Nodal^{TgR(MPSVNeo)413.dRob}
Transgenic Allele Detail

Summary

• Symbol: Nodal^{TgR(MPSVNeo)413.dRob}
• Name: nodal growth differentiation factor; retroviral transgene insertion, Elizabeth J Robertson
• MGI ID: MGI:1856970
• Synonyms: 413.d, nodal, Nodal^Tg413.d
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^{TgR(MPSVNeo)413.dRob} page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:11389
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Transgene description

• Transgene Type: Transgenic (Null/knockout)
• Mutation: Viral insertion
• Mutation details: A chimeric animal derived from ES cells that were infected with a MPSVmos^-1 Neo retroviral vector was shown to have a insertional mutation event in the first intron of the gene. Northern blot analysis on homozygous cell lines confirmed that the mutation interfered with the normal transcription of this gene. (J:19211, J:161059)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 41 strains or lines available

References

• Original: J:11389 Conlon FL, et al., A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development. 1991 Apr;111(4):969-81
• All: 12 reference(s)