Pou4f1^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Pou4f1^tm1Nat
• Name: POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:2387665
• Synonyms: Brn-3a-
• Gene: Pou4f1 Location: Chr14:104699112-104705435 bp, - strand Genetic Position: Chr14, 54.21 cM, cytoband E1-E3
• Alliance: Pou4f1^tm1Nat page

Behavioral differences between +/+ wild-type and Pou4f1^tm1Nat/Pou4f1^tm1Nat mice at birth

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35877
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette inserted by homologous recombination. Immunohistochemical analysis of retinal tissue verified that protein was not produced by the targeted locus. (J:35877)

Expression

In Mice Carrying this Mutation:	126 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f1 Mutation: 13 strains or lines available

References

• Original: J:35877 Xiang M, et al., Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11950-5
• All: 34 reference(s)