About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nodal
nodal growth differentiation factor
MGI:97359
75 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
\Acvr1btm1Enl/\Acvr1b+
\Gdf1tm1Sjl/\Gdf1+
\Nodaltm1Rob/\Nodal+
involves: 129/Sv * C57BL/6 		abnormal forebrain morphology J:108723
abnormal nasal septum morphology J:108723
\Acvr1ctm1Cfi/\Acvr1c+
\Gdf1tm1Sjl/\Gdf1+
\Nodaltm1Rob/\Nodal+
involves: 129 * C57BL/6 		no abnormal phenotype detected J:108723
\Acvr1ctm1Cfi/\Acvr1ctm1Cfi
\Nodaltm1Rob/\Nodal+
involves: 129P2/OlaHsd * 129/Sv 		normal mortality/aging J:94135
\Acvr2atm1Hsch/\Acvr2atm1Hsch
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S1/Sv * C57BL/6J 		abnormal gastrulation J:57262
abnormal head morphology J:57262
cyclopia J:57262
decreased forebrain size J:57262
embryonic lethality, complete penetrance J:57262
\Cer1tm1Bhr/\Cer1tm1Bhr
\Lefty1tm1Hmd/\Lefty1tm1Hmd
\Nodaltm1Rob/\Nodal+
involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1 		abnormal developmental patterning J:81339
abnormal embryo development J:81339
abnormal embryonic tissue morphology J:81339
abnormal embryonic-extraembryonic boundary morphology J:81339
\Cer1tm1Bhr/\Cer1tm1Bhr
\Lefty1tm1Sla/\Lefty1tm1Sla
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S7/SvEvBrd * CD-1 		abnormal developmental patterning J:81339
abnormal embryo development J:81339
abnormal embryonic tissue morphology J:81339
abnormal embryonic-extraembryonic boundary morphology J:81339
\Chrdtm1Emdr/\Chrdtm1Emdr
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal anterior definitive endoderm morphology J:161524
abnormal direction of heart looping J:161524
abnormal embryonic tissue morphology J:161524
abnormal mesendoderm development J:161524
abnormal prechordal plate morphology J:161524
fused first pharyngeal arch J:161524
holoprosencephaly J:161524
\Col2a1tm1.1Ksec/\Col2a1+
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal head morphology J:163739
\Col2a1tm1.1Ksec/\Col2a1tm1.1Ksec
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal head morphology J:163739
\Dand5tm1Belo/\Dand5tm1Belo
\Nodaltm1.1Mku/\Nodal+
involves: 129/Ola * C57BL/6J 		abnormal direction of heart looping J:93051
\Drap1tm1Mms/\Drap1tm1Mms
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S6/SvEvTac 		abnormal gastrulation J:80667
abnormal primitive streak formation J:80667
embryonic lethality, complete penetrance J:80667
\Eomestm1.1Rob/\Eomes+
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal amniotic cavity morphology J:131055
abnormal anterior visceral endoderm cell migration J:131055
abnormal developmental patterning J:131055
abnormal germ layer development J:131055
abnormal left-right axis patterning J:131055
abnormal notochord morphology J:131055
abnormal primitive node morphology J:131055
abnormal rostral-caudal patterning of the somites J:131055
disorganized embryonic tissue J:131055
embryonic-extraembryonic boundary constriction J:131055
enlarged floor plate J:131055
failure of primitive streak formation J:131055
increased somite number J:131055
rostral body truncation J:131055
rostral-caudal axis duplication J:131055
\Eomestm1.1Rob/\Eomes+
\Nodaltm4Rob/\Nodaltm4Rob
involves: 129S/SvEv * C57BL/6 * CBA 		no abnormal phenotype detected J:131055
\Eomestm1Rob/\Eomes+
\Nodaltm1Rob/\Nodal+
\Edil3Tg(Sox2-cre)1Amc/\Edil3+
involves: 129S/SvEv * C57BL/6 * CBA 		prenatal lethality J:131055
rostral body truncation J:131055
\Foxa2tm1Jrt/\Foxa2+
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal direction of embryo turning J:32935
delayed embryo turning J:32935
situs ambiguus J:32935
\Gdf1tm1Sjl/\Gdf1tm1Sjl
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal diencephalon morphology J:108723
abnormal first pharyngeal arch morphology J:108723
abnormal foregut morphology J:108723
abnormal mesendoderm development J:108723
abnormal neural fold formation J:108723
abnormal neural plate morphology J:108723
abnormal third ventricle morphology J:108723
absent mandible J:108723
absent notochord J:108723
absent prechordal plate J:108723
absent tongue J:108723
cleft upper lip J:108723
embryonic lethality during organogenesis, incomplete penetrance J:108723
fused first pharyngeal arch J:108723
holoprosencephaly J:108723
nasal septum hypoplasia J:108723
truncated notochord J:108723
\Lefty2tm1Hmd/\Lefty2tm1Hmd
\Nodaltm1Rob/\Nodal+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6Cr 		abnormal embryo development J:57907
embryonic lethality between implantation and somite formation, complete penetrance J:57907
\Nodaltm1.1Dbc/\Nodaltm1.1Dbc
involves: 129S/SvEv * C57BL/6 		abnormal mesendoderm development J:112799
abnormal primitive streak formation J:112799
embryonic growth arrest J:112799
embryonic lethality between implantation and somite formation, complete penetrance J:112799
\Nodaltm1Hmd/\Nodal+
\Tg(Rr443-Lefty1,-lacZ)36Hmd/0
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ) 		abnormal cardiac outflow tract development J:82703
abnormal digestive system development J:82703
abnormal left-right axis patterning J:82703
abnormal liver morphology J:82703
dextrocardia J:82703
right atrial isomerism J:82703
right pulmonary isomerism J:82703
right-sided isomerism J:82703
small spleen J:82703
\Nodaltm1Rob/\Nodal+
\Nogtm1Amc/\Nogtm1Amc
involves: 129S/SvEv * 129S1/Sv 		normal embryo phenotype J:161524
\Nodaltm1Rob/\Nodal+
\Zic2Ku/\Zic2Ku
129S.Cg-Nodaltm1Rob Zic2Ku 		rostral body truncation J:238567
\Nodaltm1Rob/\Nodal+
\Edil3Tg(Sox2-cre)1Amc/\Edil3+
\Tgif1tm1Caw/\Tgif1tm1Caw
\Tgif2tm1Dwot/\Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		abnormal embryonic neuroepithelium morphology J:183402
abnormal forebrain development J:183402
abnormal left-right axis patterning J:157256
normal cardiovascular system phenotype J:157256
decreased forebrain size J:183402
embryonic growth retardation J:183402
holoprosencephaly J:183402
rostral body truncation J:183402
\Nodaltm1Rob/\Nodal+
\Tgif1tm1Dwot/\Tgif1tm1Dwot
\Tgif2tm1Dwot/\Tgif2tm1Dwot
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		normal embryo phenotype J:157256
\Nodaltm1Rob/\Nodal+
\Smad2tm1.1Epb/\Smad2+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J * SJL 		abnormal eye development J:183402
abnormal olfactory epithelium morphology J:183402
embryonic growth retardation J:183402
holoprosencephaly J:183402
proboscis J:183402
\Nodaltm1Rob/\Nodal+
\Trim33tm1.2Los/\Trim33tm1.2Los
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		normal embryo phenotype J:163858
expanded anterior visceral endoderm J:163858
\Nodaltm1Rob/\Nodaltm2Rob
\Trim33tm1.2Los/\Trim33tm1.2Los
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		normal embryo phenotype J:163858
\Nodaltm2Rob/\Nodal+
\Zic2Ku/\Zic2Ku
129S.Cg-Nodaltm2Rob Zic2Ku 		abnormal mesendoderm development J:238567
rostral body truncation J:238567
\Nodaltm2Rob/\Nodaltm2Rob
\Zic2Ku/\Zic2+
129S.Cg-Nodaltm2Rob Zic2Ku 		rostral body truncation J:238567
\Nodaltm2Rob/\Nodaltm2Rob
\Zic2Ku/\Zic2Ku
129S.Cg-Nodaltm2Rob Zic2Ku 		rostral body truncation J:238567
\Smad2tm1Enl/\Smad2+
\Nodaltm1Rob/\Nodal+
involves: 129S/SvEv * 129S4/SvJae 		abnormal craniofacial morphology J:48467
abnormal direction of embryo turning J:48467
abnormal gastrulation J:48467
abnormal heart looping J:48467
abnormal lateral plate mesoderm morphology J:48467
abnormal left-right axis patterning J:48467
cyclopia J:48467
right pulmonary isomerism J:48467
rostral body truncation J:48467
transposition of great arteries J:48467
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory