/Pcdhgtm2Xzw
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhgtm2Xzw mutation (1 available); any Pcdhg mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• despite the reduction in several retinal cell types, the numbers of horizontal cells, photoreceptors and synapses in the inner plexiform layer are normal
• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice

nervous system
• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice




Genotype
MGI:3625926
cn25
Allelic
Composition
Sox2tm1Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm1Lpev mutation (1 available); any Sox2 mutation (31 available)
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (31 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• a further reduction in eye size at E14.5 compared to Sox2tm1Lpev/Sox2tm3Lpev or Sox2tm1Lpev/Sox2tm4Lpev hypomorphs




Genotype
MGI:3713886
cn26
Allelic
Composition
Sox2tm2Lpev/Sox2tm2.1Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm2.1Lpev mutation (0 available); any Sox2 mutation (31 available)
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (31 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at E13.5, retinas are significantly smaller than Sox2tm2Lpev Tg(Pax6-cre,GFP)2Pgr heterozygotes
• retinal proliferation is reduced and differentiation marked by Math5, NeuroD, and beta-TubulinIII staining is absent




Genotype
MGI:3625927
cn27
Allelic
Composition
Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (31 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the loss of general retinal progenitor cell characteristics as determined by retinal differentiation makers
• retinas are significantly smaller in size compared with Sox2tm2Lpev/Sox2+ with a transgene control note: marked reduction of cell proliferation in the distal retina by E13.5




Genotype
MGI:3707434
cn28
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (59 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• increased apoptosis is seen
• at P12 extensive cell proliferation occurs
• however, by P21 proliferation is no longer detected unlike in mice that also lack Rbl2

cellular
• increased apoptosis is seen




Genotype
MGI:3707432
cn29
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (59 available)
Rbl2tm2.1Tyj mutation (0 available); any Rbl2 mutation (18 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are moribund by 183 +/- 39 days

neoplasm
• visible bilateral retinoblastoma develop with rapid and consistent kinetics appearing on average at 128 +/- 18 days
• amacrine cells, a subset of progenitor cells, and Muller cells are present in tumors
• at P31 (4 animals) and P60 (3 animals) large tumors are present and all mice have retinoblastomas in each eye that seed the vitreous and anterior chamber by 4 months of age
• by 183 +/- 39 days mice have grossly distended eyes where the tumor has filled the anterior chambers and often invaded of local tissues
• tumors infiltrate the optic nerve and metastases are found in the cervical lymph nodes (11 of 28) and brain (7 of 27)

vision/eye
• at P12, apoptosis is increased and at P21 retinas contain apoptotic bodies
• the increase in apoptosis is greater than in mutant mice wild-type for Rbl2
• visible bilateral retinoblastoma develop with rapid and consistent kinetics appearing on average at 128 +/- 18 days
• amacrine cells, a subset of progenitor cells, and Muller cells are present in tumors
• at P31 (4 animals) and P60 (3 animals) large tumors are present and all mice have retinoblastomas in each eye that seed the vitreous and anterior chamber by 4 months of age
• by 183 +/- 39 days mice have grossly distended eyes where the tumor has filled the anterior chambers and often invaded of local tissues
• tumors infiltrate the optic nerve and metastases are found in the cervical lymph nodes (11 of 28) and brain (7 of 27)
• at P12 in the retinal periphery proliferation and apoptosis are increased and proliferation remains elevated at P21,especially in the extreme periphery
• proliferation is increased and prolonged relative to mutant mice wild-type for Rbl2
• at P21 retinas are very hypocellular, contain apoptotic bodies and many cells with large and/or irregular-shaped nuclei, and 9 of 12 have early dysplatic lesions containing Homer-Wright rosettes in the extreme periphery
• at P21, the amacrine layer is significantly reduced away from tumor areas
• increase in horizontal cells in contrast to the general hypocellularity of the retina
• rod bipolar cells are very rare or absent from retinas and retinoblastomas
• at P21, the three nuclear layers can not be distinguished, except in the central retina where Cre expression is reduced
• Tuji-positive retinal ganglion cells are very rare or completely absent from retinas and tumors
• a cone subset (positive for M-opsin) is very rare or absent from retinas and retinoblastomas
• despite the increase in proliferation retinas are very hypoplastic at P21

nervous system
• Tuji-positive retinal ganglion cells are very rare or completely absent from retinas and tumors
• a cone subset (positive for M-opsin) is very rare or absent from retinas and retinoblastomas
• at P21, the amacrine layer is significantly reduced away from tumor areas
• increase in horizontal cells in contrast to the general hypocellularity of the retina
• rod bipolar cells are very rare or absent from retinas and retinoblastomas

cellular
• at P12, apoptosis is increased and at P21 retinas contain apoptotic bodies
• the increase in apoptosis is greater than in mutant mice wild-type for Rbl2

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinoblastoma; RB1 180200 J:119919




Genotype
MGI:3783526
cn30
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (59 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• extensive at P4 and P12
• ectopic S-phase and mitotic activity are detected unlike in wild-type mice throughout the entire retina
• at E18.5, in the retinal ganglion cell layer
• some inner cell layer cells are very large and of horizontal cell lineage

nervous system
• in the retina at 3 weeks of age
• at E18.5, in the retinal ganglion cell layer

cellular
• extensive at P4 and P12




Genotype
MGI:5567086
cn31
Allelic
Composition
Pax6tm1.1Zkoz/Pax6tm1.1Zkoz
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm1.1Zkoz mutation (0 available); any Pax6 mutation (54 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• expanded amacrine cell population in distal retinal layers in adult retinal sections




Genotype
MGI:3842430
cx32
Allelic
Composition
Pou4f2tm1Nat/Pou4f2tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f2tm1Nat mutation (0 available); any Pou4f2 mutation (1 available)
Pou4f2tm2.1Nat mutation (1 available); any Pou4f2 mutation (1 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• retinal ganglion cells (RGC) have larger surface area and thick arbors
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data
• a small percentage of RGC lack axons
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing
• 70% of retinal ganglion cells are not present

nervous system
• large decrements in RGC projections occur to the nucleus adjacent to the optic tract compared to controls
• the accessory optic tract is missing
• numerous neurites emerge at P4 from the optic tract and penetrate nearby nontarget areas
• large decrements in RGC projections occur to this part of the brain compared to controls
• large decrements in RGC projections occur to this part of the brain compared to controls
• retinal ganglion cells (RGC) have larger surface area and thick arbors
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data
• a small percentage of RGC lack axons
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing
• 70% of retinal ganglion cells are not present





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory