Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1Nat mutation
(0 available);
any
Pou4f1 mutation
(13 available)
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nervous system
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• by E11.5 abnormal axon bundles emerge from trigeminal ganglia
• premature branching of nerves, particularly the ophthalmic and maxillary branches
• sensory neurons from the maxillary division fail to encircle whisker follicles in a normal fashion
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1Nat mutation
(0 available);
any
Pou4f1 mutation
(13 available)
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Behavioral differences between +/+ wild-type and Pou4f1tm1Nat/Pou4f1tm1Nat mice at birth
mortality/aging
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• homozygotes die within the first 24 hours after birth
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behavior/neurological
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• as a result of a lack of coordinated limb and trunck movements
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nervous system
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• reduced cell number in the caudal region of the olivary nucleus
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• large neurons of the red nucleus are missing
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• 2 fold reduction in cell numbers in the medial habenula
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• 30% reduction of neurons in the spiral ganglion
• neurons are scattered and some are not well separated from the vestibular ganglion
• losses of sensory neurons in the cochlea as well as of afferent innervation
• misdirected fibers throughout the cochlea
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• 30-50% reduction of neurons at E18.5
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• volume of trigeminal ganglion about 1/2 normal just before birth
(J:35877)
• increased density of smaller cells
(J:35877)
• increased incidence of apoptotic cell death at E15.5
(J:54859)
• neuronal number begins to drop between E11.5 and E15.5
(J:54859)
• at birth neuron number about 30% normal
(J:54859)
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• volume is decreased and the size of neurons is decreased
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1Et mutation
(0 available);
any
Pou4f1 mutation
(13 available)
Pou4f1tm1Nat mutation
(0 available);
any
Pou4f1 mutation
(13 available)
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mortality/aging
vision/eye
N |
• no differences are seen in the optic chiasm or tracts at E16.5 or in retinofungal projections at E18.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1Nat mutation
(0 available);
any
Pou4f1 mutation
(13 available)
Pou4f1tm2.1Nat mutation
(1 available);
any
Pou4f1 mutation
(13 available)
Tg(Pax6-cre,GFP)2Pgr mutation
(1 available)
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nervous system
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• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated
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vision/eye
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• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice
• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes
• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated
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