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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pigrtm1Ohw
targeted mutation 1, Makoto Ohwaki
MGI:2445730
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pigrtm1Ohw/Pigrtm1Ohw B6.129X1-Pigrtm1Ohw MGI:3818330
hm2
 		Pigrtm1Ohw/Pigrtm1Ohw involves: 129X1/SvJ * C57BL/6J MGI:3818311
cx3
 		Pigrtm1Ohw/Pigrtm1Ohw
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J MGI:3818332


Genotype
MGI:3818330
hm1
Allelic
Composition		 Pigrtm1Ohw/Pigrtm1Ohw
Genetic
Background		 B6.129X1-Pigrtm1Ohw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Ohw mutation (0 available); any Pigr mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal intraepithelial T cell number ( J:97824 )
• in the small intestine, the number of TCR-alpha,beta+ intraepithelial lymphocytes that are Thy1+ CD8alpha,beta+ is increased while the number of CD8alphalpha+ intraepithelial lymphocytes is decreased compared to in wild-type mice
• however, the numbers of TCR-alpha,beta cells are normal in the large intestine and in mice housed in germ-free environments
• the small intestine exhibit a slight increase in the numbers of Thy1+ TCR-gamma,delta+ intraepithelial lymphocytes and slight decrease in CD8alpha,alpha+ TCR-gamma,delta intraepithelial lymphocytes compared to in wild-type mice
• the numbers of Thy1.2+ and CD8alpha,beta lymphocytes in the small intestine are preferentially increased compared to in Tcrdtm1Mom homozygotes
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:97824 )
• the numbers of CD8alpha,beta lymphocytes in the small intestine are preferentially increased compared to in Tcrdtm1Mom homozygotes
• in the small intestine, the number of Thy1+ CD8alphabeta+ intraepithelial lymphocytes is increased while the number of CD8alphalpha+ intraepithelial lymphocytes is decreased compared to in wild-type mice
• however, the numbers of TCR-alpha,beta cells are normal in the large intestine and in mice housed in germ-free environments
abnormal lymphocyte physiology ( J:97824 )
• in adoptive transfer experiments, small intestine intraepithelial lymphocytes exhibit increased migration into intestinal epithelial compared to wild-type intestinal lymphocytes
• however, the cytotoxic function and proliferation rates of small intestine intraepithelial lymphocytes are normal
decreased IgA level ( J:108538 )
• IgA levels in the saliva are lower than in wild-type mice and following exposure to PstS-1 are decreased compared to in similarly treated wild-type mice
• however, IgA levels in bronchoalveolar lavage fluid following exposure to PstS-1 are normal
increased IgA level ( J:97824 , J:108538 )
• in the serum compared to in wild-type mice (J:97824)
• serum IgA levels are increased compared to in wild-type mice (J:108538)
decreased interferon-gamma secretion ( J:108538 )
• following exposure to Mycobacterium bovis bacillus Calmette-Guerin (BCG), mice exhibit decreased lung production of IFN-gamma and TNF-alpha compared to similarly treated wild-type mice
decreased tumor necrosis factor secretion ( J:108538 )
• following exposure to Mycobacterium bovis bacillus Calmette-Guerin (BCG), mice exhibit decreased lung production of IFN-gamma and TNF-alpha compared to similarly treated wild-type mice
increased susceptibility to bacterial infection ( J:108538 )
• following exposure to Mycobacterium bovis bacillus Calmette-Guerin (BCG), mice exhibit increased bacterial lung load and decreased lung production of IFN-gamma and TNF-alpha compared to wild-type mice
• 3 weeks following infection with M. tuberculosis, mice exhibit increased bacterial load with reduced macrophage and lymphocyte infiltrates and more necrosis and karyorrhexis among neutrophils compared to in similarly treated wild-type mice
• 8 weeks following infection with M. tuberculosis, mice exhibit a greater increase in granulomatous infiltration compared to similarly treated wild-type mice
• however, by 8 weeks following infection with M. tuberculosis mice exhibit a normal resistance

hematopoietic system
abnormal intraepithelial T cell number ( J:97824 )
• in the small intestine, the number of TCR-alpha,beta+ intraepithelial lymphocytes that are Thy1+ CD8alpha,beta+ is increased while the number of CD8alphalpha+ intraepithelial lymphocytes is decreased compared to in wild-type mice
• however, the numbers of TCR-alpha,beta cells are normal in the large intestine and in mice housed in germ-free environments
• the small intestine exhibit a slight increase in the numbers of Thy1+ TCR-gamma,delta+ intraepithelial lymphocytes and slight decrease in CD8alpha,alpha+ TCR-gamma,delta intraepithelial lymphocytes compared to in wild-type mice
• the numbers of Thy1.2+ and CD8alpha,beta lymphocytes in the small intestine are preferentially increased compared to in Tcrdtm1Mom homozygotes
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:97824 )
• the numbers of CD8alpha,beta lymphocytes in the small intestine are preferentially increased compared to in Tcrdtm1Mom homozygotes
• in the small intestine, the number of Thy1+ CD8alphabeta+ intraepithelial lymphocytes is increased while the number of CD8alphalpha+ intraepithelial lymphocytes is decreased compared to in wild-type mice
• however, the numbers of TCR-alpha,beta cells are normal in the large intestine and in mice housed in germ-free environments
abnormal lymphocyte physiology ( J:97824 )
• in adoptive transfer experiments, small intestine intraepithelial lymphocytes exhibit increased migration into intestinal epithelial compared to wild-type intestinal lymphocytes
• however, the cytotoxic function and proliferation rates of small intestine intraepithelial lymphocytes are normal
decreased IgA level ( J:108538 )
• IgA levels in the saliva are lower than in wild-type mice and following exposure to PstS-1 are decreased compared to in similarly treated wild-type mice
• however, IgA levels in bronchoalveolar lavage fluid following exposure to PstS-1 are normal
increased IgA level ( J:97824 , J:108538 )
• in the serum compared to in wild-type mice (J:97824)
• serum IgA levels are increased compared to in wild-type mice (J:108538)




Genotype
MGI:3818311
hm2
Allelic
Composition		 Pigrtm1Ohw/Pigrtm1Ohw
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Ohw mutation (0 available); any Pigr mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgA level ( J:58454 )
• IgA levels in the bile, feces, and intestinal secretions is lower than in wild-type mice
increased IgA level ( J:58454 )
• IgA levels in the serum are increased compared to in wild-type mice
• dimeric IgA accumulates in the blood to a greater extent than in wild-type mice
increased IgE level ( J:58454 )
• slightly at 19 weeks of age
increased IgG level ( J:58454 )
• slightly at 19 weeks of age

hematopoietic system
decreased IgA level ( J:58454 )
• IgA levels in the bile, feces, and intestinal secretions is lower than in wild-type mice
increased IgA level ( J:58454 )
• IgA levels in the serum are increased compared to in wild-type mice
• dimeric IgA accumulates in the blood to a greater extent than in wild-type mice
increased IgE level ( J:58454 )
• slightly at 19 weeks of age
increased IgG level ( J:58454 )
• slightly at 19 weeks of age




Genotype
MGI:3818332
cx3
Allelic
Composition		 Pigrtm1Ohw/Pigrtm1Ohw
Tcrbtm1Mom/Tcrbtm1Mom
Tcrdtm1Mom/Tcrdtm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Ohw mutation (0 available); any Pigr mutation (59 available)
Tcrbtm1Mom mutation (12 available); any Tcrb mutation (95 available)
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:97824 )
N
• unlike in Pigrtm1Ohw homozygotes, the numbers of intraepithelial lymphocytes in the small intestine is normal
decreased lymphocyte cell number ( J:97824 )
• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
increased IgA level ( J:97824 )
• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigrtm1Ohw homozygotes

hematopoietic system
decreased lymphocyte cell number ( J:97824 )
• the pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type micethe pool size of Thy-1+B220- and CD8alpha,beta+ cells in the small intestine intraepithelial lymphocyte population is smaller than in wild-type mice
increased IgA level ( J:97824 )
• serum IgA levels are increased compared to in wild-type mice but not as much as in Pigrtm1Ohw homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory