Nodal^tm6Rob
Targeted Allele Detail

Summary

• Symbol: Nodal^tm6Rob
• Name: nodal growth differentiation factor; targeted mutation 6, Elizabeth J Robertson
• MGI ID: MGI:3521719
• Synonyms: Nodal^deltaaie
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm6Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94418
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The 470 bp minimal AIE regulatory element was deleted upon replacement with a floxed PGK-hygro and its subsequent Cre-mediated excision. (J:94418)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 41 strains or lines available

References

• Original: J:94418 Vincent SD, et al., Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements. Mech Dev. 2004 Nov;121(11):1403-15
• All: 1 reference(s)