Atrip^tm1.1Pof
Targeted Allele Detail

Summary

• Symbol: Atrip^tm1.1Pof
• Name: ATR interacting protein; targeted mutation 1.1, Pierre-Olivier Frappart
• MGI ID: MGI:6501143
• Synonyms: Atrip^Flox
• Gene: Atrip Location: Chr9:108888815-108903192 bp, - strand Genetic Position: Chr9, 59.63 cM, cytoband F2
• Alliance: Atrip^tm1.1Pof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299031
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 1-3 floxed. (J:299031)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atrip Mutation: 26 strains or lines available

References

• Original: J:299031 Matos-Rodrigues GE, et al., ATRIP protects progenitor cells against DNA damage in vivo. Cell Death Dis. 2020 Oct 28;11(10):923
• All: 2 reference(s)