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Nodal Gene Detail
Summary
  • Symbol
    Nodal
  • Name
    nodal growth differentiation factor
  • Synonyms
    Tg.413d
Location &
Maps
more
  • Sequence Map
    Chr10:61253751-61261117 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97359
 protein coding gene Chr10:61253751-61261117 (+)
129S1/SvImJ ENSMUSG00200025426
 protein coding gene Chr10:57919979-57927336 (+)
A/J ENSMUSG00195025646
 protein coding gene Chr10:58232534-58239905 (+)
AKR/J ENSMUSG00220040449
 protein coding gene Chr10:57924682-57932047 (+)
BALB/cJ ENSMUSG00180022100
 protein coding gene Chr10:58274776-58282147 (+)
C3H/HeJ ENSMUSG00175022751
 protein coding gene Chr10:58127208-58134564 (+)
C57BL/6NJ ENSMUSG00215014884
 protein coding gene Chr10:57872921-57880295 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015366
 protein coding gene Chr10:55918813-55925684 (+)
CAST/EiJ ENSTCUG00005026561
 protein coding gene Chr10:57922360-57929634 (+)
CBA/J ENSMUSG00210031271
 protein coding gene Chr10:58005505-58012871 (+)
DBA/2J ENSMUSG00185040933
 protein coding gene Chr10:58352305-58359669 (+)
FVB/NJ ENSMUSG00205019159
 protein coding gene Chr10:58025886-58033259 (+)
JF1/MsJ ENSUMUG00000021242
 protein coding gene Chr10:59585527-59592801 (+)
LP/J ENSMUSG00230019901
 protein coding gene Chr10:60155400-60162767 (+)
NOD/ShiLtJ ENSMUSG00190033089
 protein coding gene Chr10:58338058-58345421 (+)
NZO/HlLtJ ENSMUSG00225044584
 protein coding gene Chr10:64436348-64443714 (+)
PWK/PhJ ENSLUMG00010021451
 protein coding gene Chr10:57948071-57955322 (+)
SPRET/EiJ ENSMSPG00010025601
 protein coding gene Chr10:59543724-59550942 (+)
WSB/EiJ ENSIUOG00005038512
 protein coding gene Chr10:57909357-57916785 (+)



Homology
more
  • Human Ortholog
    NODAL, nodal growth differentiation factor
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NODAL, nodal growth differentiation factor
  • Synonyms
    HTX5
  • Links
    NCBI Gene ID: 4838
    UniProt: Q96S42

  • Chr Location
    10q22.1; chr10:70431936-70447951 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NODAL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    111 phenotypes from 15 alleles in 18 genetic backgrounds
    75 phenotypes from multigenic genotypes
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants fail to form a primitive streak, show placental defects and die at gastrulation. Hypomorphic mutants are defective in anterior-posterior, anterior-midline, and left-right body patterning, resulting in multiple organ defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    128
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1472
  • Tissues
    109
  • cDNA Data
    9
  • Literature Summary
    268
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18119 NCBI Gene Model | MGI Sequence Detail 7367 C57BL/6J ±  kb
    transcript NM_013611 RefSeq | MGI Sequence Detail 2095 C57BL/6  
    polypeptide P43021 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 3
      cDNA 16
      Primer pair 21
      Other 52
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12907, MGD-MRK-15051, MGI:98714
    References
    more
    • Summaries
      All 423
      Developmental Gene Expression 268
      Diseases 1
      Gene Ontology 36
      Phenotypes 119
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:383100 Abraham E, et al., YAP1 and QSER1 are key modulators of embryonic signaling pathways in the mammalian epiblast. EMBO Rep. 2026 Mar 26;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory