Phenotypes associated with this allele

• Allele Symbol: Tcrd^tm1Mom
• Allele Name: targeted mutation 1, Peter Mombaerts
• Allele ID: MGI:1857257
• Summary: 22 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcrd^tm1Mom/Tcrd^tm1Mom	B6.129P2-Tcrd^tm1Mom	MGI:3620215
hm2	Tcrd^tm1Mom/Tcrd^tm1Mom	B6;129P2-Tcrd^tm1Mom/J	MGI:3767443
hm3	Tcrd^tm1Mom/Tcrd^tm1Mom	either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3761088
hm4	Tcrd^tm1Mom/Tcrd^tm1Mom	FVB.129P2-Tcrd^tm1Mom	MGI:3620213
hm5	Tcrd^tm1Mom/Tcrd^tm1Mom	NOD.129P2-Tcrd^tm1Mom	MGI:3620214
cn6	Gt(ROSA)26Sor^tm10(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^+ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ	MGI:5314090
cn7	Gt(ROSA)26Sor^tm10(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ	MGI:5314093
cn8	Gt(ROSA)26Sor^tm11(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^+ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5314091
cn9	Gt(ROSA)26Sor^tm11(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5314096
cn10	Atg16l1^tm1c(EUCOMM)Wtsi/Atg16l1^tm1c(EUCOMM)Wtsi Tcrd^tm1Mom/Tcrd^tm1Mom Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * SJL	MGI:7564089
cx11	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Igh-J^tm2(3H9-VDJ*)Mwg/Igh-J^+	B6.129P2-Tcrb^tm1Mom Igh-J^tm2(3H9-VDJ*)Mwg Tcrd^tm1Mom	MGI:3836921
cx12	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	B6.129P2-Tcrb^tm1Mom Tcrd^tm1Mom/J	MGI:3767441
cx13	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix	B6.129-Tcrb^tm1Mom Traf3ip2^tm1.1Lix Tcrd^tm1Mom	MGI:5440219
cx14	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	FVB.129P2-Tcrb^tm1Mom Tcrd^tm1Mom	MGI:3620216
cx15	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129 * BALB/c * C57BL/6	MGI:3769901
cx16	Tcrd^tm1Mom/Tcrd^tm1Mom Tcrg^tm2.1Dhr/Tcrg^tm2.1Dhr	involves: 129 * C57BL/6	MGI:3813519
cx17	Itk^tm1Ljb/Itk^tm1Ljb Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129 * C57BL/6 * C57BL/10	MGI:4354603
cx18	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129P2/OlaHsd	MGI:3818331
cx19	Rr149356^tm1Che/Rr149356^tm1Che Tcrd^tm1Mom/Tcrd^tm1Mom Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:3620761
cx20	Tcrd^tm1Mom/Tcrd^tm1Mom Tnf^tm2Gkl/Tnf^+	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:3629523
cx21	Pigr^tm1Ohw/Pigr^tm1Ohw Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	MGI:3818332
cx22	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129P2/OlaHsd * C57BL/6	MGI:3767322

Genotype
MGI:3620215

hm1

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: B6.129P2-Tcrd^tm1Mom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:75915 )

N • Background Sensitivity: no evidence of spontaneous dermatitis, allergic or irritant contact dermatitis

cellular

increased apoptosis ( J:94872 )

• apoptosis levels in the epidermis are 3 fold higher than in controls

integument

integument phenotype ( J:75915 )

N • Background Sensitivity: no skin abnormalities

Genotype
MGI:3767443

hm2

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: B6;129P2-Tcrd^tm1Mom/J

respiratory system

abnormal respiratory system physiology ( J:125656 )

• ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation

Genotype
MGI:3761088

hm3

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: either: (involves: 129P2/OlaHsd * BALB/cJ) or (involves: 129P2/OlaHsd * C57BL/6)

immune system

abnormal gamma-delta T cell differentiation ( J:3865 )

• rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur

absent gamma-delta T cells ( J:3865 )

• gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control

hematopoietic system

abnormal gamma-delta T cell differentiation ( J:3865 )

• rearrangement of Vgamma and Vdelta genes occurs in fetal and adult thymus, however, surface expression does not occur

absent gamma-delta T cells ( J:3865 )

• gamma-delta T cells are not detected by flow cytometry in lymphoid or epithelial organs of 4 week old mice or in fetal thymocytes (Day 16), however, levels of alpha-beta T cells and B cells are similar to control

Genotype
MGI:3620213

hm4

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: FVB.129P2-Tcrd^tm1Mom

immune system

increased susceptibility to type IV hypersensitivity reaction ( J:75915 )

• Background Sensitivity: aggravated allergic contact dermatitis in response to DNFAB and irritant contact dermatitis

dermatitis ( J:75915 )

• Background Sensitivity: no overt signs of spontaneous dermatitis on this background

homeostasis/metabolism

impaired skin barrier function ( J:106782 )

• transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions

integument

impaired skin barrier function ( J:106782 )

• transepidermal water loss as measured by skin surface impedance is increased under environmentally stressful conditions

dermatitis ( J:75915 )

• Background Sensitivity: no overt signs of spontaneous dermatitis on this background

abnormal skin condition ( J:75915 )

• Background Sensitivity: less extensive ear thickening

Genotype
MGI:3620214

hm5

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: NOD.129P2-Tcrd^tm1Mom

immune system

dermatitis ( J:75915 )

• Background Sensitivity: spontaneous cutaneous inflammation of the ears develops

• Background Sensitivity: inflammation involves erythema, edema, and purities

• Background Sensitivity: appears by 5-6 weeks and becomes more obvious with age

integument

dermatitis ( J:75915 )

• Background Sensitivity: spontaneous cutaneous inflammation of the ears develops

• Background Sensitivity: inflammation involves erythema, edema, and purities

• Background Sensitivity: appears by 5-6 weeks and becomes more obvious with age

abnormal skin condition ( J:75915 )

Genotype
MGI:5314090

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm10(Lmp1)Rsky}/Gt(ROSA)26Sor⁺; Tcrb^tm1Mom/Tcrb⁺; Tcrd^tm1Mom/Tcrd^tm1Mom; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged spleen ( J:181546 )

Genotype
MGI:5314093

cn7

• Allelic Composition: Gt(ROSA)26Sor^{tm10(Lmp1)Rsky}/Gt(ROSA)26Sor⁺; Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

liver/biliary system

enlarged liver ( J:181546 )

• occasionally

neoplasm

increased B cell derived lymphoma incidence ( J:181546 )

• most tumors resemble diffuse large B cell lymphomas (in 6 of 9 mice)

increased plasmacytoma incidence ( J:181546 )

• in 3 of 9 mice

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged liver ( J:181546 )

• occasionally

enlarged spleen ( J:181546 )

Genotype
MGI:5314091

cn8

• Allelic Composition: Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺; Tcrb^tm1Mom/Tcrb⁺; Tcrd^tm1Mom/Tcrd^tm1Mom; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged spleen ( J:181546 )

Genotype
MGI:5314096

cn9

• Allelic Composition: Gt(ROSA)26Sor^{tm11(Lmp1)Rsky}/Gt(ROSA)26Sor⁺; Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

mortality/aging

premature death ( J:181546 )

immune system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

liver/biliary system

enlarged liver ( J:181546 )

• occasionally

neoplasm

increased B cell derived lymphoma incidence ( J:181546 )

• most tumors resemble diffuse large B cell lymphomas (in 6 of 9 mice)

increased plasmacytoma incidence ( J:181546 )

• in 3 of 9 mice

hematopoietic system

enlarged spleen ( J:181546 )

increased B cell number ( J:181546 )

growth/size/body

enlarged liver ( J:181546 )

• occasionally

enlarged spleen ( J:181546 )

Genotype
MGI:7564089

cn10

• Allelic Composition: Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi}; Tcrd^tm1Mom/Tcrd^tm1Mom; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * SJL

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

digestive/alimentary system

increased small intestinal crypt cell apoptosis ( J:340266 )

abnormal Paneth cell morphology ( J:340266 )

• remaining Paneth cells display abnormal lysozyme staining patterns

decreased Paneth cell number ( J:340266 )

• spontaneous Paneth cell loss in the absence of infection with murine norovirus

• however, goblet cell numbers are similar to controls

decreased small intestinal villus height ( J:340266 )

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

homeostasis/metabolism

abnormal cytokine level ( J:340266 )

• increased local levels of cytokine production in the small intestine

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:340266 )

• increased susceptibility to mortality following treatment with 5% dextran sulfate sodium even in the absence of mouse norovirus infection

• injection with recombinant Api5 improved survival

abnormal cytokine level ( J:340266 )

• increased local levels of cytokine production in the small intestine

cellular

increased small intestinal crypt cell apoptosis ( J:340266 )

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:340266 )

• remaining Paneth cells display abnormal lysozyme staining patterns

decreased Paneth cell number ( J:340266 )

• spontaneous Paneth cell loss in the absence of infection with murine norovirus

• however, goblet cell numbers are similar to controls

Genotype
MGI:3836921

cx11

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom; Igh-J^{tm2(3H9-VDJ*)Mwg}/Igh-J⁺
• Genetic Background: B6.129P2-Tcrb^tm1Mom Igh-J^{tm2(3H9-VDJ*)Mwg} Tcrd^tm1Mom

immune system

increased marginal zone B cell number ( J:142389 )

• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls

spleen hypoplasia ( J:142389 )

• spleen has 1.9- to 2.9- fold fewer spleen cells than controls

increased anti-double stranded DNA antibody level ( J:142389 )

• anti-dsDNA antibodies of the IgG2a isotype are detected in the sera of mice from 1 to 3 months of age

• anti-dsDNA antibodies with IgM, IgG2b, IgG3 isotypes are also present with levels of IgG3 extremly high compared to controls

• at 3 months of age, levels are higher than those found in 56R mice that have peripheral T cells

hematopoietic system

increased marginal zone B cell number ( J:142389 )

• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls

spleen hypoplasia ( J:142389 )

• spleen has 1.9- to 2.9- fold fewer spleen cells than controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:142389

Genotype
MGI:3767441

cx12

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: B6.129P2-Tcrb^tm1Mom Tcrd^tm1Mom/J

immune system

abnormal transitional stage B cell morphology ( J:187766 )

• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice

decreased plasma cell number ( J:187766 )

• mutants exhibit a reduction in plasma cells (B220low IgD-CD138+)

increased B cell number ( J:187766 )

• in the spleen

increased immature B cell number ( J:187766 )

• 16-18 week old mutants exhibit increased numbers of immature B cells

increased transitional stage T2 B cell number ( J:187766 )

• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells

increased transitional stage T3 B cell number ( J:187766 )

• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells

increased mature B cell number ( J:187766 )

• mutants exhibit an elevation in mature B cells, including both marginal zone and follicular mature B-cell subsets

increased follicular B cell number ( J:187766 )

increased marginal zone B cell number ( J:187766 )

decreased T cell number ( J:187766 )

• in the spleen

decreased IgE level ( J:125656 )

• IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type

decreased IgG level ( J:125656 , J:187766 )

• in OVA-treated mutants, serum IgG is reduced below saline-treated control levels (J:125656)

decreased IgG1 level ( J:125656 )

• IgG1 is not detected in serum after OVA challenge

increased IgM level ( J:187766 )

• mutants exhibit elevated levels of IgM deposition within kidney glomeruli

decreased autoantibody level ( J:187766 )

• decrease in anti-chromatin IgG, anti-histone IgG, and anti-dsDNA IgG

respiratory system

abnormal respiratory system physiology ( J:125656 )

• ovalbumin-sensitized/challenged mice (OVA) are unable to generate an early phase reaction (EPR- initial phase of brochoconstriction) following OVA provocation

hematopoietic system

abnormal transitional stage B cell morphology ( J:187766 )

• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice

decreased plasma cell number ( J:187766 )

• mutants exhibit a reduction in plasma cells (B220low IgD-CD138+)

increased B cell number ( J:187766 )

• in the spleen

increased immature B cell number ( J:187766 )

• 16-18 week old mutants exhibit increased numbers of immature B cells

increased transitional stage T2 B cell number ( J:187766 )

• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells

increased transitional stage T3 B cell number ( J:187766 )

• mutants exhibit an elevation in T2 and to a lesser extent T3 B cells

increased mature B cell number ( J:187766 )

• mutants exhibit an elevation in mature B cells, including both marginal zone and follicular mature B-cell subsets

increased follicular B cell number ( J:187766 )

increased marginal zone B cell number ( J:187766 )

decreased T cell number ( J:187766 )

• in the spleen

decreased IgE level ( J:125656 )

• IgE is not detectable in serum of OVA-treated mutants, but high levels are produced in treated wild-type

decreased IgG level ( J:125656 , J:187766 )

• in OVA-treated mutants, serum IgG is reduced below saline-treated control levels (J:125656)

decreased IgG1 level ( J:125656 )

• IgG1 is not detected in serum after OVA challenge

increased IgM level ( J:187766 )

• mutants exhibit elevated levels of IgM deposition within kidney glomeruli

renal/urinary system

renal glomerular immunoglobulin deposits ( J:187766 )

• mutants exhibit elevated levels of IgM deposition within kidney glomeruli, however IgG deposition in the glomeruli is not seen

Genotype
MGI:5440219

cx13

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom; Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix
• Genetic Background: B6.129-Tcrb^tm1Mom Traf3ip2^tm1.1Lix Tcrd^tm1Mom

immune system

immune system phenotype ( J:187766 )

N • triple mutants exhibit reduced lupus-like phenotypes compared to Traf3ip2 single homozygotes, with normal spleen weight and cellularity, normal B cell numbers (B cell numbers however are decreased compared to Tcrb and Tcrd double homozygous mutants), normal cervical lymph node weight and cellularity, significantly less total IgG antibodies and anti-nuclear antigen specific IgG autoantibodies, and no IgG deposition in the kidney glomeruli

increased immature B cell number ( J:187766 )

• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells

abnormal transitional stage B cell morphology ( J:187766 )

• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice

increased marginal zone B cell number ( J:187766 )

• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels

decreased T cell number ( J:187766 )

• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes

decreased IgG level ( J:187766 )

• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes

• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants

increased IgM level ( J:187766 )

• mutants exhibit elevated levels of IgM deposition within kidney glomeruli

• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes

increased autoantibody level ( J:187766 )

increased anti-chromatin antibody level ( J:187766 )

• serum levels of anti-chromatin IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes

increased anti-double stranded DNA antibody level ( J:187766 )

• serum levels anti-dsDNA IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes

increased anti-histone antibody level ( J:187766 )

• serum levels of anti-histone IgM are elevated in triple mutants compared to Traf3ip2 single homozygotes

hematopoietic system

increased immature B cell number ( J:187766 )

• 16-18 week old mutants exhibit a trend toward an increase in numbers of immature B cells

abnormal transitional stage B cell morphology ( J:187766 )

• ratios of T2:T1 and T3:T1 B cells are increased compared to wild-type mice

increased marginal zone B cell number ( J:187766 )

• mutants exhibit increased levels of marginal zone B cells compared to wild-type mice, however levels are similar to that seen in Traf3ip2 single homozygotes or to Tcrb and Tcrd double homozygous mutants, indicating no further increase in levels

decreased T cell number ( J:187766 )

• decrease in the number of T cells in the spleen compared to wild-type mice and Traf3ip2 single homozygotes

decreased IgG level ( J:187766 )

• mutants develop significantly less total IgG antibodies (IgG, IgG1, IgG2c) and anti-nuclear antigen specific IgG autoantibodies than Traf3ip2 single homozygotes

• the IgG deposition within the kidney glomeruli that is seen in Traf3ip2 single homozygotes is not seen in triple mutants

increased IgM level ( J:187766 )

• mutants exhibit elevated levels of IgM deposition within kidney glomeruli

• serum levels of anti-chromatin IgM, anti-histone IgM, and anti-dsDNA Igm are elevated in triple mutants compared to Traf3ip2 single homozygotes

cardiovascular system

abnormal glomerular capillary morphology ( J:187766 )

• kidneys show occasional obstruction of the capillary lumina

renal/urinary system

abnormal glomerular capillary morphology ( J:187766 )

• kidneys show occasional obstruction of the capillary lumina

increased mesangial cell number ( J:187766 )

• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease

renal glomerular immunoglobulin deposits ( J:187766 )

• mutants exhibit elevated levels of IgM deposition within kidney glomeruli

cellular

increased mesangial cell number ( J:187766 )

• kidneys show moderate hypercellularity of the glomerular mesangium and occasional obstruction of the capillary lumina, however no signs of mononuclear cell infiltrates or signs of tubulointerstitial disease

Genotype
MGI:3620216

cx14

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: FVB.129P2-Tcrb^tm1Mom Tcrd^tm1Mom

immune system

immune system phenotype ( J:75915 )

N • no sign of spontaneous or contact dermatitis

Genotype
MGI:3769901

cx15

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: involves: 129 * BALB/c * C57BL/6

immune system

colitis ( J:15221 )

• very mild colitis occurs in some aged mice

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

absent CD4-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

absent CD8-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

digestive/alimentary system

colitis ( J:15221 )

• very mild colitis occurs in some aged mice

hematopoietic system

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

absent CD4-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

absent CD8-positive, alpha-beta T cells ( J:3206 )

• cells are absent in the thymus

endocrine/exocrine glands

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

Genotype
MGI:3813519

cx16

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom; Tcrg^tm2.1Dhr/Tcrg^tm2.1Dhr
• Genetic Background: involves: 129 * C57BL/6

immune system

abnormal T cell receptor gamma chain V-J recombination ( J:75624 )

• Vgamma2 rearrangement is reduced by 2-fold in the adult thymus compared to Tcrd^tm1Mom homozygotes

hematopoietic system

abnormal T cell receptor gamma chain V-J recombination ( J:75624 )

• Vgamma2 rearrangement is reduced by 2-fold in the adult thymus compared to Tcrd^tm1Mom homozygotes

Genotype
MGI:4354603

cx17

• Allelic Composition: Itk^tm1Ljb/Itk^tm1Ljb; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10

immune system

immune system phenotype ( J:148531 )

N • the hyper-IgE and increased numbers of germinal center B cells are at normal levels in these mice

Genotype
MGI:3818331

cx18

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd

immune system

immune system phenotype ( J:97824 )

N • the numbers of intraepithelial lymphocytes in the small intestine is normal

increased T cell number ( J:97824 )

• the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrd^tm1Mom homozygotes

decreased lymphocyte cell number ( J:97824 )

• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice

decreased IgA level ( J:97824 )

• in the serum compared to wild-type mice

hematopoietic system

increased T cell number ( J:97824 )

• the numbers of Thy1+ and CD8alpha,beta+ TCR-alpha,beta intraepithelial lymphocytes is increased compared to in Tcrd^tm1Mom homozygotes

decreased lymphocyte cell number ( J:97824 )

• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice

decreased IgA level ( J:97824 )

• in the serum compared to wild-type mice

Genotype
MGI:3620761

cx19

• Allelic Composition: Rr149356^tm1Che/Rr149356^tm1Che; Tcrd^tm1Mom/Tcrd^tm1Mom; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

immune system

abnormal double-negative T cell morphology ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

• mean survival around 14 weeks

hematopoietic system

abnormal double-negative T cell morphology ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:106246 )

• most thymocytes are double negative at 4 weeks of age but quickly progress to double positive and then CD8 single positive lymphomas

• mean survival around 14 weeks

Genotype
MGI:3629523

cx20

• Allelic Composition: Tcrd^tm1Mom/Tcrd^tm1Mom; Tnf^tm2Gkl/Tnf⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

immune system

small intestinal inflammation ( J:108572 )

• development and severity of inflammatory bowel disease are similar to Tnf^tm2Gkl/+, wild-type B2m controls

digestive/alimentary system

small intestinal inflammation ( J:108572 )

• development and severity of inflammatory bowel disease are similar to Tnf^tm2Gkl/+, wild-type B2m controls

Genotype
MGI:3818332

cx21

• Allelic Composition: Pigr^tm1Ohw/Pigr^tm1Ohw; Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

immune system

immune system phenotype ( J:97824 )

N • unlike in Pigr^tm1Ohw homozygotes, the numbers of intraepithelial lymphocytes in the small intestine is normal

decreased lymphocyte cell number ( J:97824 )

• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice

increased IgA level ( J:97824 )

• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigr^tm1Ohw homozygotes

hematopoietic system

decreased lymphocyte cell number ( J:97824 )

• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice

increased IgA level ( J:97824 )

• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigr^tm1Ohw homozygotes

Genotype
MGI:3767322

cx22

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tcrd^tm1Mom/Tcrd^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

respiratory system

abnormal respiratory system morphology ( J:119344 )

• after 4 weeks, mice show absence of vascular remodeling of the airways in response to Mycoplasma pulmonis infection wherease wild-type show complex growth and reorganization ot the vascular beds

abnormal respiratory system physiology ( J:119344 )

• abnormalities in epithelial cell differentiation and mucus secretion are intermediate between wild-type and Igh-6 deficient mice after M. pulmonis infection

immune system

immune system phenotype ( J:126867 )

N • proliferation of intestinal epithelial cells (IECs) and MHC class II expression on IECs is comparable to controls

decreased IgG level ( J:119344 )

• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected

abnormal response to infection ( J:119344 )

• bacteria are present in liver and kidney of mice after 4 weeks of M. pulmonis infection, but bacteria are absent from wild-type mouse tissue

• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection

hematopoietic system

decreased IgG level ( J:119344 )

• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected