Pigr^tm1Ohw
Targeted Allele Detail

Summary

• Symbol: Pigr^tm1Ohw
• Name: polymeric immunoglobulin receptor; targeted mutation 1, Makoto Ohwaki
• MGI ID: MGI:2445730
• Synonyms: pIgR^-
• Gene: Pigr Location: Chr1:130754421-130779986 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband E3
• Alliance: Pigr^tm1Ohw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58454
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. While low levels of normal size transcript were identified in homozygous mutant mice by Northern blot analysis, no protein was detected by Western blot analysis. (J:58454)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pigr Mutation: 59 strains or lines available

References

• Original: J:58454 Shimada S, et al., Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA. J Immunol. 1999 Nov 15;163(10):5367-73
• All: 12 reference(s)