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Wt1 Gene Detail
Summary
  • Symbol
    Wt1
  • Name
    WT1 transcription factor
  • Synonyms
    D630046I19Rik, Wilms tumor 1 homolog, Wt-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98968
    NCBI Gene: 22431
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:104956874-105003959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 55.06 cM, cytoband E
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1361 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98968
 protein coding gene Chr2:104956874-105003961 (+)
129S1/SvImJ ENSMUSG00200007318
 protein coding gene Chr2:101785813-101832911 (+)
A/J ENSMUSG00195028285
 protein coding gene Chr2:101936395-101983765 (+)
AKR/J ENSMUSG00220004859
 protein coding gene Chr2:101687407-101734774 (+)
BALB/cJ ENSMUSG00180029494
 protein coding gene Chr2:101737406-101784791 (+)
C3H/HeJ ENSMUSG00175027650
 protein coding gene Chr2:102028248-102075634 (+)
C57BL/6NJ ENSMUSG00215014572
 protein coding gene Chr2:101842064-101889188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024034
 protein coding gene Chr2:98593727-98641533 (+)
CAST/EiJ ENSTCUG00005001388
 protein coding gene Chr2:101109096-101156721 (+)
CBA/J ENSMUSG00210036786
 protein coding gene Chr2:102015128-102062488 (+)
DBA/2J ENSMUSG00185037688
 protein coding gene Chr2:101734103-101781466 (+)
FVB/NJ ENSMUSG00205010929
 protein coding gene Chr2:101066503-101113841 (+)
JF1/MsJ ENSUMUG00000002950
 protein coding gene Chr2:101437744-101485157 (+)
LP/J ENSMUSG00230004818
 protein coding gene Chr2:103483388-103530742 (+)
NOD/ShiLtJ ENSMUSG00190014582
 protein coding gene Chr2:101867106-101914201 (+)
NZO/HlLtJ ENSMUSG00225008244
 protein coding gene Chr2:111390579-111437682 (+)
PWK/PhJ ENSLUMG00010023578
 protein coding gene Chr2:101442914-101490322 (+)
SPRET/EiJ ENSMSPG00010031562
 protein coding gene Chr2:103482346-103529839 (+)
WSB/EiJ ENSIUOG00005001413
 protein coding gene Chr2:101536400-101583565 (+)



Homology
more
  • Human Ortholog
    WT1, WT1 transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WT1, WT1 transcription factor
  • Synonyms
    AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33
  • Links
    NCBI Gene ID: 7490
    UniProt: P19544

  • Chr Location
    11p13; chr11:32387775-32435564 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Wt1 mouse models; 7 with human WT1 associations

Human Disease Mouse Models
      
IDs
 View 6 models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 15 alleles in 22 genetic backgrounds
    24 phenotypes from multigenic genotypes
    276 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice fail to develop normal kidneys or gonads, and on some genetic backgrounds, a spleen. Heart, mesothelium and lung anomalies and variable lethality are observed. Females heterozygous for a point mutation are subfertile with small ovaries and impaired ovarian folliculogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    141
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2530
  • Tissues
    800
  • cDNA Data
    33
  • Literature Summary
    574
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22431 NCBI Gene Model | MGI Sequence Detail 47086 C57BL/6J ±  kb
    transcript NM_144783 RefSeq | MGI Sequence Detail 3092 ZRU/MplStud  
    polypeptide P22561 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 12
      cDNA 35
      Primer pair 28
      Other 23
      Antibodies 50

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15464, MGD-MRK-15465, MGI:2441985
    References
    more
    • Summaries
      All 863
      Developmental Gene Expression 574
      Diseases 8
      Gene Ontology 40
      Phenotypes 276
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:391805 Ettou S, et al., FOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury. JCI Insight. 2026 Jun 8;11(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory