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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mc4r
melanocortin 4 receptor
MGI:99457
51 phenotypes from 19 alleles in 30 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Crhtm1.1(cre)Dolsn/Crh+
Mc4rtm1Lowl/Mc4rtm1Lowl
involves: 129S4/SvJaeSor * C57BL/6 		obese J:216397
Crhtm1.1(cre)Dolsn/Crh+
Mc4rtm1Lowl/Mc4rtm1Lowl
Oxttm1.1(cre)Dolsn/Oxt+
involves: 129S4/SvJaeSor * C57BL/6 		obese J:216397
Mc4rGlu3/Mc4r+
C57BL/6J-Mc4rGlu3 		increased body weight J:116205
Mc4rGlu3/Mc4r+
involves: 129S6/SvEvTac 		hyperglycemia J:85113
increased susceptibility to weight gain J:85113
Mc4rGlu3/Mc4r+
involves: C57BL/6J 		hyperglycemia J:85113
increased susceptibility to weight gain J:85113
Mc4rGlu3/Mc4rGlu3
C57BL/6J-Mc4rGlu3 		decreased body weight J:116205
increased body weight J:116205
increased percent body fat/body weight J:116205
obese J:116205
Mc4rI194F/Mc4r+
involves: C3HeB/FeJ * C57BL/6J 		increased body weight J:113730
increased susceptibility to weight gain J:113730
Mc4rI194F/Mc4rI194F
involves: C3HeB/FeJ * C57BL/6J 		increased body weight J:113730
increased susceptibility to weight gain J:113730
obese J:113730
Mc4rm1Btlr/Mc4rm1Btlr
C57BL/6J-Mc4rm1Btlr 		increased body weight J:116205
obese J:116205
Mc4rm2Btlr/Mc4rm2Btlr
C57BL/6J-Mc4rm2Btlr 		increased body weight J:218963
Mc4rm3Btlr/Mc4r+
C57BL/6J-Mc4rm3Btlr 		increased body weight J:225939
Mc4rm3Btlr/Mc4rm3Btlr
C57BL/6J-Mc4rm3Btlr 		increased body weight J:225939
Mc4rM4Btlr/Mc4r+
C57BL/6J-Mc4rM4Btlr 		increased body weight J:255207
Mc4rM4Btlr/Mc4rM4Btlr
C57BL/6J-Mc4rM4Btlr 		increased body weight J:255207
Mc4rM5Btlr/Mc4rM5Btlr
C57BL/6J-Mc4rM5Btlr 		increased body weight J:265170
Mc4rM6Btlr/Mc4rM6Btlr
C57BL/6J-Mc4rM6Btlr 		increased body weight J:274751
Mc4rm7Btlr/Mc4rm7Btlr
C57BL/6J-Mc4rm7Btlr 		increased body weight J:274968
Mc4rMhdahwe13/Mc4r+
C3HeB/FeJ-Mc4rMhdahwe13 		increased body weight J:82809
Mc4rPkcp/Mc4r+
C57BL/6J-Mc4rPkcp 		increased body mass index J:98867
Mc4rtm1.1Fbz/Mc4r+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac 		normal homeostasis/metabolism phenotype J:225022
increased abdominal fat pad weight J:225022
increased body length J:225022
increased body weight J:225022
Mc4rtm1.1Fbz/Mc4rtm1.1Fbz
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac 		decreased lean body mass J:225022
impaired glucose tolerance J:225022
increased abdominal fat pad weight J:225022
increased body length J:225022
increased body weight J:225022
increased energy expenditure J:225022
increased lean body mass J:225022
obese J:225022
polyphagia J:225022
Mc4rtm1Dhu/Mc4rtm1Dhu
B6.129S4-Mc4rtm1Dhu 		abnormal food intake J:109494
Mc4rtm1Dhu/Mc4rtm1Dhu
involves: 129S4/SvJae * C57BL/6J 		abnormal circadian behavior phase J:94617
abnormal food intake J:102986
abnormal glucose homeostasis J:38224
abnormal locomotor activation J:94617
decreased osteoclast cell number J:97566
hyperglycemia J:38224
increased body size J:38224
increased body weight J:38224, J:94617
increased bone mass J:97566
increased circulating insulin level J:38224
increased circulating leptin level J:38224
increased susceptibility to diet-induced obesity J:69814
polyphagia J:38224, J:94617
reduced fertility J:94617
Mc4rtm1Lex/Mc4rtm1Lex
involves: 129S5/SvEvBrd * C57BL/6J 		increased percent body fat/body weight J:185494
Mc4rtm1Lowl/Mc4r+
involves: 129S4/SvJae * C57BL/6 		obese J:199365
Mc4rtm1Lowl/Mc4rtm1Lowl
involves: 129S4/SvJae 		obese J:193452
Mc4rtm1Lowl/Mc4rtm1Lowl
involves: 129S4/SvJae * C57BL/6J 		abnormal food intake J:115192
abnormal oxygen consumption J:115192
decreased circulating adiponectin level J:177386
decreased oxygen consumption J:115192
increased body length J:115192
increased circulating alanine transaminase level J:177386
increased circulating free fatty acids level J:177386
increased circulating insulin level J:115192
increased circulating interleukin-6 level J:177386
increased circulating leptin level J:177386
increased hepatocellular carcinoma incidence J:177386
increased liver triglyceride level J:177386
increased liver weight J:177386
increased susceptibility to diet-induced obesity J:177386
increased susceptibility to weight gain J:177386
increased total body fat amount J:177386
liver fibrosis J:177386
liver inflammation J:177386
microvesicular hepatic steatosis J:177386
obese J:115192, J:177386
polyphagia J:115192
white adipose tissue inflammation J:177386
Mc4rtm1Lowl/Mc4rtm1Lowl
Chattm1(cre)Lowl/Chat+
involves: 129S4/SvJae * 129S6/SvEvTac 		hypertension J:193452
increased circulating insulin level J:193452
Mc4rtm1Lowl/Mc4rtm1Lowl
Oxttm1.1(cre)Dolsn/Oxt+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 		obese J:216397
Mc4rtm1Lowl/Mc4rtm1Lowl
Pdyntm1.1(cre)Mjkr/Pdyn+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 		obese J:216397
Mc4rtm1Lowl/Mc4rtm1Lowl
Slc17a6tm2(cre)Lowl/Slc17a6+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		normal growth/size/body region phenotype J:216397
normal homeostasis/metabolism phenotype J:216397
normal respiratory system phenotype J:216397
Mc4rtm1Lowl/Mc4rtm1Lowl
Slc32a1tm2(cre)Lowl/Slc32a1+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		obese J:216397
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Nes-cre)1Kln/0
involves: 129S4/SvJae * C57BL/6 * SJL 		no abnormal phenotype detected J:115192
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Sim1-cre)1Lowl/0
involves: 129S4/SvJae * C57BL/6J * FVB 		abnormal food intake J:115192
abnormal oxygen consumption J:115192
normal behavior/neurological phenotype J:115192
decreased oxygen consumption J:115192
normal growth/size/body region phenotype J:115192
increased body weight J:115192
increased lean body mass J:115192
obese J:115192
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Sim1-cre)2Lowl/0
involves: 129S4/SvJae * C57BL/6J * FVB 		obese J:115192
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Sim1-cre)#Lowl/?
involves: 129S4/SvJae * FVB 		normal cardiovascular system phenotype J:193452
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Zp3-cre)3Mrt/0
involves: 129S4/SvJae * C57BL/6J * FVB/N 		no abnormal phenotype detected J:115192
Mc4rtm1Matsu/Mc4rtm1Matsu
C57BL/6J-Mc4rtm1Matsu 		hepatic steatosis J:285412
increased circulating alanine transaminase level J:285412
increased circulating aspartate transaminase level J:285412
increased circulating cholesterol level J:285412
increased circulating insulin level J:285412
increased food intake J:285412
increased hydroxyproline level J:285412
increased liver triglyceride level J:285412
increased liver weight J:285412
increased susceptibility to diet-induced obesity J:285412
liver fibrosis J:285412
liver inflammation J:285412
Mc4rtm2.1Lowl/Mc4rtm2.1Lowl
involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N 		increased body length J:193452, J:216397
increased lean body mass J:193452
increased total body fat amount J:216397
obese J:193452, J:216397
polyphagia J:216397
Mc4rtm2Lowl/Mc4rtm2Lowl
involves: 129S4/SvJaeSor * 129S6/SvEvTac 		increased body weight J:216397
increased total body fat amount J:216397
polyphagia J:216397
Mc4rtm2Lowl/Mc4rtm2Lowl
Slc17a6tm2(cre)Lowl/Slc17a6+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		increased body length J:216397
increased total body fat amount J:216397
obese J:216397
polyphagia J:216397
Mc4rtm2Lowl/Mc4rtm2Lowl
Tg(Sim1-cre)1Lowl/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		increased body length J:216397
increased total body fat amount J:216397
obese J:216397
polyphagia J:216397
Mc4rY302C/Mc4r+
involves: C3HeB/FeJ * C57BL/6J 		increased body weight J:113730
increased susceptibility to weight gain J:113730
Mc4rY302C/Mc4rY302C
involves: C3HeB/FeJ * C57BL/6J 		increased body weight J:113730
increased susceptibility to weight gain J:113730
obese J:113730
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04/16/2024
MGI 6.23 		The Jackson Laboratory