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Targeted Allele Detail
Symbol: Acvr2atm1Hsch
Name: activin receptor IIA; targeted mutation 1,Heinrich Schrewe
MGI ID: MGI:2179547
Synonyms: AcrRIIA-, Acvr2atm1Enl, IIA-, IIA-KO
Gene: Acvr2a  Location: Chr2:48704121-48793276 bp, + strand  Genetic Position: Chr2, 28.38 cM
Alliance: Acvr2atm1Hsch page
Germline Transmission:  Earliest citation of germline transmission: J:57262
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe kinase domain of this gene was disrupted by replacing 135 bp of exon 9 and 1.3 kb of intron 9 with a neo cassette by homologous recombination. Homozygous mutant animals were identified by Southern blot analysis. (J:57262)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 25 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvr2a Mutation:  29 strains or lines available
Original:  J:57262 Song J, et al., The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol. 1999 Sep 1;213(1):157-69
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory