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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pax6-cre,GFP)2Pgr
transgene insertion 2, Peter Gruss
MGI:3052661
Summary 32 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 MGI:5705506
cn2
Pou4f1tm1Nat/Pou4f1tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 * 129S7/SvEvBrd MGI:3842429
cn3
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 * C57BL/6 * FVB/N MGI:4437797
cn4
E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722927
cn5
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722928
cn6
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Nphp1tm1Jgg/Nphp1+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:4437798
cn7
E2f2tm1Zubi/E2f2tm1Zubi
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722916
cn8
E2f1tm1Meg/E2f1+
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722917
cn9
E2f1tm1Meg/E2f1tm1Meg
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722918
cn10
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129 * C57BL/6 * FVB/N * NMRI MGI:3722920
cn11
Atrxtm1Rjg/Y
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3834848
cn12
Kdrtm2Sato/Kdrtm2Sato
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv MGI:5705505
cn13
Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+
Ngfrtm1Klee/Ngfrtm1Klee
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv MGI:3835510
cn14
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 MGI:5705503
cn15
Kdrtm1Ykub/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ MGI:5705499
cn16
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ MGI:5705500
cn17
Pax6tm2Pgr/Pax6+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ MGI:4821787
cn18
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5544088
cn19
Dscamtm1Pfu/Dscamtm1Pfu
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5305027
cn20
Ednrbtm1.1Nat/Ednrbtm1.2Nat
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5544090
cn21
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S1/SvImJ * C57BL/6 MGI:5705502
cn22
Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N MGI:3707433
cn23
Vhltm1Jae/Vhltm1Jae
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S4/SvJae MGI:5705504
cn24
Pcdhgtm2Xzw/Pcdhgtm2Xzw
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S7/SvEvBrd * C57BL/6J MGI:3821863
cn25
Sox2tm1Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv MGI:3625926
cn26
Sox2tm2Lpev/Sox2tm2.1Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv MGI:3713886
cn27
Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S/SvEv MGI:3625927
cn28
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3707434
cn29
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3707432
cn30
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Not Specified MGI:3783526
cn31
Pax6tm1.1Zkoz/Pax6tm1.1Zkoz
Tg(Pax6-cre,GFP)2Pgr/0
Not Specified MGI:5567086
cx32
Pou4f2tm1Nat/Pou4f2tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S7/SvEvBrd MGI:3842430


Genotype
MGI:5705506
cn1
Allelic
Composition
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
Vegfatm2Gne mutation (0 available); any Vegfa mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• some arteriovenous crossings is observed (J:217533)
• some arteriovenous crossings is observed (J:217533)

vision/eye
• some arteriovenous crossings is observed (J:217533)
• some arteriovenous crossings is observed (J:217533)




Genotype
MGI:3842429
cn2
Allelic
Composition
Pou4f1tm1Nat/Pou4f1tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129 * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1Nat mutation (0 available); any Pou4f1 mutation (2 available)
Pou4f1tm2.1Nat mutation (1 available); any Pou4f1 mutation (2 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice (J:147350)
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes (J:147350)
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated (J:147350)
• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice (J:147350)
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes (J:147350)
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated (J:147350)

vision/eye
• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice (J:147350)
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes (J:147350)
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated (J:147350)
• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice (J:147350)
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes (J:147350)
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated (J:147350)




Genotype
MGI:4437797
cn3
Allelic
Composition
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (13 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (13 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:3722927
cn4
Allelic
Composition
E2f1tm1Meg/E2f1tm1Meg
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (4 available)
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (13 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• bipolar and ganglion cell death, starburst amacrine cell (SAC) differentiation, and SAC track disorder observed in Rbl1 null, Rbl1/E2f3 null or Rbl1/E2f1 null mice are rescued (J:124204)
• bipolar and ganglion cell death, starburst amacrine cell (SAC) differentiation, and SAC track disorder observed in Rbl1 null, Rbl1/E2f3 null or Rbl1/E2f1 null mice are rescued (J:124204)




Genotype
MGI:3722928
cn5
Allelic
Composition
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the optic nerve is thin due to the loss of retinal ganglion cells (J:124204)
• the optic nerve is thin due to the loss of retinal ganglion cells (J:124204)
• retinal transition (RTC) undergo ectopic DNA synthesis and increased apoptosis (J:124204)
• at P8 or P18 when cell division is completed in the wild-type retina, ectopic RTC divisions are detected (J:124204)
• retinal transition (RTC) undergo ectopic DNA synthesis and increased apoptosis (J:124204)
• at P8 or P18 when cell division is completed in the wild-type retina, ectopic RTC divisions are detected (J:124204)
• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina (J:124204)
• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina (J:124204)
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• however, SAC survival and process outgrowth is normal (J:124204)
• as markers of differentiation are detected early in the cell body if at all, synthesis or stability and transport of SAC markers is defective (J:124204)
• 5.6% of Camk2+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 3.7% in Rbl1/E2f1 null mice and 91% in Rbl1/E2f3 null mice (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• however, SAC survival and process outgrowth is normal (J:124204)
• as markers of differentiation are detected early in the cell body if at all, synthesis or stability and transport of SAC markers is defective (J:124204)
• 5.6% of Camk2+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 3.7% in Rbl1/E2f1 null mice and 91% in Rbl1/E2f3 null mice (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• after P8, mice exhibit a reduction in Callb2+ starburst amacrine ccell bodies, indicative of amacrine cells (J:124204)
• after P8, mice exhibit a reduction in Callb2+ starburst amacrine ccell bodies, indicative of amacrine cells (J:124204)
• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• the outer nuclear layer is thin due to the loss of rods (J:124204)
• the outer nuclear layer is thin due to the loss of rods (J:124204)
• light-adapted (photopic) response is defective (J:124204)
• light-adapted (photopic) response is defective (J:124204)
• the response to dim light in dark-adapted (scotopic) conditions is defective (J:124204)
• the response to dim light in dark-adapted (scotopic) conditions is defective (J:124204)

nervous system
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• however, SAC survival and process outgrowth is normal (J:124204)
• as markers of differentiation are detected early in the cell body if at all, synthesis or stability and transport of SAC markers is defective (J:124204)
• 5.6% of Camk2+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 3.7% in Rbl1/E2f1 null mice and 91% in Rbl1/E2f3 null mice (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• however, SAC survival and process outgrowth is normal (J:124204)
• as markers of differentiation are detected early in the cell body if at all, synthesis or stability and transport of SAC markers is defective (J:124204)
• 5.6% of Camk2+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 3.7% in Rbl1/E2f1 null mice and 91% in Rbl1/E2f3 null mice (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• the optic nerve is thin due to the loss of retinal ganglion cells (J:124204)
• the optic nerve is thin due to the loss of retinal ganglion cells (J:124204)




Genotype
MGI:4437798
cn6
Allelic
Composition
Ahi1tm1Jgg/Ahi1tm2.1Jgg
Nphp1tm1Jgg/Nphp1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (13 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (13 available)
Nphp1tm1Jgg mutation (1 available); any Nphp1 mutation (6 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:3722916
cn7
Allelic
Composition
E2f2tm1Zubi/E2f2tm1Zubi
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f2tm1Zubi mutation (1 available); any E2f2 mutation (12 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates many rod cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates many rod cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates most bipolar cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates most bipolar cells as in Rbl1 null mice (J:124204)
• retinal transition cells (RTC) undergo ectopic cell divisions as in Rbl1 null mice (J:124204)
• retinal transition cells (RTC) undergo ectopic cell divisions as in Rbl1 null mice (J:124204)

nervous system
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates most retinal ganglion cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates many rod cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates many rod cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates most bipolar cells as in Rbl1 null mice (J:124204)
• apoptosis eliminates most bipolar cells as in Rbl1 null mice (J:124204)




Genotype
MGI:3722917
cn8
Allelic
Composition
E2f1tm1Meg/E2f1+
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (4 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• ectopic retinal transition cell division observed in Rbl1 null mice is partially suppressed (J:124204)
• ectopic retinal transition cell division observed in Rbl1 null mice is partially suppressed (J:124204)




Genotype
MGI:3722918
cn9
Allelic
Composition
E2f1tm1Meg/E2f1tm1Meg
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1tm1Meg mutation (2 available); any E2f1 mutation (4 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina (J:124204)
• however, retinal transition cell division, rod cell numbers, retinal differentiation and rod function are normal (J:124204)
• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina (J:124204)
• however, retinal transition cell division, rod cell numbers, retinal differentiation and rod function are normal (J:124204)
• mice have slightly fewer ganglion cells at P0 (J:124204)
• mice have slightly fewer ganglion cells at P0 (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice (J:124204)
• mice have slightly fewer bipolar cells at P18 or P30 (J:124204)
• however, the proportion of bipolar cells is normal (J:124204)
• mice have slightly fewer bipolar cells at P18 or P30 (J:124204)
• however, the proportion of bipolar cells is normal (J:124204)
• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• the retinal outer nuclear layer is slightly reduced in thickness at P18 or P30 (J:124204)
• the retinal outer nuclear layer is slightly reduced in thickness at P18 or P30 (J:124204)
• photopic response is very slightly reduced (J:124204)
• photopic response is very slightly reduced (J:124204)

nervous system
• mice have slightly fewer ganglion cells at P0 (J:124204)
• mice have slightly fewer ganglion cells at P0 (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice (J:124204)
• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis (J:124204)
• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer (J:124204)
• Slc18a3 staining of mature SACs is absent from the peripheral retina (J:124204)
• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice (J:124204)
• mice have slightly fewer bipolar cells at P18 or P30 (J:124204)
• however, the proportion of bipolar cells is normal (J:124204)
• mice have slightly fewer bipolar cells at P18 or P30 (J:124204)
• however, the proportion of bipolar cells is normal (J:124204)




Genotype
MGI:3722920
cn10
Allelic
Composition
E2f3tm1.1Gle/E2f3tm1.1Gle
Rbl1tm1Htr/Rbl1tm1Htr
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f3tm1.1Gle mutation (0 available); any E2f3 mutation (13 available)
Rbl1tm1Htr mutation (0 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells (J:124204)
• however, markers of SAC differentiation are restored (J:124204)
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis (J:124204)
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells (J:124204)
• however, markers of SAC differentiation are restored (J:124204)
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• retinal transition cells (RTC) undergo ectopic cell divisions (J:124204)
• however, markers of starburst amacrine cell differentiation are restored (J:124204)
• retinal transition cells (RTC) undergo ectopic cell divisions (J:124204)
• however, markers of starburst amacrine cell differentiation are restored (J:124204)

nervous system
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates most retinal ganglion cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• apoptosis eliminates many rod cells (J:124204)
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells (J:124204)
• however, markers of SAC differentiation are restored (J:124204)
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis (J:124204)
• while present, starburst amacrine cell (SAC) tracks are slightly disordered due to a lack of synaptic partner cells (J:124204)
• however, markers of SAC differentiation are restored (J:124204)
• 91% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 3.7% in Rb/E2f1 null mice due to the presence of Camk2a+ ganglion cells that would normally be killed by apoptosis (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)
• apoptosis eliminates most bipolar cells (J:124204)




Genotype
MGI:3834848
cn11
Allelic
Composition
Atrxtm1Rjg/Y
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrxtm1Rjg mutation (0 available); any Atrx mutation (72 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• pericellular varicosities in the retina are significantly reduced compared to in wild-type mice indicating a disturbance in the dopaminergic network (J:145002)
• pericellular varicosities in the retina are significantly reduced compared to in wild-type mice indicating a disturbance in the dopaminergic network (J:145002)
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)
• cellularity is reduced 15% while the number of ganglion cells is normal (J:145002)
• cellularity is reduced 15% while the number of ganglion cells is normal (J:145002)
• cellularity is reduced 25% with the numbers of Muller, bipolar and photoreceptor cells are normal (J:145002)
• cellularity is reduced 25% with the numbers of Muller, bipolar and photoreceptor cells are normal (J:145002)
• the b-wave is reduced 30% at the five highest light intensities tested compared to in wild-type mice (J:145002)
• oscillatory potentials are reduced in amplitude at multiple light intensities compared to in wild-type mice (J:145002)
• however, the a-wave is normal (J:145002)
• the b-wave is reduced 30% at the five highest light intensities tested compared to in wild-type mice (J:145002)
• oscillatory potentials are reduced in amplitude at multiple light intensities compared to in wild-type mice (J:145002)
• however, the a-wave is normal (J:145002)

nervous system
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• between P10 and P17, mice exhibit a loss of amacrine cells (J:145002)
• adult mice exhibit a 34% reduction in the number of amacrine cells found in the peripheral retina compared to in wild-type mice (J:145002)
• mice exhibit a reduction in the number of multiple subtypes of amacrine neurons compared to in wild-type mice (J:145002)
• however, embryonic development of amacrine cells is normal (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)
• loss of horizontal cells after P5 (J:145002)
• adult mice exhibit a 37% decrease in horizontal cells compared to in wild-type retinas (J:145002)




Genotype
MGI:5705505
cn12
Allelic
Composition
Kdrtm2Sato/Kdrtm2Sato
Vegfatm2Gne/Vegfatm2Gne
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm2Sato mutation (1 available); any Kdr mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
Vegfatm2Gne mutation (0 available); any Vegfa mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• some arteriovenous crossings is observed (J:217533)
• however, mice do not exhibit early vertical vascular branching in the retina observed in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• some arteriovenous crossings is observed (J:217533)
• however, mice do not exhibit early vertical vascular branching in the retina observed in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)

vision/eye
• some arteriovenous crossings is observed (J:217533)
• however, mice do not exhibit early vertical vascular branching in the retina observed in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• some arteriovenous crossings is observed (J:217533)
• however, mice do not exhibit early vertical vascular branching in the retina observed in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)




Genotype
MGI:3835510
cn13
Allelic
Composition
Gt(ROSA)26Sortm1(GAP43)Gld/Gt(ROSA)26Sor+
Ngfrtm1Klee/Ngfrtm1Klee
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(GAP43)Gld mutation (0 available); any Gt(ROSA)26Sor mutation (305 available)
Ngfrtm1Klee mutation (0 available); any Ngfr mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice (J:145459)
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice (J:145459)
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice (J:145459)
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice (J:145459)

vision/eye
N
• retinal development, size, and patterning are normal (J:145459)
• retinal development, size, and patterning are normal (J:145459)
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice (J:145459)
• the nasal domain of retinal axon termination zone is expanded anteriorly compared to in wild-type mice (J:145459)




Genotype
MGI:5705503
cn14
Allelic
Composition
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (4 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (59 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• however, no misdirected angiogenesis is detected (J:217533)
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• however, no misdirected angiogenesis is detected (J:217533)

vision/eye
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• however, no misdirected angiogenesis is detected (J:217533)
• abnormal superficial plexus as in Dnm1tm2.1Pdc/Dnm1tm2.1Pdc Dnm2tm1.1Pdc/Dnm2tm1.1Pdc Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• however, no misdirected angiogenesis is detected (J:217533)




Genotype
MGI:5705499
cn15
Allelic
Composition
Kdrtm1Ykub/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Ykub mutation (0 available); any Kdr mutation (12 available)
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no misdirected angiogenesis is detected in the retina (J:217533)
• no misdirected angiogenesis is detected in the retina (J:217533)

vision/eye
N
• no misdirected angiogenesis is detected in the retina (J:217533)
• no misdirected angiogenesis is detected in the retina (J:217533)




Genotype
MGI:5705500
cn16
Allelic
Composition
Kdrtm2.1Jrt/Kdrtm2.1Jrt
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm2.1Jrt mutation (2 available); any Kdr mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina (J:217533)
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice (J:217533)
• misdirected vascular growth (J:217533)
• at P9, deep and intermediate plexuses have already formed unlike in control mice (J:217533)
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice (J:217533)
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice (J:217533)
• however, no additional angiogenesis is observed (J:217533)
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina (J:217533)
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice (J:217533)
• misdirected vascular growth (J:217533)
• at P9, deep and intermediate plexuses have already formed unlike in control mice (J:217533)
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice (J:217533)
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice (J:217533)
• however, no additional angiogenesis is observed (J:217533)

vision/eye
N
• retinas exhibit normal neuronal thickness, morphology, proliferation and survival and vertical sprouts extend between normal ganglion cells (J:217533)
• retinas exhibit normal neuronal thickness, morphology, proliferation and survival and vertical sprouts extend between normal ganglion cells (J:217533)
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina (J:217533)
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice (J:217533)
• misdirected vascular growth (J:217533)
• at P9, deep and intermediate plexuses have already formed unlike in control mice (J:217533)
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice (J:217533)
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice (J:217533)
• however, no additional angiogenesis is observed (J:217533)
• ragged and caved edges in vascular fronts with persistent hyaloid vessels and slight delay in radial growth in the retina (J:217533)
• at P6, mice show abundant vertical branching into the neuroblastic layers unlike in control mice (J:217533)
• misdirected vascular growth (J:217533)
• at P9, deep and intermediate plexuses have already formed unlike in control mice (J:217533)
• at P28, mice exhibit increased vessel branching in intermediate and deep plexuses compared with control mice (J:217533)
• mice exhibit decreased regenerative angiogenesis that does not progress to deep layers with abnormal vessels growing into intra-capillary spaces compared with control mice (J:217533)
• however, no additional angiogenesis is observed (J:217533)




Genotype
MGI:4821787
cn17
Allelic
Composition
Pax6tm2Pgr/Pax6+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (49 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice exhibit no defects in the iridocorneal angle, trabecular meshwork and Schlemm's canal (J:163191)
• mice exhibit no defects in the iridocorneal angle, trabecular meshwork and Schlemm's canal (J:163191)
• the stroma of the iris is thinner (J:163191)
• the stroma of the iris is thinner (J:163191)




Genotype
MGI:5544088
cn18
Allelic
Composition
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Spatially localized Edn2 expression results in local inhibition of retinal vascular development in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pax6-cre,GFP)2Pgr/0 mice

vision/eye
• regional thinning of all three layers in the peripheral retina (J:201133)
• regional thinning of all three layers in the peripheral retina (J:201133)
• intraretinal capillaries are rarely seen in the peripheral retina (J:201133)
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina (J:201133)
• intraretinal capillaries are rarely seen in the peripheral retina (J:201133)
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina (J:201133)
• in the peripheral retina (J:201133)
• in the peripheral retina (J:201133)
• in the peripheral retina (J:201133)
• in the peripheral retina (J:201133)
• in the peripheral retina (J:201133)
• in the peripheral retina (J:201133)

homeostasis/metabolism
• in the peripheral retina (J:201133)
• in the peripheral retina (J:201133)

cardiovascular system
• intraretinal capillaries are rarely seen in the peripheral retina (J:201133)
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina (J:201133)
• intraretinal capillaries are rarely seen in the peripheral retina (J:201133)
• numerous filopodia-bearing endothelial cells are seen at the boundary between the vascularized central retina and the nearly avascular peripheral retina (J:201133)




Genotype
MGI:5305027
cn19
Allelic
Composition
Dscamtm1Pfu/Dscamtm1Pfu
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (0 available); any Dscam mutation (6 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dopaminergic amacrine cells and neurites are clumped (J:179393)
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive (J:179393)
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons (J:179393)
• dopaminergic amacrine cells and neurites are clumped (J:179393)
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive (J:179393)
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons (J:179393)
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina (J:179393)
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina (J:179393)

nervous system
• of retinal dopaminergic and bNOS positive amacrine cell neurites (J:179393)
• of retinal dopaminergic and bNOS positive amacrine cell neurites (J:179393)
• dopaminergic amacrine cells and neurites are clumped (J:179393)
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive (J:179393)
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons (J:179393)
• dopaminergic amacrine cells and neurites are clumped (J:179393)
• disorganization is seen in all portions of the inner nuclear layer, even where cre is inactive (J:179393)
• cholinergic amacrine cell lamination is impaired in portions of the retina where cre is active in all retinal neurons (J:179393)
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina (J:179393)
• melanopsin-positive RGCs are fasciculated and aggregated in the peripheral retina, but not in the central or dorsal retina (J:179393)

cellular
• of retinal dopaminergic and bNOS positive amacrine cell neurites (J:179393)
• of retinal dopaminergic and bNOS positive amacrine cell neurites (J:179393)




Genotype
MGI:5544090
cn20
Allelic
Composition
Ednrbtm1.1Nat/Ednrbtm1.2Nat
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1.1Nat mutation (1 available); any Ednrb mutation (61 available)
Ednrbtm1.2Nat mutation (0 available); any Ednrb mutation (61 available)
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination (J:201133)
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination (J:201133)

cardiovascular system
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination (J:201133)
• removal of Ednrb appears to sensitize the vasculature as growth arrests proximal to the front of cre-mediated recombination (J:201133)




Genotype
MGI:5705502
cn21
Allelic
Composition
Dnm1tm2.1Pdc/Dnm1tm2.1Pdc
Dnm2tm1.1Pdc/Dnm2tm1.1Pdc
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1tm2.1Pdc mutation (1 available); any Dnm1 mutation (4 available)
Dnm2tm1.1Pdc mutation (1 available); any Dnm2 mutation (59 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)

vision/eye
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• superficial plexus is more severely impaired than in Kdrtm2.1Jrt/Kdrtm2.1Jrt Tg(Pax6-cre,GFP)2Pgr mice (J:217533)
• insufficient separation of the inner and outer nuclear layers with fewer Pax6+ cells (J:217533)
• insufficient separation of the inner and outer nuclear layers with fewer Pax6+ cells (J:217533)




Genotype
MGI:3707433
cn22
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Rbl1tm1Tyj/Rbl1tm1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (34 available)
Rbl1tm1Tyj mutation (1 available); any Rbl1 mutation (12 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• in 61% of mice visible unilateral retinoblastoma develop with delayed and variable kinetics appearing on average by 208 +/- 17 days relative to mice lacking Rbl2 (J:119919)
• unlike mice lacking Rbl2, bilateral visible retinoblastomas are rare (J:119919)
• however, 3 of 11 retinas from mice with unilateral tumors in the opposite eye contain early retinoblastomas with mitotic figures and Homer-Wright rosettes (J:119919)
• at P60 4 of 14 eyes have retinoblastomas at level of the optic nerve head in the extreme periphery of the retina (J:119919)
• in 61% of mice visible unilateral retinoblastoma develop with delayed and variable kinetics appearing on average by 208 +/- 17 days relative to mice lacking Rbl2 (J:119919)
• unlike mice lacking Rbl2, bilateral visible retinoblastomas are rare (J:119919)
• however, 3 of 11 retinas from mice with unilateral tumors in the opposite eye contain early retinoblastomas with mitotic figures and Homer-Wright rosettes (J:119919)
• at P60 4 of 14 eyes have retinoblastomas at level of the optic nerve head in the extreme periphery of the retina (J:119919)

vision/eye
• in 11 of 11 mice with unilateral tumors, the retina in the tumor free eye is disorganized and degenerated (J:119919)
• at P31 6 of 24 retinas have dysplastic lesions containing Homer-Wright rosettes at the level of the optic nerve in the extreme periphery and increased proliferation in the periphery without histological evidence of retinoblastoma (J:119919)
• in 11 of 11 mice with unilateral tumors, the retina in the tumor free eye is disorganized and degenerated (J:119919)
• at P31 6 of 24 retinas have dysplastic lesions containing Homer-Wright rosettes at the level of the optic nerve in the extreme periphery and increased proliferation in the periphery without histological evidence of retinoblastoma (J:119919)

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinoblastoma; RB1 180200 J:119919




Genotype
MGI:5705504
cn23
Allelic
Composition
Vhltm1Jae/Vhltm1Jae
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
Vhltm1Jae mutation (2 available); any Vhl mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• early vertical branching from primary vascular plexuses in the retina (J:217533)
• early vertical branching from primary vascular plexuses in the retina (J:217533)

vision/eye
• early vertical branching from primary vascular plexuses in the retina (J:217533)
• early vertical branching from primary vascular plexuses in the retina (J:217533)




Genotype
MGI:3821863
cn24
Allelic
Composition
Pcdhgtm2Xzw/Pcdhgtm2Xzw
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhgtm2Xzw mutation (1 available); any Pcdhg mutation (10 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• despite the reduction in several retinal cell types, the numbers of horizontal cells, photoreceptors and synapses in the inner plexiform layer are normal (J:142186)
• despite the reduction in several retinal cell types, the numbers of horizontal cells, photoreceptors and synapses in the inner plexiform layer are normal (J:142186)
• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice (J:142186)
• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)

nervous system
• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice (J:142186)
• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)
• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice (J:142186)




Genotype
MGI:3625926
cn25
Allelic
Composition
Sox2tm1Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm1Lpev mutation (1 available); any Sox2 mutation (25 available)
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (25 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• a further reduction in eye size at E14.5 compared to Sox2tm1Lpev/Sox2tm3Lpev or Sox2tm1Lpev/Sox2tm4Lpev hypomorphs (J:108452)
• a further reduction in eye size at E14.5 compared to Sox2tm1Lpev/Sox2tm3Lpev or Sox2tm1Lpev/Sox2tm4Lpev hypomorphs (J:108452)




Genotype
MGI:3713886
cn26
Allelic
Composition
Sox2tm2Lpev/Sox2tm2.1Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm2.1Lpev mutation (0 available); any Sox2 mutation (25 available)
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (25 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at E13.5, retinas are significantly smaller than Sox2tm2Lpev Tg(Pax6-cre,GFP)2Pgr heterozygotes (J:108452)
• retinal proliferation is reduced and differentiation marked by Math5, NeuroD, and beta-TubulinIII staining is absent (J:108452)
• at E13.5, retinas are significantly smaller than Sox2tm2Lpev Tg(Pax6-cre,GFP)2Pgr heterozygotes (J:108452)
• retinal proliferation is reduced and differentiation marked by Math5, NeuroD, and beta-TubulinIII staining is absent (J:108452)




Genotype
MGI:3625927
cn27
Allelic
Composition
Sox2tm2Lpev/Sox2tm2Lpev
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm2Lpev mutation (1 available); any Sox2 mutation (25 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the loss of general retinal progenitor cell characteristics as determined by retinal differentiation makers (J:108452)
• the loss of general retinal progenitor cell characteristics as determined by retinal differentiation makers (J:108452)
• retinas are significantly smaller in size compared with Sox2tm2Lpev/Sox2+ with a transgene control note: marked reduction of cell proliferation in the distal retina by E13.5 (J:108452)
• retinas are significantly smaller in size compared with Sox2tm2Lpev/Sox2+ with a transgene control note: marked reduction of cell proliferation in the distal retina by E13.5 (J:108452)




Genotype
MGI:3707434
cn28
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (34 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• increased apoptosis is seen (J:119919)
• increased apoptosis is seen (J:119919)
• at P12 extensive cell proliferation occurs (J:119919)
• however, by P21 proliferation is no longer detected unlike in mice that also lack Rbl2 (J:119919)
• at P12 extensive cell proliferation occurs (J:119919)
• however, by P21 proliferation is no longer detected unlike in mice that also lack Rbl2 (J:119919)

cellular
• increased apoptosis is seen (J:119919)
• increased apoptosis is seen (J:119919)




Genotype
MGI:3707432
cn29
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2.1Tyj/Rbl2tm2.1Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (34 available)
Rbl2tm2.1Tyj mutation (0 available); any Rbl2 mutation (5 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are moribund by 183 +/- 39 days (J:119919)
• mice are moribund by 183 +/- 39 days (J:119919)

tumorigenesis
• visible bilateral retinoblastoma develop with rapid and consistent kinetics appearing on average at 128 +/- 18 days (J:119919)
• amacrine cells, a subset of progenitor cells, and Muller cells are present in tumors (J:119919)
• at P31 (4 animals) and P60 (3 animals) large tumors are present and all mice have retinoblastomas in each eye that seed the vitreous and anterior chamber by 4 months of age (J:119919)
• by 183 +/- 39 days mice have grossly distended eyes where the tumor has filled the anterior chambers and often invaded of local tissues (J:119919)
• tumors infiltrate the optic nerve and metastases are found in the cervical lymph nodes (11 of 28) and brain (7 of 27) (J:119919)
• visible bilateral retinoblastoma develop with rapid and consistent kinetics appearing on average at 128 +/- 18 days (J:119919)
• amacrine cells, a subset of progenitor cells, and Muller cells are present in tumors (J:119919)
• at P31 (4 animals) and P60 (3 animals) large tumors are present and all mice have retinoblastomas in each eye that seed the vitreous and anterior chamber by 4 months of age (J:119919)
• by 183 +/- 39 days mice have grossly distended eyes where the tumor has filled the anterior chambers and often invaded of local tissues (J:119919)
• tumors infiltrate the optic nerve and metastases are found in the cervical lymph nodes (11 of 28) and brain (7 of 27) (J:119919)

vision/eye
• at P12, apoptosis is increased and at P21 retinas contain apoptotic bodies (J:119919)
• the increase in apoptosis is greater than in mutant mice wild-type for Rbl2 (J:119919)
• at P12, apoptosis is increased and at P21 retinas contain apoptotic bodies (J:119919)
• the increase in apoptosis is greater than in mutant mice wild-type for Rbl2 (J:119919)
• at P12 in the retinal periphery proliferation and apoptosis are increased and proliferation remains elevated at P21,especially in the extreme periphery (J:119919)
• proliferation is increased and prolonged relative to mutant mice wild-type for Rbl2 (J:119919)
• at P21 retinas are very hypocellular, contain apoptotic bodies and many cells with large and/or irregular-shaped nuclei, and 9 of 12 have early dysplatic lesions containing Homer-Wright rosettes in the extreme periphery (J:119919)
• at P12 in the retinal periphery proliferation and apoptosis are increased and proliferation remains elevated at P21,especially in the extreme periphery (J:119919)
• proliferation is increased and prolonged relative to mutant mice wild-type for Rbl2 (J:119919)
• at P21 retinas are very hypocellular, contain apoptotic bodies and many cells with large and/or irregular-shaped nuclei, and 9 of 12 have early dysplatic lesions containing Homer-Wright rosettes in the extreme periphery (J:119919)
• at P21, the amacrine layer is significantly reduced away from tumor areas (J:119919)
• at P21, the amacrine layer is significantly reduced away from tumor areas (J:119919)
• increase in horizontal cells in contrast to the general hypocellularity of the retina (J:119919)
• increase in horizontal cells in contrast to the general hypocellularity of the retina (J:119919)
• rod bipolar cells are very rare or absent from retinas and retinoblastomas (J:119919)
• rod bipolar cells are very rare or absent from retinas and retinoblastomas (J:119919)
• at P21, the three nuclear layers can not be distinguished, except in the central retina where Cre expression is reduced (J:119919)
• at P21, the three nuclear layers can not be distinguished, except in the central retina where Cre expression is reduced (J:119919)
• Tuji-positive retinal ganglion cells are very rare or completely absent from retinas and tumors (J:119919)
• Tuji-positive retinal ganglion cells are very rare or completely absent from retinas and tumors (J:119919)
• a cone subset (positive for M-opsin) is very rare or absent from retinas and retinoblastomas (J:119919)
• a cone subset (positive for M-opsin) is very rare or absent from retinas and retinoblastomas (J:119919)
• despite the increase in proliferation retinas are very hypoplastic at P21 (J:119919)
• despite the increase in proliferation retinas are very hypoplastic at P21 (J:119919)

nervous system
• Tuji-positive retinal ganglion cells are very rare or completely absent from retinas and tumors (J:119919)
• Tuji-positive retinal ganglion cells are very rare or completely absent from retinas and tumors (J:119919)
• a cone subset (positive for M-opsin) is very rare or absent from retinas and retinoblastomas (J:119919)
• a cone subset (positive for M-opsin) is very rare or absent from retinas and retinoblastomas (J:119919)
• at P21, the amacrine layer is significantly reduced away from tumor areas (J:119919)
• at P21, the amacrine layer is significantly reduced away from tumor areas (J:119919)
• increase in horizontal cells in contrast to the general hypocellularity of the retina (J:119919)
• increase in horizontal cells in contrast to the general hypocellularity of the retina (J:119919)
• rod bipolar cells are very rare or absent from retinas and retinoblastomas (J:119919)
• rod bipolar cells are very rare or absent from retinas and retinoblastomas (J:119919)

cellular
• at P12, apoptosis is increased and at P21 retinas contain apoptotic bodies (J:119919)
• the increase in apoptosis is greater than in mutant mice wild-type for Rbl2 (J:119919)
• at P12, apoptosis is increased and at P21 retinas contain apoptotic bodies (J:119919)
• the increase in apoptosis is greater than in mutant mice wild-type for Rbl2 (J:119919)

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinoblastoma; RB1 180200 J:119919




Genotype
MGI:3783526
cn30
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (34 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• extensive at P4 and P12 (J:91406)
• extensive at P4 and P12 (J:91406)
• ectopic S-phase and mitotic activity are detected unlike in wild-type mice throughout the entire retina (J:91406)
• ectopic S-phase and mitotic activity are detected unlike in wild-type mice throughout the entire retina (J:91406)
• at E18.5, in the retinal ganglion cell layer (J:91406)
• at E18.5, in the retinal ganglion cell layer (J:91406)
• some inner cell layer cells are very large and of horizontal cell lineage (J:91406)
• some inner cell layer cells are very large and of horizontal cell lineage (J:91406)
• disorganized (J:91406)
• disorganized (J:91406)

nervous system
• in the retina at 3 weeks of age (J:91406)
• in the retina at 3 weeks of age (J:91406)
• at E18.5, in the retinal ganglion cell layer (J:91406)
• at E18.5, in the retinal ganglion cell layer (J:91406)

cellular
• extensive at P4 and P12 (J:91406)
• extensive at P4 and P12 (J:91406)




Genotype
MGI:5567086
cn31
Allelic
Composition
Pax6tm1.1Zkoz/Pax6tm1.1Zkoz
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm1.1Zkoz mutation (0 available); any Pax6 mutation (49 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• expanded amacrine cell population in distal retinal layers in adult retinal sections (J:208421)
• expanded amacrine cell population in distal retinal layers in adult retinal sections (J:208421)




Genotype
MGI:3842430
cx32
Allelic
Composition
Pou4f2tm1Nat/Pou4f2tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/?
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f2tm1Nat mutation (0 available); any Pou4f2 mutation (1 available)
Pou4f2tm2.1Nat mutation (1 available); any Pou4f2 mutation (1 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• retinal ganglion cells (RGC) have larger surface area and thick arbors (J:147350)
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data (J:147350)
• a small percentage of RGC lack axons (J:147350)
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL) (J:147350)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls (J:147350)
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells (J:147350)
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract (J:147350)
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing (J:147350)
• retinal ganglion cells (RGC) have larger surface area and thick arbors (J:147350)
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data (J:147350)
• a small percentage of RGC lack axons (J:147350)
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL) (J:147350)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls (J:147350)
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells (J:147350)
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract (J:147350)
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing (J:147350)
• 70% of retinal ganglion cells are not present (J:147350)
• 70% of retinal ganglion cells are not present (J:147350)

nervous system
• large decrements in RGC projections occur to the nucleus adjacent to the optic tract compared to controls (J:147350)
• the accessory optic tract is missing (J:147350)
• numerous neurites emerge at P4 from the optic tract and penetrate nearby nontarget areas (J:147350)
• large decrements in RGC projections occur to the nucleus adjacent to the optic tract compared to controls (J:147350)
• the accessory optic tract is missing (J:147350)
• numerous neurites emerge at P4 from the optic tract and penetrate nearby nontarget areas (J:147350)
• large decrements in RGC projections occur to this part of the brain compared to controls (J:147350)
• large decrements in RGC projections occur to this part of the brain compared to controls (J:147350)
• large decrements in RGC projections occur to this part of the brain compared to controls (J:147350)
• large decrements in RGC projections occur to this part of the brain compared to controls (J:147350)
• retinal ganglion cells (RGC) have larger surface area and thick arbors (J:147350)
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data (J:147350)
• a small percentage of RGC lack axons (J:147350)
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL) (J:147350)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls (J:147350)
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells (J:147350)
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract (J:147350)
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing (J:147350)
• retinal ganglion cells (RGC) have larger surface area and thick arbors (J:147350)
• some RGC axons follow aberrant trajectories, bifurcate within the retina or give rise to dendrite-like branches that ramify within the inner plexiform data (J:147350)
• a small percentage of RGC lack axons (J:147350)
• RGC cell body is more likely to reside in the inner nuclear layer (INL) than in the ganglion cell layer (GCL) (J:147350)
• the ratio of INL:GCL cell bodies is 178:105 compared with 9:147 for controls (J:147350)
• these misplaced RGC display morphological characteristics of glycinergic amacrine cells (J:147350)
• projections from the RGC are deficient to the olivary pretectal nucleus, the pretectal area and adjacent nucleus of the optic tract (J:147350)
• projections to the lateral and medial terminal nuclei are eliminated and the accessory optic tract is missing (J:147350)
• 70% of retinal ganglion cells are not present (J:147350)
• 70% of retinal ganglion cells are not present (J:147350)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory