Smad2^tm1Enl
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1Enl
• Name: SMAD family member 2; targeted mutation 1, En Li
• MGI ID: MGI:1857692
• Synonyms: Smad2^mh1
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1Enl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48467
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced part of exon 3 and all of exon 4, encoding amino acids 100 - 174, part of the conserved MH1 domain. (J:48467)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 50 strains or lines available

References

• Original: J:48467 Nomura M, et al., Smad2 role in mesoderm formation, left-right patterning and craniofacial development [see comments]. Nature. 1998 Jun 25;393(6687):786-90
• All: 5 reference(s)