Rr149356^tm1Che
Targeted Allele Detail

Summary

• Symbol: Rr149356^tm1Che
• Name: regulatory region 149356; targeted mutation 1, Jianzhu Chen
• MGI ID: MGI:3620665
• Synonyms: Ebeta^R
• Gene: Rr149356 Location: Chr6:41526801-41532817 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr149356^tm1Che page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107306
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A concatamer of 8 copies of the Lgals4 binding sequence replaced 560 bp of the locus to inactivate the enhancer and to allow opportunitites to target heterologous proteins to the locus. A floxed neo cassette included in the vector was deleted by cre-mediated excision. (J:107306)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr149356 Mutation: 0 strains or lines available

References

• Original: J:107306 Ryu CJ, et al., The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13465-70
• All: 3 reference(s)