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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nodal
nodal growth differentiation factor
MGI:97359
112 phenotypes from 15 alleles in 18 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Meox2tm1(cre)Sor/Meox2+
Nodaltm1Rob/Nodaltm5Rob
involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
abnormal developmental patterning J:93140
abnormal proximal-distal axis patterning J:93140
abnormal visceral yolk sac morphology J:93140
rostral body truncation J:93140
NodalTgR(MPSVNeo)413.dRob/NodalTgR(MPSVNeo)413.dRob
129S/SvEv-NodalTgR(MPSVNeo)413.dRob
abnormal developmental patterning J:11389
abnormal ectoderm development J:19211
abnormal embryonic tissue morphology J:11389, J:19211
abnormal extraembryonic ectoderm morphology J:19211
abnormal extraembryonic mesoderm development J:19211
abnormal extraembryonic tissue morphology J:19211
abnormal mesoderm development J:3969
abnormal parietal yolk sac morphology J:11389
abnormal spongiotrophoblast layer morphology J:70738
absent allantois J:11389
absent amnion J:11389
absent amniotic folds J:19211
absent head fold J:11389
absent placental labyrinth J:70738
absent somites J:11389
absent visceral yolk sac J:11389
decreased embryo size J:11389
embryonic growth arrest J:19211
failure of primitive streak formation J:19211
increased trophoblast giant cell number J:70738
prenatal lethality, complete penetrance J:11389
small ectoplacental cone J:11389
NodalTgR(MPSVNeo)413.dRob/Nodaltm1Mku
involves: 129S1/Sv
increased spongiotrophoblast size J:70738
increased trophoblast giant cell number J:70738
thin placenta labyrinth J:70738
NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
involves: 129S/SvEv * C57BL/6
abnormal embryonic neuroepithelium morphology J:84300
abnormal foregut morphology J:84300
abnormal heart looping J:84300
absent forebrain J:84300
absent midbrain J:84300
decreased embryonic neuroepithelial cell proliferation J:84300
embryonic lethality between somite formation and embryo turning, complete penetrance J:84300
enlarged pericardium J:84300
pericardial edema J:84300
rostral body truncation J:84300
NodalTgR(MPSVNeo)413.dRob/Nodaltm6Rob
involves: 129S/SvEv * C57BL/6
abnormal direction of heart looping J:94418
abnormal interventricular septum morphology J:94418
common atrium J:94418
delayed heart development J:94418
right pulmonary isomerism J:94418
thin myocardium compact layer J:94418
trabecula carnea hypoplasia J:94418
Nodaltm1.1Hmd/Nodaltm1.1Hmd
involves: 129S1/Sv * 129X1/SvJ
no abnormal phenotype detected J:97079
Nodaltm1.1Mku/Nodaltm2Mku
involves: 129S1/Sv
no abnormal phenotype detected J:142430
Nodaltm1.1Mku/Nodaltm2Mku
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * C3H * C57BL/6
abnormal direction of heart looping J:142430
abnormal interventricular septum morphology J:142430
abnormal left-right axis patterning J:142430
absent spleen J:142430
normal embryo phenotype J:142430
right pulmonary isomerism J:142430
small spleen J:142430
transposition of great arteries J:142430
Nodaltm1.1Ysa/Nodaltm1.1Ysa
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: C57BL/6 * C57BL/6NTac
abnormal male germ cell morphology J:191052
Nodaltm1.2Rob/Nodaltm3Rob
involves: 129S/SvEv * MF1
abnormal direction of heart looping J:79098
abnormal heart development J:79098
atrial septal defect J:79098
common atrium J:79098
heterotaxia J:79098
neonatal lethality, complete penetrance J:79098
right pulmonary isomerism J:79098
situs ambiguus J:79098
small spleen J:79098
transposition of great arteries J:79098
Nodaltm1b(EUCOMM)Wtsi/Nodal+
C57BL/6N-Nodaltm1b(EUCOMM)Wtsi/H
corneal vascularization J:211773
decreased locomotor activity J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
increased circulating triglyceride level J:211773
increased grip strength J:211773
increased large unstained cell number J:211773
Nodaltm1b(EUCOMM)Wtsi/Nodaltm1b(EUCOMM)Wtsi
C57BL/6N-Nodaltm1b(EUCOMM)Wtsi/H
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Nodaltm1Hmd/Nodaltm1Hmd
either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)
abnormal digestive system development J:82703
abnormal heart position or orientation J:82703
abnormal left-right axis patterning J:82703
abnormal liver morphology J:82703
abnormal spleen morphology J:82703
abnormal stomach position or orientation J:82703
embryonic growth arrest J:82703
embryonic lethality during organogenesis, incomplete penetrance J:82703
perinatal lethality, complete penetrance J:82703
right atrial isomerism J:82703
right pulmonary isomerism J:82703
right-sided isomerism J:82703
spleen hypoplasia J:82703
transposition of great arteries J:82703
Nodaltm1Mku/Nodaltm1.1Mku
either: (involves: 129S1/Sv * FVB/N) or (involves: 129S1/Sv * C57BL/6J * FVB/N)
abnormal anterior visceral endoderm morphology J:73506
abnormal brain development J:73506
abnormal developmental patterning J:73506
abnormal digestive system development J:73506
abnormal direction of heart looping J:73506
abnormal embryo turning J:73506
abnormal embryonic neuroepithelium morphology J:73506
abnormal embryonic tissue morphology J:73506
abnormal gastrulation J:73506
abnormal head development J:73506
abnormal hindgut morphology J:73506
abnormal lateral plate mesoderm morphology J:73506
abnormal neural fold formation J:73506
abnormal prechordal plate morphology J:73506
abnormal primitive node morphology J:73506
abnormal primitive streak morphology J:73506
abnormal rostral-caudal axis patterning J:73506
abnormal stomach position or orientation J:73506
absent floor plate J:73506
absent foregut J:73506
absent heart tube J:73506
absent notochord J:73506
absent prechordal plate J:73506
absent primitive node J:73506
embryonic growth arrest J:73506
embryonic lethality, incomplete penetrance J:73506
embryonic-extraembryonic boundary constriction J:73506
fused somites J:73506
holoprosencephaly J:73506
pale liver J:73506
perinatal lethality, complete penetrance J:73506
right pulmonary isomerism J:73506
small liver J:73506
transposition of great arteries J:73506
truncated foregut J:73506
truncated notochord J:73506
Nodaltm1Mku/Nodaltm1Mku
involves: 129S1/Sv
no abnormal phenotype detected J:73506
Nodaltm1Mku/Nodaltm1Mku
Mesp1tm2(cre)Ysa/Mesp1+
Tg(Pitx2-lacZ)1Mbf/0
involves: 129S1/Sv * C57BL/6 * CBA
abnormal heart looping J:167616
Nodaltm1Rob/Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
no abnormal phenotype detected J:32935
Nodaltm1Rob/Nodaltm1Rob
involves: 129S/SvEv
abnormal developmental patterning J:32935
abnormal embryonic tissue morphology J:32935
abnormal extraembryonic tissue morphology J:32935
decreased embryo size J:32935
embryonic growth arrest J:32935
prenatal lethality, complete penetrance J:32935
Nodaltm1Rob/Nodaltm2Rob
involves: 129S/SvEv * ICR
abnormal gastrulation J:77125
abnormal gastrulation movements J:77125
abnormal heart looping J:77125
abnormal primitive node morphology J:77125
abnormal rostral-caudal axis patterning J:77125
abnormal visceral endoderm morphology J:77125
absent notochord J:77125
embryonic-extraembryonic boundary constriction J:77125
fused somites J:77125
Nodaltm1Rob/Nodaltm5Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6
abnormal developmental patterning J:93140
abnormal distal visceral endoderm morphology J:93140
abnormal germ layer development J:93140
absent mesoderm J:93140
Nodaltm2Rob/Nodaltm2Rob
129S(Cg)-Nodaltm2Rob
abnormal mesendoderm development J:238567
rostral body truncation J:238567
Nodaltm2Rob/Nodaltm2Rob
involves: 129S/SvEv * ICR
abnormal heart apex morphology J:77125
abnormal heart looping J:77125
abnormal heart position or orientation J:77125
aortic hypertrophy J:77125
decreased body size J:77125
normal embryo phenotype J:77125
premature death J:77125
prenatal lethality, incomplete penetrance J:77125
right pulmonary isomerism J:77125
right-sided isomerism J:77125
Nodaltm3Rob/Nodaltm3Rob
Not Specified
no abnormal phenotype detected J:79098
Nodaltm4Rob/Nodaltm4Rob
involves: 129/Sv * 129S/SvEv * C57BL/6
abnormal craniofacial development J:84300
abnormal heart development J:84300
perinatal lethality, complete penetrance J:84300
prenatal lethality, incomplete penetrance J:84300
Nodaltm6Rob/Nodaltm6Rob
involves: 129S/SvEv * C57BL/6
no abnormal phenotype detected J:94418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory