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Targeted Allele Detail
Symbol: Mc4rtm1Lowl
Name: melanocortin 4 receptor; targeted mutation 1, Bradford B Lowell
MGI ID: MGI:3512050
Synonyms: loxTB Mc4r, Mc4rtb
Gene: Mc4r  Location: Chr18:66990776-66993558 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Alliance: Mc4rtm1Lowl page
Germline Transmission:  Earliest citation of germline transmission: J:115192
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
Mutation detailsA loxP flanked PGK-neomycin selection marker inserted in the 5' UTR created a null allele. Cre recombinase deletes the selection marker, restoring normal activity of the allele. Mice fail to respond to MC4R agonist MTII. This is a null allele that can be "reactivated" by cre recombinase. (J:115192)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:  37 strains or lines available
Original:  J:115192 Balthasar N, et al., Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005 Nov 4;123(3):493-505
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory