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| Caption | Spatially localized Edn2 expression results in local inhibition of retinal vascular development in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pax6-cre,GFP)2Pgr/0 (Z/Edn2;Pax6alpha-Cre) mice. (A, Upper) Sections of mutant retinas stained with GS-lectin after Vegfa in situ hybridization. (A, Lower) mutant retinas immunostained for Hypoxyprobe. (A, Left) Vascular architecture appears close to normal in the central retina, where Pax6alpha-Cre is not expressed; there is a low level of Vegfa expression in the INL and a low level of Hypoxyprobe accumulation. (A, Right) Hypertrophic blood vessels on the vitreal face of the retina with attenuated intraretinal projections are seen in the peripheral retina, where Cre-mediated recombination has activated Edn2 expression from the Z/Edn2 locus. This region has high expression of Vegfa in Muller glia and high levels of Hypoxyprobe. (Scale bar: 200 um.) (B) Flat mount of control and mutant retinas stained for Hypoxyprobe and GS-lectin. (Scale bar: 500 um.) (C) The front of the IPL vasculature in an adult mutant retina immunostained for Tie2 and PECAM1. Arrowheads point to several ECs at the vascular front that are decorated with filopodia and express low levels of Tie2. The retinal center is to the left, and the periphery is to the right. (Scale bar: 100 um.) | ||||||
| Copyright | This image is from Rattner A, Proc Natl Acad Sci U S A 2013 Oct 1;110(40):E3830-E3839. Copyright 2013 National Academy of Sciences, U.S.A. J:201133 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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