Mc4r^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mc4r^m1Btlr
• Name: melanocortin 4 receptor; mutation 1, Bruce Beutler
• MGI ID: MGI:3723065
• Synonyms: SB, Southbeach
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^m1Btlr page

Mc4r^m1Btlr/Mc4r^m1Btlr are obese

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The molecular lesion was identified as a T-to-C transition mutation in codon 300, which results in a leucine to proline change in the encoded protein. (J:116205)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 44 strains or lines available

References

• Original: J:116205 Meehan TP, et al., Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mamm Genome. 2006 Dec;17(12):1162-71
• All: 1 reference(s)