Mc4r Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mc4r
melanocortin 4 receptor
MGI:99457

51 phenotypes from 19 alleles in 30 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Crh^{tm1.1(cre)Dolsn}/\Crh⁺ \Mc4r^tm1Lowl/\Mc4r^tm1Lowl involves: 129S4/SvJaeSor * C57BL/6	obese	J:216397
\Crh^{tm1.1(cre)Dolsn}/\Crh⁺ \Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Oxt^{tm1.1(cre)Dolsn}/\Oxt⁺ involves: 129S4/SvJaeSor * C57BL/6	obese	J:216397
\Mc4r^Glu3/\Mc4r⁺ C57BL/6J-Mc4r^Glu3	increased body weight	J:116205
\Mc4r^Glu3/\Mc4r⁺ involves: 129S6/SvEvTac	hyperglycemia	J:85113
\Mc4r^Glu3/\Mc4r⁺ involves: 129S6/SvEvTac	increased susceptibility to weight gain	J:85113
\Mc4r^Glu3/\Mc4r⁺ involves: C57BL/6J	hyperglycemia	J:85113
\Mc4r^Glu3/\Mc4r⁺ involves: C57BL/6J	increased susceptibility to weight gain	J:85113
\Mc4r^Glu3/\Mc4r^Glu3 C57BL/6J-Mc4r^Glu3	decreased body weight	J:116205
	increased body weight	J:116205
	increased percent body fat/body weight	J:116205
	obese	J:116205
\Mc4r^I194F/\Mc4r⁺ involves: C3HeB/FeJ * C57BL/6J	increased body weight	J:113730
\Mc4r^I194F/\Mc4r⁺ involves: C3HeB/FeJ * C57BL/6J	increased susceptibility to weight gain	J:113730
\Mc4r^I194F/\Mc4r^I194F involves: C3HeB/FeJ * C57BL/6J	increased body weight	J:113730
	increased susceptibility to weight gain	J:113730
	obese	J:113730
\Mc4r^m1Btlr/\Mc4r^m1Btlr C57BL/6J-Mc4r^m1Btlr	increased body weight	J:116205
\Mc4r^m1Btlr/\Mc4r^m1Btlr C57BL/6J-Mc4r^m1Btlr	obese	J:116205
\Mc4r^m2Btlr/\Mc4r^m2Btlr C57BL/6J-Mc4r^m2Btlr	increased body weight	J:218963
\Mc4r^m3Btlr/\Mc4r⁺ C57BL/6J-Mc4r^m3Btlr	increased body weight	J:225939
\Mc4r^m3Btlr/\Mc4r^m3Btlr C57BL/6J-Mc4r^m3Btlr	increased body weight	J:225939
\Mc4r^M4Btlr/\Mc4r⁺ C57BL/6J-Mc4r^M4Btlr	increased body weight	J:255207
\Mc4r^M4Btlr/\Mc4r^M4Btlr C57BL/6J-Mc4r^M4Btlr	increased body weight	J:255207
\Mc4r^M5Btlr/\Mc4r^M5Btlr C57BL/6J-Mc4r^M5Btlr	increased body weight	J:265170
\Mc4r^M6Btlr/\Mc4r^M6Btlr C57BL/6J-Mc4r^M6Btlr	increased body weight	J:274751
\Mc4r^m7Btlr/\Mc4r^m7Btlr C57BL/6J-Mc4r^m7Btlr	increased body weight	J:274968
\Mc4r^Mhdahwe13/\Mc4r⁺ C3HeB/FeJ-Mc4r^Mhdahwe13	increased body weight	J:82809
\Mc4r^Pkcp/\Mc4r⁺ C57BL/6J-Mc4r^Pkcp	increased body mass index	J:98867
\Mc4r^tm1.1Fbz/\Mc4r⁺ involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac	normal homeostasis/metabolism phenotype	J:225022
	increased abdominal fat pad weight	J:225022
	increased body length	J:225022
	increased body weight	J:225022
\Mc4r^tm1.1Fbz/\Mc4r^tm1.1Fbz involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac	decreased lean body mass	J:225022
	impaired glucose tolerance	J:225022
	increased abdominal fat pad weight	J:225022
	increased body length	J:225022
	increased body weight	J:225022
	increased energy expenditure	J:225022
	increased lean body mass	J:225022
	obese	J:225022
	polyphagia	J:225022
\Mc4r^tm1Dhu/\Mc4r^tm1Dhu B6.129S4-Mc4r^tm1Dhu	abnormal food intake	J:109494
\Mc4r^tm1Dhu/\Mc4r^tm1Dhu involves: 129S4/SvJae * C57BL/6J	abnormal circadian behavior phase	J:94617
	abnormal food intake	J:102986
	abnormal glucose homeostasis	J:38224
	abnormal locomotor activation	J:94617
	decreased osteoclast cell number	J:97566
	hyperglycemia	J:38224
	increased body size	J:38224
	increased body weight	J:38224, J:94617
	increased bone mass	J:97566
	increased circulating insulin level	J:38224
	increased circulating leptin level	J:38224
	increased susceptibility to diet-induced obesity	J:69814
	polyphagia	J:38224, J:94617
	reduced fertility	J:94617
\Mc4r^tm1Lex/\Mc4r^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	increased percent body fat/body weight	J:185494
\Mc4r^tm1Lowl/\Mc4r⁺ involves: 129S4/SvJae * C57BL/6	obese	J:199365
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl involves: 129S4/SvJae	obese	J:193452
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl involves: 129S4/SvJae * C57BL/6J	abnormal food intake	J:115192
	abnormal oxygen consumption	J:115192
	decreased circulating adiponectin level	J:177386
	decreased oxygen consumption	J:115192
	increased body length	J:115192
	increased circulating alanine transaminase level	J:177386
	increased circulating free fatty acids level	J:177386
	increased circulating insulin level	J:115192
	increased circulating interleukin-6 level	J:177386
	increased circulating leptin level	J:177386
	increased hepatocellular carcinoma incidence	J:177386
	increased liver triglyceride level	J:177386
	increased liver weight	J:177386
	increased susceptibility to diet-induced obesity	J:177386
	increased susceptibility to weight gain	J:177386
	increased total body fat amount	J:177386
	liver fibrosis	J:177386
	liver inflammation	J:177386
	microvesicular hepatic steatosis	J:177386
	obese	J:115192, J:177386
	polyphagia	J:115192
	white adipose tissue inflammation	J:177386
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Chat^tm1(cre)Lowl/\Chat⁺ involves: 129S4/SvJae * 129S6/SvEvTac	hypertension	J:193452
	increased circulating insulin level	J:193452
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Oxt^{tm1.1(cre)Dolsn}/\Oxt⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	obese	J:216397
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Pdyn^{tm1.1(cre)Mjkr}/\Pdyn⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	obese	J:216397
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Slc17a6^tm2(cre)Lowl/\Slc17a6⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	normal growth/size/body region phenotype	J:216397
	normal homeostasis/metabolism phenotype	J:216397
	normal respiratory system phenotype	J:216397
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Slc32a1^tm2(cre)Lowl/\Slc32a1⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	obese	J:216397
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Tg(Nes-cre)1Kln/0 involves: 129S4/SvJae * C57BL/6 * SJL	no abnormal phenotype detected	J:115192
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Tg(Sim1-cre)1Lowl/0 involves: 129S4/SvJae * C57BL/6J * FVB	abnormal food intake	J:115192
	abnormal oxygen consumption	J:115192
	normal behavior/neurological phenotype	J:115192
	decreased oxygen consumption	J:115192
	normal growth/size/body region phenotype	J:115192
	increased body weight	J:115192
	increased lean body mass	J:115192
	obese	J:115192
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Tg(Sim1-cre)2Lowl/0 involves: 129S4/SvJae * C57BL/6J * FVB	obese	J:115192
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Tg(Sim1-cre)#Lowl/? involves: 129S4/SvJae * FVB	normal cardiovascular system phenotype	J:193452
\Mc4r^tm1Lowl/\Mc4r^tm1Lowl \Tg(Zp3-cre)3Mrt/0 involves: 129S4/SvJae * C57BL/6J * FVB/N	no abnormal phenotype detected	J:115192
\Mc4r^tm1Matsu/\Mc4r^tm1Matsu C57BL/6J-Mc4r^tm1Matsu	hepatic steatosis	J:285412
	increased circulating alanine transaminase level	J:285412
	increased circulating aspartate transaminase level	J:285412
	increased circulating cholesterol level	J:285412
	increased circulating insulin level	J:285412
	increased food intake	J:285412
	increased hydroxyproline level	J:285412
	increased liver triglyceride level	J:285412
	increased liver weight	J:285412
	increased susceptibility to diet-induced obesity	J:285412
	liver fibrosis	J:285412
	liver inflammation	J:285412
\Mc4r^tm2.1Lowl/\Mc4r^tm2.1Lowl involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N	increased body length	J:193452, J:216397
	increased lean body mass	J:193452
	increased total body fat amount	J:216397
	obese	J:193452, J:216397
	polyphagia	J:216397
\Mc4r^tm2Lowl/\Mc4r^tm2Lowl involves: 129S4/SvJaeSor * 129S6/SvEvTac	increased body weight	J:216397
	increased total body fat amount	J:216397
	polyphagia	J:216397
\Mc4r^tm2Lowl/\Mc4r^tm2Lowl \Slc17a6^tm2(cre)Lowl/\Slc17a6⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	increased body length	J:216397
	increased total body fat amount	J:216397
	obese	J:216397
	polyphagia	J:216397
\Mc4r^tm2Lowl/\Mc4r^tm2Lowl \Tg(Sim1-cre)1Lowl/0 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	increased body length	J:216397
	increased total body fat amount	J:216397
	obese	J:216397
	polyphagia	J:216397
\Mc4r^Y302C/\Mc4r⁺ involves: C3HeB/FeJ * C57BL/6J	increased body weight	J:113730
\Mc4r^Y302C/\Mc4r⁺ involves: C3HeB/FeJ * C57BL/6J	increased susceptibility to weight gain	J:113730
\Mc4r^Y302C/\Mc4r^Y302C involves: C3HeB/FeJ * C57BL/6J	increased body weight	J:113730
	increased susceptibility to weight gain	J:113730
	obese	J:113730

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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