Pigr MGI Mouse Gene Detail - MGI:103080 - polymeric immunoglobulin receptor

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Pigr Gene Detail

Symbol

Pigr
Name

polymeric immunoglobulin receptor

Feature Type

protein coding gene
IDs

MGI:103080
NCBI Gene: 18703
Alliance

gene page
Transcription Start Sites

29 TSS

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Sequence Map

Chr1:130754421-130779986 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM, cytoband E3
Mapping Data

5 experiments

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SNPs within 2kb

276 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_103080	protein coding gene	Chr1:130754421-130779986 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016442	protein coding gene	Chr1:134228230-134256793 (+)
A/J	MGP_AJ_G0016425	protein coding gene	Chr1:129260977-129286505 (+)
AKR/J	MGP_AKRJ_G0016390	protein coding gene	Chr1:133063883-133091429 (+)
BALB/cJ	MGP_BALBcJ_G0016385	protein coding gene	Chr1:129593289-129618808 (+)
C3H/HeJ	MGP_C3HHeJ_G0016211	protein coding gene	Chr1:133207731-133233284 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016846	protein coding gene	Chr1:139227017-139252527 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014560	protein coding gene	Chr1:122404176-122430542 (+)
CAST/EiJ	MGP_CASTEiJ_G0015791	protein coding gene	Chr1:132198061-132223634 (+)
CBA/J	MGP_CBAJ_G0016183	protein coding gene	Chr1:144025905-144051414 (+)
DBA/2J	MGP_DBA2J_G0016290	protein coding gene	Chr1:128223146-128248681 (+)
FVB/NJ	MGP_FVBNJ_G0016289	protein coding gene	Chr1:126867641-126893175 (+)
LP/J	MGP_LPJ_G0016361	protein coding gene	Chr1:135541107-135566627 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016314	protein coding gene	Chr1:149790796-149816312 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016882	protein coding gene	Chr1:132827829-132853346 (+)
PWK/PhJ	MGP_PWKPhJ_G0015577	protein coding gene	Chr1:127197131-127222757 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015364	protein coding gene	Chr1:131757900-131785773 (+)
WSB/EiJ	MGP_WSBEiJ_G0015853	protein coding gene	Chr1:132802214-132827748 (+)

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Human Ortholog

PIGR, polymeric immunoglobulin receptor

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIGR, polymeric immunoglobulin receptor
Links

HGNC:8968

NCBI Gene ID: 5284

neXtProt AC: NX_P01833

UniProt: P01833
Chr Location

1q32.1; chr1:206928522-206946466 (-) GRCh38

MGI Vertebrate Homology

Pigr stringent orthology
1 human;1 mouse;1 rat;6 zebrafish
HCOP

vertebrate homology predictions: PIGR
Gene Tree

Pigr

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Phenotype Summary

19 phenotypes from 3 alleles in 5 genetic backgrounds
3 phenotypes from multigenic genotypes
46 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Pigr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show impaired transepithelial transport of dimeric IgA, increased serum IgA levels and mucosal leakiness. Studies of one null allele show increased susceptibility to mycobacterial infections while another allele causes impaired clearanceof the protozoan parasite Giardia.

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All GO Annotations

26
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

4
cDNA Data

169
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS15260.1

Ensembl

ENSMUSG00000026417 (Evidence)
NCBI Gene

18703

Representative Sequences				Length	Strain/Species	Flank
	genomic	18703	NCBI Gene Model \| MGI Sequence Detail	25566	C57BL/6J	± kb
	transcript	NM_011082	RefSeq \| MGI Sequence Detail	3849	ZRU/MplStud
	polypeptide	O70570	UniProt \| EBI \| MGI Sequence Detail	771	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012705 polymeric immunoglobulin receptor

(term hierarchy)
PDB

4NOB, 4NOF, 7JG2
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR013106 Immunoglobulin V-set domain

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All nucleic 190

Genomic 18

cDNA 170

Primer pair 2

Microarray probesets 4

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MGD-MRK-23944

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Summaries

All 87

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 46
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:344567 Lin H, et al., Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction. Cell Death Dis. 2023 Jan 28;14(1):68

TSS for Pigr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8572	Chr1:130754396-130754402 (+)	-22 bp
Tssr8573	Chr1:130754413-130754492 (+)	32 bp
Tssr8574	Chr1:130754499-130754506 (+)	82 bp
Tssr8575	Chr1:130762132-130762153 (+)	7,722 bp
Tssr8576	Chr1:130769283-130769296 (+)	14,869 bp
Tssr8577	Chr1:130769429-130769441 (+)	15,014 bp
Tssr8578	Chr1:130772428-130772438 (+)	18,012 bp
Tssr8579	Chr1:130774106-130774138 (+)	19,701 bp
Tssr8580	Chr1:130775210-130775222 (+)	20,795 bp
Tssr8581	Chr1:130776171-130776183 (+)	21,756 bp
Tssr8582	Chr1:130776783-130776816 (+)	22,379 bp
Tssr8583	Chr1:130777309-130777320 (+)	22,894 bp
Tssr8584	Chr1:130778437-130778446 (+)	24,021 bp
Tssr8585	Chr1:130778470-130778479 (+)	24,054 bp
Tssr8586	Chr1:130779144-130779157 (+)	24,730 bp
Tssr8587	Chr1:130779170-130779181 (+)	24,755 bp
Tssr201	Chr1:130779184-130779191 (+)	24,767 bp
Tssr8588	Chr1:130779196-130779202 (+)	24,778 bp
Tssr8589	Chr1:130779270-130779281 (+)	24,855 bp
Tssr8590	Chr1:130779286-130779293 (+)	24,869 bp
Tssr8591	Chr1:130779321-130779337 (+)	24,908 bp
Tssr8592	Chr1:130779341-130779361 (+)	24,930 bp
Tssr8593	Chr1:130779362-130779394 (+)	24,957 bp
Tssr8594	Chr1:130779399-130779419 (+)	24,988 bp
Tssr8595	Chr1:130779427-130779442 (+)	25,014 bp
Tssr8596	Chr1:130779453-130779471 (+)	25,041 bp
Tssr8597	Chr1:130779472-130779500 (+)	25,065 bp
Tssr8598	Chr1:130779866-130779875 (+)	25,450 bp
Tssr8599	Chr1:130779911-130779915 (+)	25,492 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23