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Apoe Gene Detail
Summary
  • Symbol
    Apoe
  • Name
    apolipoprotein E
  • Feature Type
    protein coding gene
  • IDs
    MGI:88057
    NCBI Gene: 11816
  • Alliance
    genome feature page
  • Transcription Start Sites
    48 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19430034-19433113 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88057
 protein coding gene Chr7:19430034-19434326 (-)
129S1/SvImJ ENSMUSG00200038117
 protein coding gene Chr7:12627342-12630422 (-)
A/J ENSMUSG00195050152
 protein coding gene Chr7:13067384-13070465 (-)
AKR/J ENSMUSG00220025733
 protein coding gene Chr7:11399473-11402538 (-)
BALB/cJ ENSMUSG00180053063
 protein coding gene Chr7:12923711-12926790 (-)
C3H/HeJ ENSMUSG00175040300
 protein coding gene Chr7:13509881-13512961 (-)
C57BL/6NJ ENSMUSG00215054716
 protein coding gene Chr7:10777218-10780297 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029305
 protein coding gene Chr7:18995199-18998213 (-)
CAST/EiJ ENSTCUG00005049669
 protein coding gene Chr7:13532373-13535435 (-)
CBA/J ENSMUSG00210051197
 protein coding gene Chr7:12736422-12739504 (-)
DBA/2J ENSMUSG00185050723
 protein coding gene Chr7:16180058-16183123 (-)
FVB/NJ ENSMUSG00205049941
 protein coding gene Chr7:13118754-13121819 (-)
JF1/MsJ ENSUMUG00000023366
 protein coding gene Chr7:19493830-19496910 (-)
LP/J ENSMUSG00230052372
 protein coding gene Chr7:20469046-20472126 (-)
NOD/ShiLtJ ENSMUSG00190037286
 protein coding gene Chr7:9392734-9395814 (-)
NZO/HlLtJ ENSMUSG00225052115
 protein coding gene Chr7:17762467-17765532 (-)
PWK/PhJ ENSLUMG00010043081
 protein coding gene Chr7:2350509-2353587 (-)
SPRET/EiJ ENSMSPG00010042788
 protein coding gene Chr7:12469632-12474805 (-)
WSB/EiJ ENSIUOG00005052689
 protein coding gene Chr7:19141762-19144827 (+)



Homology
more
  • Human Ortholog
    APOE, apolipoprotein E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOE, apolipoprotein E
  • Synonyms
    AD2, APO-E, ApoE4, LDLCQ5, LPG
  • Links
    NCBI Gene ID: 348
    UniProt: P02649

  • Chr Location
    19q13.32; chr19:44903787-44909396 (+)  GRCh38
Human Diseases
more
  • Diseases
    41 with human APOE associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    13 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    175 phenotypes from 12 alleles in 27 genetic backgrounds
    316 phenotypes from multigenic genotypes
    19 images
    3212 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations at this locus cause diet-induced hypercholesterolemia and atherosclerosis. Homozygous null mutants also develop foam-cell rich deposits in proximal aorta, impaired blood-nerve and blood-brain barriers, and many xanthomatous lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    351
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    193
  • cDNA Data
    1790
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002985 Ensembl Gene Model | MGI Sequence Detail 3080 C57BL/6J ±  kb
    transcript ENSMUST00000003066 Ensembl | MGI Sequence Detail 1128 Not Applicable  
    polypeptide ENSMUSP00000003066 Ensembl | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1806
      Genomic 2
      cDNA 1790
      Primer pair 6
      Other 8
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1376, MGI:2141887
    References
    more
    • Summaries
      All 3809
      Developmental Gene Expression 52
      Diseases 13
      Gene Ontology 47
      Phenotypes 3212
    • Earliest
      J:5183 Forsthoefel PF, et al., Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970 Mar-Apr;61(2):64-6
    • Latest
      J:391305 Ou J, et al., Copper-Doped Prussian Blue Nanozymes With Hyaluronic Acid-Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy. Adv Sci (Weinh). 2026 Aug 5;:e76976
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory