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Hrh4 Gene Detail
Summary
  • Symbol
    Hrh4
  • Name
    histamine receptor H4
  • Synonyms
    H4R
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429635
    NCBI Gene: 225192
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:13140047-13155939 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 6.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    613 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429635
 protein coding gene Chr18:13140039-13156758 (+)
129S1/SvImJ ENSMUSG00200019336
 protein coding gene Chr18:10079710-10095615 (+)
A/J ENSMUSG00195002270
 protein coding gene Chr18:10269130-10285028 (+)
AKR/J ENSMUSG00220011671
 protein coding gene Chr18:10263627-10279526 (+)
BALB/cJ ENSMUSG00180003843
 protein coding gene Chr18:10718182-10734074 (+)
C3H/HeJ ENSMUSG00175004400
 protein coding gene Chr18:10257479-10273366 (+)
C57BL/6NJ ENSMUSG00215017327
 protein coding gene Chr18:9979586-9995481 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022011
 protein coding gene Chr18:9588717-9604988 (+)
CAST/EiJ ENSTCUG00005014456
 protein coding gene Chr18:10054878-10070911 (+)
CBA/J ENSMUSG00210020125
 protein coding gene Chr18:10266299-10282192 (+)
DBA/2J ENSMUSG00185007805
 protein coding gene Chr18:10274527-10290407 (+)
FVB/NJ ENSMUSG00205015510
 protein coding gene Chr18:10038832-10054722 (+)
JF1/MsJ ENSUMUG00000021688
 protein coding gene Chr18:10320090-10335998 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190016651
 protein coding gene Chr18:10038989-10054882 (+)
NZO/HlLtJ ENSMUSG00225027953
 protein coding gene Chr18:12256320-12272200 (+)
PWK/PhJ ENSLUMG00010015306
 protein coding gene Chr18:10531204-10547127 (+)
SPRET/EiJ ENSMSPG00010004670
 protein coding gene Chr18:10221375-10237456 (+)
WSB/EiJ ENSIUOG00005019326
 protein coding gene Chr18:10157419-10173324 (+)



Homology
more
  • Human Ortholog
    HRH4, histamine receptor H4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HRH4, histamine receptor H4
  • Synonyms
    AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
  • Links
    NCBI Gene ID: 59340
    UniProt: Q9H3N8

  • Chr Location
    18q11.2; chr18:24460637-24479974 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased allergic response to airway inflammation and decreased Th2 responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037346 Ensembl Gene Model | MGI Sequence Detail 15893 C57BL/6J ±  kb
    transcript ENSMUST00000041676 Ensembl | MGI Sequence Detail 1537 Not Applicable  
    polypeptide ENSMUSP00000041061 Ensembl | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 55
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:79370 Liu C, et al., Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory